Ruprecht-Karls-Universität Heidelberg
Willkommen am COS Heidelberg

Das Centre for Organismal Studies (COS) Heidelberg hat sich die Erforschung der organismischen Biologie über die Grenzen der biologischen Organisationsstufen hinweg zum Ziel gesetzt. Forschung und Lehre des COS widmen sich der Biologie der Organismen von den molekularen Grundlagen über die Zellbiologie, Entwicklungsbiologie und Physiologie bis hin zu Evolution und Biodiversität sowie Systembiologie und Biotechnologie in pflanzlichen und tierischen Systemen.


HMLS Preis für Thomas Holstein

Der 2015 HMLS Investigator Award wird am 9. Dezember 2015 an Thomas Holstein verliehen. Damit werden seine herausragenden Verdienste um die Heidelberger Lebenswissenschaften gewürdigt.


Ehrendoktorwürde für Melitta Schachner

Die Universität Heidelberg verleiht der Neurobiologin Melitta Schachner Camartin am 30. November 2015 die Ehrendoktorwürde der Naturwissenschaftlich-Mathematischen Gesamt-fakultät.

Nächste Veranstaltung:

COS Seminar

Extrinsic influences directing fate specification during development and regeneration

Patricia Jusuf, Australian Regenerative Medicine Institute, Monash University (Australia)

07.12.2015 10:00

INF 230, kHS

Neueste Veröffentlichungen:
Baumgarten, S.; Simakov, O.; Esherick, L.Y.; Liew, Y.J.; Lehnert, E.M.; Michell, C.T.; Li, Y.; Hambleton, E.A.; Guse, A.; Oates, M.E.; Gough, J.; Weis, V.M.; Aranda, M.; Pringle, J.R.; Voolstra, C.R. 2015 The genome of Aiptasia, a sea anemone model for coral symbiosis Proc Natl Acad Sci U S A doi: 10.1073/pnas.1513318112 [Link]
Beckmann, A.; Xiao, S.; Muller, J.P.; Mercadante, D.; Nuchter, T.; Kroger, N.; Langhojer, F.; Petrich, W.; Holstein, T.W.; Benoit, M.; Grater, F.; Ozbek, S. 2015 A fast recoiling silk-like elastomer facilitates nanosecond nematocyst discharge BMC Biol 13 3 doi: 10.1186/s12915-014-0113-1 [Link]
Caroti, F.; Urbansky, S.; Wosch, M.; Lemke, S. 2015 Germ line transformation and in vivo labeling of nuclei in Diptera: report on Megaselia abdita (Phoridae) and Chironomus riparius (Chironomidae) Dev Genes Evol 225 3 179-186 doi: 10.1007/s00427-015-0504-5 [Link]
Chmielewski, A.K.; Kyrsting, A.; Mahou, P.; Wayland, M.T.; Muresan, L.; Evers, J.F.; Kaminski, C.F. 2015 Fast imaging of live organisms with sculpted light sheets Sci Rep 5 9385 doi: 10.1038/srep09385 [Link]
Couton, L.; Mauss, A.S.; Yunusov, T.; Diegelmann, S.; Evers, J.F.; Landgraf, M. 2015 Development of connectivity in a motoneuronal network in Drosophila larvae Curr Biol 25 5 568-576 doi: 10.1016/j.cub.2014.12.056 [Link]
Dinh, T.V.; Bienvenut, W.V.; Linster, E.; Feldman-Salit, A.; Jung, V.A.; Meinnel, T.; Hell, R.; Giglione, C.; Wirtz, M. 2015 Molecular identification and functional characterization of the first Nalpha-acetyltransferase in plastids by global acetylome profiling Proteomics 15 14 2426-2435 doi: 10.1002/pmic.201500025 [Link]
Grawunder, D.; Hambleton, E.A.; Bucher, M.; Wolfowicz, I.; Bechtoldt, N.; Guse, A. 2015 Induction of Gametogenesis in the Cnidarian Endosymbiosis Model Aiptasia sp Sci Rep 5 15677 doi: 10.1038/srep15677 [Link]
Heermann, S.; Schutz, L.; Lemke, S.; Krieglstein, K.; Wittbrodt, J. 2015 Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein Elife 4 doi: 10.7554/eLife.05216 [Link]
Jouannet, V.; Brackmann, K.; Greb, T. 2015 (Pro)cambium formation and proliferation: two sides of the same coin? Curr Opin Plant Biol 23 54-60 doi: 10.1016/j.pbi.2014.10.010 [Link]
Keinath, N.F.; Waadt, R.; Brugman, R.; Schroeder, J.I.; Grossmann, G.; Schumacher, K.; Krebs, M. 2015 Live Cell Imaging with R-GECO1 Sheds Light on flg22- and Chitin-Induced Transient [Ca] Patterns in Arabidopsis Mol Plant doi: 10.1016/j.molp.2015.05.006 [Link]
Koch, M.A. 2015 A new chromosome was born: comparative chromosome painting in Boechera Trends Plant Sci doi: 10.1016/j.tplants.2015.07.001 [Link]
Kondraskov, P.; Schutz, N.; Schussler, C.; de Sequeira, M.M.; Guerra, A.S.; Caujape-Castells, J.; Jaen-Molina, R.; Marrero-Rodriguez, A.; Koch, M.A.; Linder, P.; Kovar-Eder, J.; Thiv, M. 2015 Biogeography of Mediterranean Hotspot Biodiversity: Re-Evaluating the 'Tertiary Relict' Hypothesis of Macaronesian Laurel Forests PLoS One 10 7 e0132091 doi: 10.1371/journal.pone.0132091 [Link]
Li, D.; Baldwin, I.T.; Gaquerel, E. 2015 Navigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis Proc Natl Acad Sci U S A 112 30 E4147-55 doi: 10.1073/pnas.1503106112 [Link]
Linster, E.; Stephan, I.; Bienvenut, W.V.; Maple-Grodem, J.; Myklebust, L.M.; Huber, M.; Reichelt, M.; Sticht, C.; Geir Moller, S.; Meinnel, T.; Arnesen, T.; Giglione, C.; Hell, R.; Wirtz, M. 2015 Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis Nat Commun 6 7640 doi: 10.1038/ncomms8640 [Link]
Martinez de Alba, A.E.; Moreno, A.B.; Gabriel, M.; Mallory, A.C.; Christ, A.; Bounon, R.; Balzergue, S.; Aubourg, S.; Gautheret, D.; Crespi, M.D.; Vaucheret, H.; Maizel, A. 2015 In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs Nucleic Acids Research 1-12 doi: 10.1093/nar/gkv119 [Link]
Mau, M.; Lovell, J.T.; Corral, J.M.; Kiefer, C.; Koch, M.A.; Aliyu, O.M.; Sharbel, T.F. 2015 Hybrid apomicts trapped in the ecological niches of their sexual ancestors Proc Natl Acad Sci U S A 112 18 E2357-65 doi: 10.1073/pnas.1423447112 [Link]
Muir, G.; Ruiz-Duarte, P.; Hohmann, N.; Mable, B.K.; Novikova, P.; Schmickl, R.; Guggisberg, A.; Koch, M.A. 2015 Exogenous selection rather than cytonuclear incompatibilities shapes asymmetrical fitness of reciprocal Arabidopsis hybrids Ecol Evol 5 8 1734-1745 doi: 10.1002/ece3.1474 [Link]
Reinhardt, R.; Centanin, L.; Tavhelidse, T.; Inoue, D.; Wittbrodt, B.; Concordet, J.-P.; Martinez-Morales, J.R.; Wittbrodt, J. 2015 Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo Embo J 34 11 1572-1588 doi: 10.15252/embj.201490706 [Link]
Robinson, D.G. 2015 Endocytosis: Is there really a Recycling from Late Endosomes? Mol Plant doi: 10.1016/j.molp.2015.07.005 [Link]
Robinson, D.G.; Brandizzi, F.; Hawes, C.; Nakano, A. 2015 Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes? Plant Physiol 168 2 393-406 doi: 10.1104/pp.15.00124 [Link]
Stemmer, M.; Schuhmacher, L.-N.; Foulkes, N.S.; Bertolucci, C.; Wittbrodt, J. 2015 Cavefish eye loss in response to an early block in retinal differentiation progression Development 142 4 743-752 doi: 10.1242/dev.114629 [Link]
Stemmer, M.; Thumberger, T.; Del Sol Keyer, M.; Wittbrodt, J.; Mateo, J.L. 2015 CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool PLoS One 10 4 e0124633 doi: 10.1371/journal.pone.0124633 [Link]
Tavares, S.; Wirtz, M.; Beier, M.P.; Bogs, J.; Hell, R.; Amancio, S. 2015 Characterization of the serine acetyltransferase gene family of Vitis vinifera uncovers differences in regulation of OAS synthesis in woody plants Front Plant Sci 6 74 doi: 10.3389/fpls.2015.00074 [Link]
Timm, S.; Wittmiss, M.; Gamlien, S.; Ewald, R.; Florian, A.; Frank, M.; Wirtz, M.; Hell, R.; Fernie, A.R.; Bauwe, H. 2015 Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana Plant Cell doi: 10.1105/tpc.15.00105 [Link]
Xu, F.; Huang, Y.; Li, L.; Gannon, P.; Linster, E.; Huber, M.; Kapos, P.; Bienvenut, W.; Polevoda, B.; Meinnel, T.; Hell, R.; Giglione, C.; Zhang, Y.; Wirtz, M.; Chen, S.; Li, X. 2015 Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis Plant Cell 27 5 1547-1562 doi: 10.1105/tpc.15.00173 [Link]
Acehan, D.; Santarella-Mellwig, R.; Devos, D.P. 2014 A bacterial tubulovesicular network J Cell Sci 127 Pt 2 277-280 doi: 10.1242/jcs.137596 [Link]
Althoff, F.; Benzing, K.; Comba, P.; McRoberts, C.; Boyd, D.R.; Greiner, S.; Keppler, F. 2014 Abiotic methanogenesis from organosulphur compounds under ambient conditions Nat Commun 5 4205 doi: 10.1038/ncomms5205 [Link]
Bluhm, K.; Otte, J.C.; Yang, L.; Zinsmeister, C.; Legradi, J.; Keiter, S.; Kosmehl, T.; Braunbeck, T.; Strahle, U.; Hollert, H. 2014 Impacts of different exposure scenarios on transcript abundances in Danio rerio embryos when investigating the toxicological burden of riverine sediments PLoS One 9 9 e106523 doi: 10.1371/journal.pone.0106523 [Link]
Busquet, F.; Strecker, R.; Rawlings, J.M.; Belanger, S.E.; Braunbeck, T.; Carr, G.J.; Cenijn, P.; Fochtman, P.; Gourmelon, A.; Hubler, N.; Kleensang, A.; Knobel, M.; Kussatz, C.; Legler, J.; Lillicrap, A.; Martinez-Jeronimo, F.; Polleichtner, C.; Rzodeczko, H.; Salinas, E.; Schneider, K.E.; Scholz, S.; van den Brandhof, E.-J.; van der Ven, L.T.M.; Walter-Rohde, S.; Weigt, S.; Witters, H.; Halder, M. 2014 OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing Regul Toxicol Pharmacol 69 3 496-511 doi: 10.1016/j.yrtph.2014.05.018 [Link]
Cao, M.-J.; Wang, Z.; Zhao, Q.; Mao, J.-L.; Speiser, A.; Wirtz, M.; Hell, R.; Zhu, J.-K.; Xiang, C.-B. 2014 Sulfate availability affects ABA levels and germination response to ABA and salt stress in Arabidopsis thaliana Plant J 77 4 604-615 doi: 10.1111/tpj.12407 [Link]
Centanin, L.; Ander, J.-J.; Hoeckendorf, B.; Lust, K.; Kellner, T.; Kraemer, I.; Urbany, C.; Hasel, E.; Harris, W.A.; Simons, B.D.; Wittbrodt, J. 2014 Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina Development 141 18 3472-3482 doi: 10.1242/dev.109892 [Link]
Centanin, L.; Wittbrodt, J. 2014 Retinal neurogenesis Development 141 2 241-244 doi: 10.1242/dev.083642 [Link]
Daum, G.; Medzihradszky, A.; Suzaki, T.; Lohmann, J.U. 2014 A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis Proc Natl Acad Sci U S A 111 40 14619-14624 doi: 10.1073/pnas.1406446111 [Link]
Devos, D.P. 2014 Re-interpretation of the evidence for the PVC cell plan supports a Gram-negative origin Antonie Van Leeuwenhoek 105 2 271-274 doi: 10.1007/s10482-013-0087-y [Link]
Devos, D.P.; Graf, R.; Field, M.C. 2014 Evolution of the nucleus Curr Opin Cell Biol 28 8-15 doi: 10.1016/ [Link]
Devos, D.P. 2014 PVC bacteria: variation of, but not exception to, the Gram-negative cell plan Trends Microbiol 22 1 14-20 doi: 10.1016/j.tim.2013.10.008 [Link]
Ding, Y.; Robinson, D.G.; Jiang, L. 2014 Unconventional protein secretion (UPS) pathways in plants Curr Opin Cell Biol 29 107-115 doi: 10.1016/ [Link]
Ding, Y.; Wang, J.; Chun Lai, J.H.; Ling Chan, V.H.; Wang, X.; Cai, Y.; Tan, X.; Bao, Y.; Xia, J.; Robinson, D.G.; Jiang, L. 2014 Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals Mol Biol Cell 25 3 412-426 doi: 10.1091/mbc.E13-10-0586 [Link]
Erceg, J.; Saunders, T.E.; Girardot, C.; Devos, D.P.; Hufnagel, L.; Furlong, E.E.M. 2014 Subtle changes in motif positioning cause tissue-specific effects on robustness of an enhancer's activity PLoS Genet 10 1 e1004060 doi: 10.1371/journal.pgen.1004060 [Link]
Gao, C.; Cai, Y.; Wang, Y.; Kang, B.-H.; Aniento, F.; Robinson, D.G.; Jiang, L. 2014 Retention mechanisms for ER and Golgi membrane proteins Trends Plant Sci 19 8 508-515 doi: 10.1016/j.tplants.2014.04.004 [Link]
Gulati, J.; Baldwin, I.T.; Gaquerel, E. 2014 The roots of plant defenses: integrative multivariate analyses uncover dynamic behaviors of gene and metabolic networks of roots elicited by leaf herbivory Plant J 77 6 880-892 doi: 10.1111/tpj.12439 [Link]
Hambleton, E.A.; Guse, A.; Pringle, J.R. 2014 Similar specificities of symbiont uptake by adults and larvae in an anemone model system for coral biology J Exp Biol 217 Pt 9 1613-1619 doi: 10.1242/jeb.095679 [Link]
Hohmann, N.; Schmickl, R.; Chiang, T.-Y.; Lucanova, M.; Kolar, F.; Marhold, K.; Koch, M.A. 2014 Taming the wild: resolving the gene pools of non-model Arabidopsis lineages BMC Evol Biol 14 224 doi: 10.1186/s12862-014-0224-x [Link]
Kiefer, M.; Schmickl, R.; German, D.A.; Mandakova, T.; Lysak, M.A.; Al-Shehbaz, I.A.; Franzke, A.; Mummenhoff, K.; Stamatakis, A.; Koch, M.A. 2014 BrassiBase: introduction to a novel knowledge database on Brassicaceae evolution Plant Cell Physiol 55 1 e3 doi: 10.1093/pcp/pct158 [Link]
Kim, Y.J.; Maizel, A.; Chen, X. 2014 Traffic into silence: endomembranes and post-transcriptional RNA silencing Embo J. 33 9 968-980 doi: 10.1002/embj.201387262 [Link]
Klemens, P.A.W.; Patzke, K.; Trentmann, O.; Poschet, G.; Buttner, M.; Schulz, A.; Marten, I.; Hedrich, R.; Neuhaus, H.E. 2014 Overexpression of a proton-coupled vacuolar glucose exporter impairs freezing tolerance and seed germination New Phytol 202 1 188-197 doi: 10.1111/nph.12642 [Link]
Lanquar, V.; Grossmann, G.; Vinkenborg, J.L.; Merkx, M.; Thomine, S.; Frommer, W.B. 2014 Dynamic imaging of cytosolic zinc in Arabidopsis roots combining FRET sensors and RootChip technology New Phytol 202 1 198-208 doi: 10.1111/nph.12652 [Link]
Loibl, M.; Wunderle, L.; Hutzler, J.; Schulz, B.L.; Aebi, M.; Strahl, S. 2014 Protein O-mannosyltransferases associate with the translocon to modify translocating polypeptide chains J Biol Chem 289 12 8599-8611 doi: 10.1074/jbc.M113.543116 [Link]
Medzihradszky, A.; Schneitz, K.; Lohmann, J.U. 2014 Detection of mRNA expression patterns by nonradioactive in situ hybridization on histological sections of floral tissue Methods Mol Biol 1110 275-293 doi: 10.1007/978-1-4614-9408-9_14 [Link]
Molins, M.P.; Corral, J.M.; Aliyu, O.M.; Koch, M.A.; Betzin, A.; Maron, J.L.; Sharbel, T.F. 2014 Biogeographic variation in genetic variability, apomixis expression and ploidy of St. John's wort (Hypericum perforatum) across its native and introduced range Ann Bot 113 3 417-427 doi: 10.1093/aob/mct268 [Link]
Montesinos, J.C.; Pastor-Cantizano, N.; Robinson, D.G.; Marcote, M.J.; Aniento, F. 2014 Arabidopsis p24delta5 and p24delta9 facilitate Coat Protein I-dependent transport of the K/HDEL receptor ERD2 from the Golgi to the endoplasmic reticulum Plant J 80 6 1014-1030 doi: 10.1111/tpj.12700 [Link]
Papagiannouli, F.; Schardt, L.; Grajcarek, J.; Ha, N.; Lohmann, I. 2014 The Hox gene Abd-B controls stem cell niche function in the Drosophila testis Dev Cell 28 2 189-202 doi: 10.1016/j.devcel.2013.12.016 [Link]
Robinson, D.G. 2014 Trafficking of Vacuolar Sorting Receptors: New Data and New Problems Plant Physiol 165 4 1417-1423 doi: 10.1104/pp.114.243303 [Link]
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Speiser, A.; Haberland, S.; Watanabe, M.; Wirtz, M.; Dietz, K.-J.; Saito, K.; Hell, R. 2014 The significance of cysteine synthesis for acclimation to high light conditions Front Plant Sci 5 776 doi: 10.3389/fpls.2014.00776 [Link]
Stauffer, E.; Maizel, A. 2014 Post-transcriptional regulation in root development Wiley Interdiscip Rev RNA 5 5 679-696 doi: 10.1002/wrna.1239 [Link]
Symmons, O.; Uslu, V.V.; Tsujimura, T.; Ruf, S.; Nassari, S.; Schwarzer, W.; Ettwiller, L.; Spitz, F. 2014 Functional and topological characteristics of mammalian regulatory domains Genome Res 24 3 390-400 doi: 10.1101/gr.163519.113 [Link]
Vaddepalli, P.; Herrmann, A.; Fulton, L.; Oelschner, M.; Hillmer, S.; Stratil, T.F.; Fastner, A.; Hammes, U.Z.; Ott, T.; Robinson, D.G.; Schneitz, K. 2014 The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana Development 141 21 4139-4148 doi: 10.1242/dev.113878 [Link]
Vermeer, J.E.M.; von Wangenheim, D.; Barberon, M.; Lee, Y.; Stelzer, E.H.K.; Maizel, A.; Geldner, N. 2014 A spatial accommodation by neighboring cells is required for organ initiation in Arabidopsis Science 343 6167 178-183 doi: 10.1126/science.1245871 [Link]
Vilches-Barro, A.; Maizel, A. 2014 Talking through walls: mechanisms of lateral root emergence in Arabidopsis thaliana Curr. Opin. Plant Biol. 23c 31-38 doi: 10.1016/j.pbi.2014.10.005 [Link]
von Wangenheim, D.; Daum, G.; Lohmann, J.U.; Stelzer, E.K.; Maizel, A. 2014 Live imaging of Arabidopsis development Methods Mol Biol 1062 539-550 doi: 10.1007/978-1-62703-580-4_28 [Link]

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