Ruprecht-Karls-Universität Heidelberg
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Dr. Sergio P. Acebrón

Dr. Sergio P. Acebrón
Dr. Sergio P. Acebrón
Im Neuenheimer Feld 230
69120 Heidelberg
Fon 06221-545257
Fax 06221-545678
ed.grebledieh-inu.soc TEA norbeca.oigres

 

Our research focuses on how somatic and stem cells integrate extracellular signals to modulate their fate

The architecture, homeostasis and function of the organs is defined at the cellular level by the integration of a myriad of molecular signals. In our lab, we study how stem cells, progenitor cells, and somatic cells integrate extracellular signals and how these cascades define celfate. We focus on unravelling the molecular mechanisms underlying signal transduction, specially in ther context of the Wnt signalling pathway and mitosis. To address these questions we integrate cutting edge imaging and genome editing with detailed molecular analyses in mouse models, ex vivo cultured neural progenitor cells, organoids, as well as cell lines. 

Figure 1: We analyse cell signalling in vivo by studying mouse models (upper left); and in vitro by using cultured somatic cells (upper middle) and cell extracts (upper right). We complement our studies with ex vivo models such as intestinal organoids (lower left); embryonic stem cells (colony; lower middle), and neural progenitor cells (neurosphere; lower right).

 

Lab topics:

Cell signalling & mitosis

A fundamental open question in cell biology, development, and physiology is how cells are guided through mitosis to place specific daughter cells at defined positions. During the complex voyage of building tissues, cells integrate intrinsic factors, as well as extrinsic cues from their niches to modulate the progression, symmetry, orientation, and fate of their divisions. Misregulation of these processes is associated with loss of the cellular hierarchies and can ultimately lead to disease, notably cancer. We aim to unravel how different signalling pathways shape the cell fate during development and tissue renewal by modulating cell division.

 

Stem cell & cancer biology

The fate of adult stem cells is determined by the integration of extracellular signals released from their niches. For example, Wnt ligands are essential for stem cell maintenance and tissue homeostasis across many organs. We study the transduction of Wnt signals, notably in mammalian adult stem cells of the adrenal gland and the gut. We aim to identify and characterise signalling components, interactions and modifications that play key roles in stem cell renewal, and whose misregulation can lead to cancer.

 

Signal transduction & crosstalk

The extracellular signalling pathways are notorious for their cross talk, but it is still not well understood how stem and progenitor cells integrate different extracellular signals from a multi-signalling niche to modulate their fate and behaviour. We aim to characterise the fundamental molecular hubs where these signals converge.

Open positions:

We have open positions for a PhD student in stem cell biology and a technician/lab manager (See below). Please contact Sergio for inquiries for open positions in the lab, as well as master projects and lab rotations.

Open position: Lab Manager / Research Technician

Mitarbeiter/in im technischen Dienst (Biologisch-technische Assistent/in)

  • Application deadline: August 31, 2017
  • Start of the project: October, 2017 or as soon as possible
  • Type of position: Full-time, German TV-L scale (depending of qualifications)
  • Location: University of Heidelberg (Germany)
  • Application by email: Dr Sergio Acebron,  sergio.acebron@cos.uni-heidelberg.de

We are recruiting a lab manager / technician to support our newly established group at the Centre for Organismal Studies (COS) at Heidelberg University. We investigate the mechanisms of signalling transduction, especially in stem cells, by studying cell culture models, ex vivo cultured organoids, as well as mouse models. We are integrated in the new consortium SFB1324 on Wnt signalling.

We are looking for a lab manager / technician with strong organisational skills and research experience in mouse work and molecular biosciences. The candidate will plan, conduct and assist to mouse experiments in collaboration with members of the group. Responsibilities will also include oversight of the lab’s resources and equipment, serving as a contact point with local services/facilities, introducing new team members to the operations/practices of the lab, and acting as a contact point for lab safety. S/he will also be encouraged to participate in research and outreach activities, depending on interests. 

S/he will be fully integrated in the Acebron lab participating in lab meetings and retreats, and should be able to communicate fluently in English and German. S/he will interact with other members of the team and respond to their feedback to resolve any organisational issues in the lab. To fulfil this role, s/he will be given a high degree of responsibility and freedom, as well as any required training.

The lab manager / technician will receive a salary and health/social security coverage according to German TV-L standards (salary scale depending on qualifications and experience). If qualified equally, disabled people and women are given priority. The contract will be initially for one year, starting as soon as possible, with possible extensions for the entire duration of the project until 30.6.2021.

Applicants should send a CV and brief letter of motivation in English or German to Sergio Acebron (sergio.acebron@cos.uni-heidelberg.de ), before August 31, 2017. They should also provide a letter of recommendation, or the contact information of a referee. 

 


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