Ruprecht-Karls-Universität Heidelberg
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Dr. Guido Grossmann

Dr. Guido Grossmann
Dr. Guido Grossmann
Im Neuenheimer Feld 230
69120 Heidelberg
Fon +49 6221 54-5612
Fax +49 6221 54-5678
ed.grebledieh-inu.soc TEA nnamssorg.odiug

For more detailed information please visit our lab website.


The plasma membrane of cells acts as the interface between the inner living world and the environment. Neighboring cells or substrates, biotic or abiotic stresses, toxins or nutrients are perceived at the plasma membrane, eliciting intracellular responses.

In return, these responses manifest in dynamic reorganization of the membrane itself, which is a key requirement for the establishment of cell polarity.

Our lab uses plants as a model system to study mechanisms that allow the plasma membrane to accomplish the interface function by sensing and processing information about its environment and to polarize the cell by forming subcompartments for directed transport of nutrients and metabolites.

We are focussing on the following processes:

  • control of lateral diffusion of proteins at the plasma membrane,
  • impact of cell wall and cytoskeleton on membrane organization,
  • dynamics and coordination of the establishment of cell polarity,
  • signaling processes in response to signal perception.


Tool development

Microfluidic imaging platforms

The RootChip is an integrated cultivation, perfusion, and imaging device for Arabidopsis roots. It allows growing roots for several days directly at the microscope, precise control over the microenvironment, and pulsed treatments.




Genetically encoded fluorescent biosensors

Sensors for nutrients like sugars, second messengers such as calcium, or hormones allow the visualization of molecule dynamics in a living organism at high temporal and spatial resolution.





Open positions

Please contact Guido Grossmann for inquiries about open positions in the lab.

  • We currently have openings for master projects, rotations and internships.


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