Ruprecht-Karls-Universität Heidelberg
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Developmental Neurobiology

Prof. Dr. G. Elisabeth Pollerberg

Prof. Dr. G. Elisabeth Pollerberg
Prof. Dr. G. Elisabeth Pollerberg
Im Neuenheimer Feld 232
69120 Heidelberg
Fon +49 6221 54-6370/6371
Fax +49 6221 54-6375
ed.grebledieh-inu.soc TEA grebrellop.e.g

Molecular Basis of Axonal Orientation

Current Research

We study the cellular and molecular processes underlying the formation of the nervous system. In particular, we are interested in interactions of growing axons with their environment and the transformation of such interactions into directed growth.

Using various in vitro, in vivo and in ovo systems of the chick and mouse retina and spinal ganglia (embryonic to adult), we investigate the potential role of cell adhesion molecules for growth and regeneration of axons.  We also study the role of the cytoskeletal structures in the axon, characterising known and novel components. In addition, the signalling components mediating between cell membrane and growth cone cytoskeleton are investigated.

For our studies, we make use of biochemical, cell biological and moleculer biological assays such as high-end cell (co-)culture systems, laser inactivation (CALI), cellular displays, yeast-2-hybrid assays, knock down, overexpression, in ovo electroporation, viral transfection and nucleofection etc..

Future Projects and Goals

Cell adhesion molecules, cytoskeletal components and intracellular signalling components will be further investigated for their role in axonal growth and regeneration. In particular we want to study their functions in histotypic environment (e.g. in organ culture) and in vivo. For this, we for example investigate the retina of transgenic mouse embryos mutated in the genes of our interest. Our aim is to understand the „wiring of the brain“ during higher vertebrate embryogenesis better and to contribute to the development of novel therapeutic approaches.

 

Open Positions


/var/www/cos/ / http://www.cos.uni-heidelberg.de/ Prof. Dr. G. Elisabeth Pollerberg _e