Ruprecht-Karls-Universität Heidelberg
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Dr. Jan Felix Evers

Dr. Jan Felix Evers
Im Neuenheimer Feld 329
69120 Heidelberg
Fon +49 6221 546469
ed.grebledieh-inu.soc TEA sreve.xilef-naj

Coordinated behaviour is the result of successful neuronal network assembly. During embryogenesis, excitability and connectivity of neurons must be carefully adjusted so that functional networks can arise. We investigate how individual neurons select from the vast number of potential partner neurons and form synapses with only a few in the inherently variable environment of the central nervous system.

Using the locomotor system of Drosophila melanogaster, we develop and apply a number of cutting edge techniques to uncover the molecular mechanisms that regulate developmental plasticity and functional homeostatsis: 1) live 3-dimensional imaging of dynamic growth and synaptogenesis of individual pairs of neurons; 2) 3-dimensional computational analysis of neuronal structure and interaction with synaptic partners; 3) live imaging of neurogenesis and neuronal differentiation with light sheet microscopy; 4) optogenetically inducible labeling of endogenous synaptic proteins in individual cells with a conditional marker.

 

Open Positions

Please contact Jan Felix Evers for inquiries for open positions in the lab. 

 

PhD project (3yrs)

We are currently looking for a highly motivated PhD student interested in investigating synapse formation in the central nervous system at the molecular level. The successful candidate will use molecular genetics, confocal live imaging techniques and computational 4D image analysis to uncover the molecular mechanisms that regulate the assembly of the synaptic scaffold during circuit formation and synaptic maintenance in the locomotor system in Drosophila embryos and larvae. Experience with molecular biology and the analysis of complex image data would be beneficial.

 

We have openings for master projects and lab rotations. 

 


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