Dr. Lucia Poggi
Dr. Lucia Poggi
Im Neuenheimer Feld 230
Fon +49 6221 54-6494
Fax +49 6221 54-5639
ed.grebledieh-inu.soc TEA iggop.aicul
Generation of neuronal diversity by asymmetric cell division requires coordinated regulation of cell proliferation and cell fate specification. In my group we aim to understand the complex networks integrating these processes in vivo. We take advantage of the easily accessible retinal neuroepithelium of the developing zebrafish embryo and employ one- or two-photon laser scanning microscopy to track the fate of individual, molecularly labelled, retinal progenitor cells. We found that some of these cells undergo reproducible asymmetric divisions generating one dividing progenitor and one specific subtype of neuron. We therefore established a suitable lineage model where we can study underlying molecular/cellular mechanisms of asymmetric cell division and neuronal fate specification in vivo.
Building on this, we are developing an integrated research program combining live imaging with transgenesis, cell biology and genome editing approaches. We recently uncovered that the F-actin binding protein Anillin, essential cleavage furrow and midbody component in animal cells, is an important linking factor for balancing cell proliferation and differentiation in asymmetric neurogenic cell divisions. We are continuing this study to understand the molecular processes underlying Anillin role in asymmetric cell division, and their link to signalling pathways such as the Notch and Hippo pathway.