Dr. Lucia Poggi
Dr. Lucia Poggi
Im Neuenheimer Feld 230
Fon +49 6221 54-6494
Fax +49 6221 54-5639
ed.grebledieh-inu.soc TEA iggop.aicul
How do different but lineally related neurons develop from divisions of a common progenitor cell of origin? What is their molecular/functional relationship in the context of neural circuit formation? Answer to these basic questions, we think, will provide further clues as to the understanding of re-programming potential of neuronal cells in vivo, fundamental for regenerative therapeutic approaches.
We use the zebrafish embryonic retina as a vertebrate model system for addressing this challenge, whereby in this system we can apply in vivo time-lapse profiling of individual retinal cells while concurrently visualising molecular events in a normally developing environment. Our established cell lineage model is the retinal ganglion cells (RGCs) lineage. RGCs are the output neurons of the retina; they are the first neurons to be born and also the first cells to die in glaucoma and other optic neuropathies in human. RGCs tend to arise by asymmetric divisions of retinal progenitor cells.
Ongoing projects in the lab are emploing this lineage paradigm in combination with genetic, systematic and computational approaches to elucidate 1) relative importance of intrinsic and extrinsic cues in the regulation of RGC number and subtype diversification in vivo 2) mechanisms of inheritance of intrinsic cell fate determinants during symmetric and asymmetric cell division 3) functional and molecular relationship between lineage-related retinal subtypes during retinal circuit formation.
For Publications visit the link:
EMBO practical course “Imaging of Neural Development in Zebrafish”
8-15 September 2013, Karlsruhe, Germany