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Stem Cell Biology

SFB 873

Maintenance and Differentiation of Stem Cells
in Development and Disease

 

A01 A02 A03 B01 B02 B03 Z02 Z03 Z04
A06 A11 A12 B04 B06 B07
A13 A14   B08 B09 B11
      B12

 

A01 Thomas Holstein

Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079


Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T and Holstein TW
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Nat Commun. 2014 Dec 23;5:5536. doi: 10.1038/ncomms6536.


Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW
Nodal signalling determines biradial asymmetry in Hydra
Nature. 2014 Nov 6;515(7525):112-5. doi: 10.1038/nature13666


Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission
BMC Biol. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2.


 

A02 Bruce Edgar

Jin Y, Ha N, Forés M, Xiang J, Gläßer C, Maldera J, Jiménez G, Edgar BA
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
PLoS Genet. 2015 Dec 18;11(12):e1005634. doi: 10.1371/journal.pgen.1005634


Patel PH, Dutta D, Edgar BA
Niche appropriation by Drosophila intestinal stem cell tumours
Nat Cell Biol. 2015 Sep;17(9):1182-92. doi: 10.1038/ncb3214


Dutta D, Buchon N, Xiang J, Edgar BA
Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations
Curr Protoc Stem Cell Biol. 2015 Aug 3;34:2F.2.1-14. doi: 10.1002/9780470151808.sc02f02s34


Dutta D, Dobson AJ, Houtz PL, Gläßer C, Revah J, Korzelius J, Patel PH, Edgar BA, Buchon N
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
Cell Rep. 2015 Jul 14;12(2):346-58. doi: 10.1016/j.celrep.2015.06.009


Zhou J, Florescu S, Boettcher AL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA, Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017


 

A03 Joachim Wittbrodt

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug; 45:28-33. doi: 10.1016/j.gde.2017.02.002


Gutierrez-Triana JA, Mateo JL, Ibberson D, Ryu S,Wittbrodt J
iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins
Development. 2016 Nov 15. doi: 10.1242/dev.139261


Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development. 2016 Oct 1. DOI: 10.1242/dev.134098


Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706


Stemmer M, Schuhmacher LN, Foulkes NS, Bertolucci C, Wittbrodt J
Cavefish eye loss in response to an early block in retinal differentiation progression
Development. 2015 Feb 15;142(4):743-52. doi: 10.1242/dev.114629


Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892


Sinn R, Peravali R, Heermann S, Wittbrodt J
Differential responsiveness of distinct retinal domains to Atoh7
Mech Dev. 2014 Aug;133:218-29. doi: 10.1016/j.mod.2014.08.002


 

A06 Michael Boutros

Zhou J, Edgar BA and Boutros M
ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration
Nat Commun. 2017; 8: 14289. online 2017 Mar 8. doi: 10.1038/ncomms14289


Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan 10;10(461). pii: eaah6829. doi: 10.1126/scisignal.aah6829


Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov. Doi: 10.1016/j.scr.2016.10.010


Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell. 2016 Jan 11. doi: 10.1016/j.devcel.2015.12.015


Brunk F, Augustin I, Meister M, Boutros M, Kyewski B
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
J Immunol. 2015 Dec 1;195(11):5261-71. doi: 10.4049/jimmunol.1501265


Erdmann G, Suchanek M, Horn P, Graf F, Volz C, Horn T, Zhang X, Wagner W, Ho AD, Boutros M
Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Genome Med. 2015 May 17;7(1):46. doi: 10.1186/s13073-015-0170-2


Zhou J, Florescu S, Boettcher A-LL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA and Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017


 

A11 Lázaro Centanin

Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development. 2017 Feb15 doi: 10.1242/dev.142752


Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892


 

A12 Claudia Scholl, Hanno Glimm

Giessler KM, Kleinheinz K, Huebschmann D, Balasubramanian GP, Dubash TD, Dieter SM, Siegl C, Herbst F, Weber S, Hoffmann CM, Fronza R, Buchhalter I, Paramasivam N, Eils R, Schmidt M, von Kalle C, Schneider M, Ulrich A, Scholl C, Fröhling S, Weichert W, Brors B, Schlesner M, Ball CR, Glimm H
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
J Exp Med. 2017 Jul 3;214(7):2073-2088. doi: 10.1084/jem.20162017


Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J, Glimm H
Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts
EMBO Mol Med. 2017 Jul;9(7):918-932. doi: 10.15252/emmm.201607354


Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Blood. 2016 Jun 9. doi: 10.1182/blood-2015-11-683581


Dubash TD, Hoffmann CM, Oppel F, Giessler KM, Weber S, Dieter SM, Hüllein J, Zenz T, Herbst F, Scholl C, Weichert W, Werft W, Benner A, Schmidt M, Schneider M, Glimm H, Ball CR
Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells
Cancer Lett. 2016 Feb 28. doi: 10.1016/j.canlet.2015.11.037


 

A13 Christoph Lutz

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May 26. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. doi: 10.1038/ncb3493


Wang W, Foerner E, Buss E, Jauch A, Eckstein V, Wuchter P, Ho AD, Lutz C
Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients
Leuk Lymphoma. 2016 Oct 13:1-9. DOI: 10.1080/10428194.2016.1236378.


Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct 12. DOI: 10.1186/s13062-016-0154-1


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


 

A14 Gislene Pereira

Caydasi AK, Khmelinskii A, Duenas-Sanchez R, Kurtulmus B, Knop M, Pereira G
Temporal and compartment-specific signals coordinate mitotic exit with spindle position
Nat Commun. 2017 Jan 24. doi: 10.1038/ncomms14129


Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713


Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033


 

B01 Jan Lohmann

Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 2016 Sep 12. doi: 10.1016/j.cub.2016.07.070.


Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023


Schuster C, Gaillochet C, Lohmann JU
Arabidopsis HECATE genes function in phytohormone control during gynoecium development
Development. 2015 Oct 1. doi: 10.1242/dev.120444


Gaillochet C, Lohmann JU
The never-ending story: from pluripotency to plant developmental plasticity
Development. 2015 Jul 1;142(13):2237-49. doi: 10.1242/dev.117614


Forner J, Pfeiffer A, Langenecker T, Manavella P, Lohmann JU
Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases
PLoS One. 2015 Mar 30;10(3):e0121056. doi: 10.1371/journal.pone.0121056


Gaillochet C, Daum G, Lohmann JU
O cell, where art thou? The mechanisms of shoot meristem patterning
Curr Opin Plant Biol. 2015 Feb;23:91-7. doi: 10.1016/j.pbi.2014.11.002


Yang H, von der Fecht-Bartenbach J, Friml J, Lohmann JU, Neuhäuser B and Ludewig U
Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with ammonium as the sole nitrogen source
Functional Plant Biology 42(3) 239-251 DOI: 10.1071/FP14171. Published: 24 October 2014


Daum G, Medzihradszky A, Suzaki T, Lohmann JU
A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14619-24. doi: 10.1073/pnas.1406446111


Vilarrasa-Blasi J, González-García MP, Frigola D, Fàbregas N, Alexiou KG, López-Bigas N, Rivas S, Jauneau A, Lohmann JU, Benfey PN, Ibañes M, Caño-Delgado AI
Regulation of plant stem cell quiescence by a brassinosteroid signaling module
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020


 

B02 Ingrid Lohmann

Schardt L, Ander JJ, Lohmann I, Papagiannouli F
Stage-specific control of niche positioning and integrity in the Drosophila testis
Mech Dev. 2015 Nov. doi: 10.1016/j.mod.2015.07.009


Papagiannouli F, Lohmann I
Stage-specific control of niche architecture in the Drosophila testis by the posterior Hox gene Abd-B
Comput Struct Biotechnol J. 2015 Jan 21. doi: 10.1016/j.csbj.2015.01.001


Papagiannouli F, Lohmann I
The Male Stem Cell Niche: insights from Drosophila and mammalian model systems, Tissue Specific Stem Cell Niche (“Stem Cell Biology and Regenerative Medicine” Series), Dr. Kursad Turksen (Ed.)
ISSN: 2196-8985, Springer Verlag (accepted; in print) (www.springer.com/series/7896?detailsPage=titles)


Papagiannouli F, Schardt L, Grajcarek J, Ha N, Lohmann I
The Hox gene Abd-B controls stem cell niche function in the Drosophila testis
Dev Cell. 2014 Jan 27. doi: 10.1016/j.devcel.2013.12.016.


Papagiannouli F, Lohmann I
Shaping the niche: lessons from the Drosophila testis and other model systems
Biotechnol J. 2012 Jun. doi: 10.1002/biot.201100352


 

B03 Christof Niehrs

Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C
Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112


Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A
Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031


Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037


 

B04 Andreas Trumpp

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018


Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. doi: 10.1038/ncb3493


Sommerkamp P. and Trumpp A
Metabolic cues for hematopoietic stem cells
Science 02 Dec 2016: Vol. 354, Issue 6316, pp. 1103-1104, DOI: 10.1126/science.aal3466


Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenmann RN, Trumpp A, Shinohara T
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal
Genes Dev. 2016 Dec 1. doi: 10.1101/gad.287045.116


Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
Blood. 2016 Sep 1;doi: 10.1182/blood-2015-11-679167


Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033


Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J
Selection and dynamics of embryonic stem cell integration into early mouse embryos
Development. 2016 Jan 1;143(1):24-34. doi: 10.1242/dev.124602


Morrison G, Scognamiglio R, Trumpp A, Smith A
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification
EMBO J. 2016 Jan 1;35(3):356-68. doi: 10.15252/embj.201592116


Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013


Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition
Aging (Albany NY). 2015 Nov;7(11):911-27


Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MAG, Williams DA, Trumpp A and Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131


Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E,Weichert W,Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR and Trumpp A
Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin
Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015


 

B06 Hellmut Augustin

Augustin HG, Koh GY
Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology
Science. 2017 Aug 3. pii: eaal2379. doi: 10.1126/science.aal2379


Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG
Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nat Commun. 2017 Jul 18;8:16106. doi: 10.1038/ncomms16106


Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
EMBO Mol Med. 2017 Jun;9(6):741-749. doi: 10.15252/emmm.201607222


Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG
Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):495-505. doi: 10.1161/ATVBAHA.116.308455


Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation
Sci Signal. 2016 Apr 26. doi: 10.1126/scisignal.aad3812


Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell. 2016 Jan 11;36(1):79-93. doi: 10.1016/j.devcel.2015.12.015


Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Freire Valls A, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG
The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024


Korn C, Augustin HG
Mechanisms of Vessel Pruning and Regression
Dev Cell. 2015 Jul 6;34(1):5-17. doi: 10.1016/j.devcel.2015.06.004.


 

B07 Motomu Tanaka, Anthony D. Ho

Hörnig M, Nakahata M, Linke P, Yamamoto A, Veschgini M, Kaufmann S, Takashima Y, Harada A, and Tanaka M
Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions
Sci Rep. 2017 Aug 9;7(1):7660. doi: 10.1038/s41598-017-07934-x


Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress
Cell Death Dis. 2016 Nov 10. doi: 10.1038/cddis.2016.342


Wuchter P, Vetter M, Saffrich R, Diehlmann A, Bieback K, Ho AD, Horn P
Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells
Exp Hematol. 2016 Jun doi: 10.1016/j.exphem.2016.02.004


Frank V, Kaufmann S, Wright R, Horn P, Yoshikawa HY, Wuchter P, Madsen J, Lewis AL, Armes SP, Ho AD, Tanaka M
Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency
Sci Rep. 2016 Apr 15;6:24264. doi: 10.1038/srep24264.


Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T, Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); doi: 10.1063/1.4943402


Wuchter P, Saffrich R, Giselbrecht S, Nies C, Lorig H, Kolb S, Ho AD, Gottwald E
Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells
Cell Tissue Res. 2016 Jan 30. doi:10.1007/s00441-015-2348-8


Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP, Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b


Monzel C, Veschgini M, Madsen J, Lewis AL, Armes SP, Tanaka M
Fine Adjustment of Interfacial Potential between pH-Responsive Hydrogels and Cell-Sized Particles
Langmuir. 2015 Aug 11;31(31):8689-96. doi: 10.1021/acs.langmuir.5b01896


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD
Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells
Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370


Stiehl T, Baran N, Ho AD, Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508


Malcherek G, Jin N, Hückelhoven AG, Mani J, Wang L, Gern U, Diehlmann A, Wuchter P, Schmitt A, Chen B, Ho AD, Schmitt M
Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells
Leukemia. 2014 Dec;28(12):2388-94. doi: 10.1038/leu.2014.273


Wuchter P, Leinweber C, Saffrich R, Hanke M, Eckstein V, Ho AD, Grunze M, Rosenhahn A
Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells
Cell Tissue Res. 2014 Feb. doi: 10.1007/s00441-013-1759-7


Ludwig A, Saffrich R, Eckstein V, Bruckner T, Wagner W, Ho AD, Wuchter P
Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor
Cytotherapy. 2014 Jan doi: 10.1016/j.jcyt.2013.07.007


 

B08 Anna Marciniak- Czochra

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May 26. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Dev Cell. 2016 Nov 7. doi: 10.1016/j.devcel.2016.10.002


Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct 12. DOI: 10.1186/s13062-016-0154-1


Busse JE, Gwiazda P, Marciniak-Czochra A
Mass concentration in a nonlocal model of clonal selection
J Math Biol. 2016 Mar 3. doi: 10.1007/s00285-016-0979-3


Stiehl T, Baran N, Ho AD and Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508


 

B09 Ana Martin- Villalba

Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A
Revealing Age-Related Changes of Adult Hippocampal Neurogenesis
online Feb. 27, 2017. doi: http://dx.doi.org/10.1101/112128


Baser A, Skabkin M, Martin-Villalba A
Neural Stem Cell Activation and the Role of Protein Synthesis
Brain Plasticity. Published: 7 January 2017. DOI: 10.3233/BPL-160038


Llorens-Bobadilla E, Martin-Villalba A
Adult NSC diversity and plasticity: the role of the niche
Curr Opin Neurobiol. 2016 Dec 12. doi: 10.1016/j.conb.2016.11.008


Bifari F, Decimo I, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Cell Stem Cell. 2016 Nov 17. doi: 10.1016/j.stem.2016.10.020


Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Dev Cell. 2016 Nov 7. doi: 10.1016/j.devcel.2016.10.002


Drachsler M, Kleber S, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
Cell Death Dis. 2016 Apr 28. doi: 10.1038/cddis.2016.102


Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
Cell Stem Cell. 2015 Sep 3. doi: 10.1016/j.stem.2015.07.002


Seib DR, Martin-Villalba A
Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Gerontology. 2015;61(4):327-35. doi: 10.1159/000368575. Issue release date: June 2015


 

B11 Hans-Reimer Rodewald

Höfer T, Rodewald HR
Output without input: the lifelong productivity of hematopoietic stem cells
Curr Opin Cell Biol. 2016 Dec;43:69-77. doi: 10.1016/j.ceb.2016.08.003


Busch K, Rodewald HR
Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different
Curr Opin Hematol. 2016 Jul doi: 10.1097/MOH.0000000000000250


Höfer T, Busch K, Klapproth K, Rodewald HR
Fate Mapping and Quantitation of Hematopoiesis In Vivo
Annu Rev Immunol. 2016 May 20. doi: 10.1146/annurev-immunol-032414-112019


Rode I, Martins VC, Küblbeck G, Maltry N, Tessmer C, Rodewald HR
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
J Immunol. 2015 Dec 15;195(12):5678-87. doi: 10.4049/jimmunol.1502010


Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Freire Valls A, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG
The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024


Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T and Rodewald HR
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
Nature. 2015 Feb 26;518(7540):542-6. doi: 10.1038/nature14242


Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F and Rodewald HR
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Nature. 2015 Feb 26;518(7540):547-51. doi: 10.1038/nature13989


 

B12 Thomas Greb

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug;45:28-33. doi: 10.1016/j.gde.2017.02.002


Brackmann K, Jouannet V, Qi J, Schlamp T, Grünwald K, Sanchez P, Greb T
Spatial specificity of auxin responses coordinates wood formation
bioRxiv online May 27,2017. doi: https://doi.org/10.1101/142885


Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 2016 Sep 12. doi: 10.1016/j.cub.2016.07.070.


Wallner ES, López-Salmerón V, Greb T
Strigolactone versus gibberellin signaling: reemerging concepts?
Planta. 2016 Jun. doi: 10.1007/s00425-016-2478-6


Gursanscky NR, Jouannet V, Grünwald K, Sanchez P, Laaber-Schwarz M, Greb T
MOL1 is required for cambium homeostasis in Arabidopsis
Plant J. 2016 May. doi: 10.1111/tpj.13169


 

Z02 Volker Eckstein

Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD
Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells
Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370


 

Z03 Ulrike Engel


Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar 6. doi: 10.1038/ncomms14583


Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development. 2017 Feb 15. doi: 10.1242/dev.142752


Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713


Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033


Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP and Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b


 

Z04 Jan Lohmann und Michael Boutros


Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar 6. doi: 10.1038/ncomms14583


Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov. doi: 10.1016/j.scr.2016.10.010


Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023



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