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Plant Molecular Biology

Dr. Trinh Dinh Van

Dr. Trinh Dinh Van
Dr. Trinh Dinh Van


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Nα-terminal acetylation (NTA) of proteins is the transfer of an Acetyl group from Acetyl-CoA to the alpha residue of protein. Very often NTA occurs co-translationally and the acetylated amino acid residue can be Methionine or the adjacent residue after cleaving off the Methionine by Methonine amino peptidase. NTA involves in a lot of processes in the cell such as: protein-protein interaction, protein degradation, golgi targeting and translocation, gene silencing and inner nuclear membrane targeting. So far, five Nα-terminal acetyltransferase (NAT) complexes in yeast and six in human have been identified and characterized.
In Arabidopsis thaliana, a bioinformatic screening with the yeast NATs reveals 31 putative NAT proteins, four of them have been identified as cytosolic NAT complexes which are conserved to yeast and human. In addition, we demonstrated the existence of N-terminal acetylated protein in plastids which are nuclear encoded. This result indicated that plants can post-translationally acetylate protein at their N-termini in plastids. In my project, I want to localize some putative NAT proteins and identify the novel NAT complexes in Arabidopsis thaliana focusing in the candidates that’s homologous to Sc. Naa40 and hNaa60 and the organelle-localized candidates.

/var/www/cos/ / http://www.cos.uni-heidelberg.de/ Dr. Trinh Dinh Van _e