Wittbrodt labPublications

Pakari K, Wittbrodt J, Thumberger T

De novo PAM generation to reach initially inaccessible target sites for base editing

Medert R, Thumberger T, Tavhelidse-Suck T, Hub T, Kellner T, Oguchi Y, Dlugosz S, Zimmermann F, Wittbrodt J, Freichel M. Medert R, Thumberger T, Tavhelidse-Suck T, Hub T, Kellner T, Oguchi Y, Dlugosz S, Zimmermann F, Wittbrodt J, Freichel M

Efficient single copy integration via homology-directed repair (scHDR) by 5'modification of large DNA donor fragments in mice

Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T

Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

Cornean A, Gierten J, Welz B, Mateo JL, Thumberger T,  Wittbrodt J

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Thumberger T, Tavhelidse-Suck T,  Gutierrez-Triana JA, Cornean A,  Medert R, Welz B,Freichel M, Wittbrodt J

Boosting targeted genome editing using the hei-tag

Leger A, Brettell I, Monahan J, Barton C, Wolf N, Kusminski N, Herder C, Aadepu N, Becker C, Gierten J, Hammouda OT, Hasel E, Lischik C, Lust K, Sokolova N, Suzuki R, Tavhelidse T, Thumberger T, Tsingos E, Watson P, Welz B, Naruse K, Loosli F, Wittbrodt J, Birney E, Fitzgerald T

Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel.

Fitzgerald T, Brettell I, Leger A, Wolf N, Kusminski N, Monahan J, Barton C, Herder C, Aadepu N, Gierten J, Becker C, Hammouda OT, Hasel E, Lischik C, Lust K, Sokolova N, Suzuki R, Tsingos E, Tavhelidse T, Thumberger T, Watson P, Welz B, Khouja N, Naruse K, Birney E, Wittbrodt J, Loosli F. 

The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

Aghaallaei N, Agarwal R, Benjaminsen J, Lust K, Bajoghli B, Wittbrodt J, Feijoo CG

Antigen-Presenting Cells and T Cells Interact in a Specific Area of the Intestinal Mucosa Defined by the Ccl25-Ccr9 Axis in Medaka

Hammouda OT, Wu MY,  Kaul V, Gierten J, Thumberger T, Wittbrodt J

In vivo identification and validation of novel potential predictors for human cardiovascular diseases

Aghaallaei N, Dick AM, Tsingos E, Inoue D, Hasel E, Thumberger T, Toyoda A, Leptin M, Wittbrodt J, Bajoghli B.

αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals

Zilova L, Weinhardt V, Tavhelidse T, Schlagheck C, Thumberger T, Wittbrodt J.

Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

Gücüm S, Sakson R, Hoffmann M, Grote V, Becker C, Pakari K, Beedgen L, Thiel C, Rapp E, Ruppert T, Thumberger T, Wittbrodt J.

A patient-based medaka alg2 mutant as a model for hypo-N-glycosylation

Wagner N, Beuttenmueller F, Norlin N, Gierten J, Boffi JC, Wittbrodt J, Weigert M, Hufnagel L, Prevedel R, Kreshuk A.

Deep learning-enhanced light-field imaging with continuous validation

Cirksena K, Hütte HJ, Shcherbakova A, Thumberger T, Sakson R, Weiss S, Jensen LR, Friedrich A, Todt D, Kuss AW, Ruppert T, Wittbrodt J, Bakker H, Buettner FFR.

The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development

Becker C, Lust K, Wittbrodt J.

Igf signaling couples retina growth with body growth by modulating progenitor cell division

Meyer HV, Dawes TJW, Serrani M, Bai W, Tokarczuk P, Cai J, de Marvao A, Henry A, Lumbers RT, Gierten J, Thumberger T, Wittbrodt J, Ware JS, Rueckert D, Matthews PM, Prasad SK, Costantino ML, Cook SA, Birney E, O'Regan DP.

Genetic and functional insights into the fractal structure of the heart

Nature

2020

Lösel PD, van de Kamp T, Jayme A, Ershov A, Faragó T, Pichler O, Tan Jerome N, Aadepu N, Bremer S, Chilingaryan SA, Heethoff M, Kopmann A, Odar J, Schmelzle S, Zuber M, Wittbrodt J, Baumbach T, Heuveline V.

Introducing Biomedisa as an open-source online platform for biomedical image segmentation

Nat Commun

2020

Bosze B, Ono Y, Mattes B, Sinner C, Gourain V, Thumberger T, Tlili S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S.

Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish

Histochem Cell Biol

2020

Gierten J, Pylatiuk C, Hammouda OT, Schock C, Stegmaier J, Wittbrodt J, Gehrig J, Loosli F.

Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions

Sci Rep

2020

Wagner N, Norlin N, Gierten J, de Medeiros G, Balázs B, Wittbrodt J, Hufnagel L, Prevedel R.

Instantaneous isotropic volumetric imaging of fast biological processes

Nat Methods

2019

Hammouda OT, Böttger F, Wittbrodt J, Thumberger T.

Swift Large-scale Examination of Directed Genome Editing

PLoS One

2019

Tsingos E, Höckendorf B, Sütterlin T, Kirchmaier S, Grabe N, Centanin L, Wittbrodt J.

Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

Elife

2019

Lischik CQ, Adelmann L, Wittbrodt J.

Enhanced in vivo-imaging in medaka by optimized anaesthesia, fluorescent protein selection and removal of pigmentation

PLoS One

2019

Vázquez-Marín J, Gutiérrez-Triana JA, Almuedo-Castillo M, Buono L, Gómez-Skarmeta JL, Mateo JL, Wittbrodt J, Martínez-Morales JR.

yap1b, a divergent Yap/Taz family member, cooperates with yap1 in survival and morphogenesis via common transcriptional targets

Development

2019

Kikuchi M, Nishimura T, Saito D, Shigenobu S, Takada R, Gutierrez-Triana JA, Cerdán JLM, Takada S, Wittbrodt J, Suyama M, Tanaka M.

Novel components of germline sex determination acting downstream of foxl3 in medaka

Dev Biol

2019

Eckert P, Knickmeyer MD, Schütz L, Wittbrodt J, Heermann S.

Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt

Open Biol

2019

Dasyani M, Tan WH, Sundaram S, Imangali N, Centanin L, Wittbrodt J, Winkler C.

Lineage tracing of col10a1 cells identifies distinct progenitor populations for osteoblasts and joint cells in the regenerating fin of medaka (Oryzias latipes)

Dev Biol

2019

Gutierrez-Triana JA, Tavhelidse T, Thumberger T, Thomas I, Wittbrodt B, Kellner T, Anlas K, Tsingos E, Wittbrodt J.

Efficient single-copy HDR by 5' modified long dsDNA donors

Elife

2018

Lust K, Wittbrodt J.

Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina

Elife

2018

Pérez Saturnino A, Lust K, Wittbrodt J.

Notch signalling patterns retinal composition by regulating atoh7 during post-embryonic growth

Development

2018

Weinhardt V, Shkarin R, Wernet T, Wittbrodt J, Baumbach T, Loosli F.

Quantitative morphometric analysis of adult teleost fish by X-ray computed tomography

Sci Rep

2018

Knickmeyer MD, Mateo JL, Eckert P, Roussa E, Rahhal B, Zuniga A, Krieglstein K, Wittbrodt J, Heermann S.

TGF?-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism

Open Biol

2018

Inoue D, Wittbrodt J, Gruss OJ.

Loss and Rebirth of the Animal Microtubule Organizing Center: How Maternal Expression of Centrosomal Proteins Cooperates with the Sperm Centriole in Zygotic Centrosome Reformation

Bioessays

2018

Roussigné M, Wei L, Tsingos E, Kuchling F, Alkobtawi M, Tsalavouta M, Wittbrodt J, Carl M, Blader P, Wilson SW.

Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells

Proc Natl Acad Sci U S A

2018

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T.

Bifacial stem cell niches in fish and plants

Curr Opin Genet Dev

2017

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M.

Dynamics of in vivo ASC speck formation

J Cell Biol

2017

Kirchmaier S, Lust K, Wittbrodt J.

Generation of DNA Constructs Using the Golden GATEway Cloning Method

Methods Mol Biol

2017

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M.

Correction: Dynamics of in vivo ASC speck formation

J Cell Biol

2017

Inoue D, Stemmer M, Thumberger T, Ruppert T, Bärenz F, Wittbrodt J, Gruss OJ.

Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses

Nat Commun

2017

Pereiro L, Loosli F, Fernández J, Härtel S, Wittbrodt J, Concha ML.

Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias

Dev Dyn

2017

Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL.

Correction: CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

PLoS One

2017

Mateo JL, van den Berg DLC, Haeussler M, Drechsel D, Gaber ZB, Castro DS, Robson P, Lu QR, Crawford GE, Flicek P, Ettwiller L, Wittbrodt J, Guillemot F, Martynoga B.

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

Genome Res

2017

Gutierrez-Triana JA, Mateo JL, Ibberson D, Ryu S, Wittbrodt J.

iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins

Development

2016

Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J.

Identification, visualization and clonal analysis of intestinal stem cells in fish

Development

2016

Nicolás-Pérez M, Kuchling F, Letelier J, Polvillo R, Wittbrodt J, Martínez-Morales JR.

Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

Elife

2016

Mateo JL, van den Berg DL, Haeussler M, Drechsel D, Gaber ZB, Castro DS, Robson P, Lu QR, Crawford GE, Flicek P, Ettwiller L, Wittbrodt J, Guillemot F, Martynoga B.

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

Genome Res

2016