Stellenangebote am COS Heidelberg
Anfragen bzgl. Master- und Bachelorarbeiten richten Sie bitte direkt an die betreffenden Betreuer oder Arbeitsgruppenleiter, wenn nicht anders angegeben.
Ausbildungsstellen
Das COS bildet Fachinformatiker (m/w), Fachrichtung Systemintegration und Gärtner (m/w) Fachrichtung Zierpflanzenbau aus. (Näheres... 
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Abteilung Arendt
Prof. Detlev Arendt
Abteilung Frings
Prof. Stephan Frings
Dr. Frank Möhrlen
Abteilung Greb
PhD student position
Starting date: January 2019
Radial growth of plant shoots and roots is based on the activity of a group of stem cells, the cambium, and essential for generating large plant bodies. Thereby, it substantially contributes to the dominance of seed plants in terrestrial ecosystems, to wood formation and thus to carbon immobilization. In addition, the process represents a striking example for a constant remodelling of adult body structures and for stem cell regulation. Thus, lateral growth provides excellent opportunities for addressing the fundamental question of how cellular properties are integrated and adapted during the growth of adult organisms. Depending on the interest of the student, we offer the opportunity to investigate cell fate regulation in the context of cambium activity with a molecular, biochemical, evolutionary or computational angle.
more information: HBIGS graduate school or contact Thomas Greb directly.
Prof.Thomas Greb
Abteilung Guse
Prof. Annika Guse
Abteilung Hell
Post doc (TV-L E13, 100%)
and a
PhD student (TV-L E13, 60%)
Starting date: Autumn 2018
The project: The project addresses a fundamental and pivotal question of plant research: How are protein translation, meristem activity and autophagy regulated under nutrient deficiency to achieve optimal growth responses?
A unique feature of our research team is the combined expertise on the regulation of diverse nutrient assimilation pathways, gene expression and metabolomics profiling and the stress-induced regulation of the sensor kinase ’Target of Rapamycin’ (TOR). TOR is one of the central growth regulators in higher eukaryotes. We selected sulfur metabolism as a proxy for nutrient-deficiency based signaling, since reduced sulfur is incorporated into the amino acid cysteine. The linear and relatively simple sulfate assimilation pathway is well characterized in Arabidopsis and genetic resources are available to our research team for all steps of sulfur translocation, reduction and incorporation. The results will be used as a blueprint to understand the basic principles of TOR regulation in response to other nutrients like carbon, nitrogen and phosphorous. This will be highly relevant to engineer nutrient use efficiency in crop plants, since control of translation and stem cell activity in response to nutrient limitations is the key trigger for developmental plasticity-based stress responses.
Relevant literature: Pfeiffer et al. (2016) eLife; Dong et al. (2017) Nat. Comm.
Collaboration Partners: The project offers stimulating interactions and training opportunities within the framework of the Heidelberg Biosciences International Graduate School and all groups at COS. Strong connections to research groups in France (University of Strassbourg) and China (University of Technology and Sciences, Hefei) support the project.
Profile of candidate’s qualifications: We look for highly motivated young scientists with interest in molecular genetics and processes of cellular regulation. Practical experience in molecular biology, biochemistry or cell biology will be of benefit. The applicants should hold a M.Sc. or PhD in Biology, Biochemistry or other relevant subjects. Successful acceptance at the Heidelberg Biosciences International Graduate School is expected for the PhD student.
The University of Heidelberg is an equal opportunity employer.
Please contact Prof. Dr. Ruediger Hell (ruediger.hell@cos.uni-heidelberg.de) or Dr. Markus Wirtz (markus.wirtz@cos.uni-heidelberg.de) for further information and application.
Abteilung Holstein
Prof. Thomas Holstein
Dr. Suat Özbek
Abteilung Koch
Beschreibungen der momentan in der Abteilung Biodiversität und Pflanzensystematik zu vergebenden Stellen finden Sie hier.
Bitte wenden Sie sich mit Anfragen direkt an Prof. Marcus Koch oder Prof. Claudia Erbar.
Abteilung Kummer
Prof. Ursula Kummer
Abteilung Ingrid Lohmann
The Developmental Biology Group (Prof. I. Lohmann) at the Centre for Organismal Studies (COS) in Heidelberg, Germany is looking for
POSTDOC AND/OR PHD STUDENT
to study stem cell behaviour in the Drosophila testis.
The Lohmann lab (http://ilohmann-lab.org) works on elucidating the role of HOX transcription factors in defining cell fate using Drosophila as a model. We are located at the Centre for Organismal Studies (COS) at the University of Heidelberg, Germany and part of the collaborative research network SFB873 “Maintenance and Differentiation of Stem Cells in Development and Disease” (https://www.cos.uni- heidelberg.de/index.php/sfb873?l=_e).
We now seek for enthusiastic new colleagues to analyze the interplay between germline stem cells and their support cells under homeostatic and compromised cellular conditions. In particular, the project aims at identifying pathways monitoring genome integrity in stem cells and at uncovering the role of mitotic checkpoint components in monitoring asymmetric stem cell division in the male germline. The project builds on a wide array of advanced resources established in the Lohmann lab and will provide ample opportunity to implement and apply high-end techniques to investigate stem cells of the Drosophila male stem cell system at multiple scales.
The Heidelberg Molecular Life Science Community offers a vibrant stem cell research community, as well as state-of-the-art core facilities. You will have the opportunity to closely collaborate with highly recognized stem cell researchers of the SFB873 and beyond.
Successful candidates will have experience in confocal microscopy, advanced immunohistochemistry and possibly in Drosophila genetics and molecular biology. The ability to quickly integrate into an interdisciplinary team and work independently within an academic research environment is essential. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.
Applications should be sent to:
Prof. Dr. Ingrid Lohmann
Centre for Organismal Studies (COS) Heidelberg Im Neuenheimer Feld 267
D- 69120 Heidelberg, Germany ingrid.lohmann@cos.uni-heidelberg.de http://ilohmann-lab.org
Project-related publications:
1. Papagiannouli F, Schardt L, Grajcarek J, Ha N and Lohmann I (2014). The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Developmental Cell 28, 189-202.
2. Merabet S and Lohmann I (2015). Towards a new twist in Hox and TALE DNA- binding specificity. Developmental Cell 32(3):259-261.
3. Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU and Lohmann I (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Reports 24(11):3072-3086.
4. Trost N, Rempel E, Ermakove O, Tamirisa S, Parcalabescu, Boutros M, Lohmann JU and Lohmann I (2018). WEADE: A workflow for enrichment analysis and data exploration. PLoS One 13(9):e0204016.
Prof. Ingrid Lohmann
Abteilung Jan Lohmann
A PhD or Post-Doc position in “Cell wall signalling-mediated control of plant cell identity“, to be filled immediately, is available in the J. Lohmann and S. Wolf labs at the Centre of Organismal Studies (COS) Heidelberg.
Project Title: Cell wall signalling-mediated control of plant cell identity
Project Description:
How the development of complex multicellular organisms is accomplished through coordinated cell proliferation, differentiation, and growth is a fundamental biological question. The rigid, yet dynamic plant cell wall, is known to guide morphogenesis through selective restriction of cell expansion and is under constant surveillance by cell surface receptors connected to intracellular signalling. However, very little is known about how this cell wall-mediated feedback signalling intersects with the regulatory mechanisms of plant development. Using state-of-the-art genetic tools, life cell imaging, and scRNA-seq analysis, we aim to unravel how cues from the cell wall affect transcriptomic signatures and cellular behaviour. With thereby seek to decipher the role of cell wall signalling in the control of cell fate trajectories and to understand how extracellular cues are integrated with intracellular growth-regulatory networks in the in the shoot apical meristem, which harbours the stem cell niche generating most of the above-ground plant organs.
COS offers a vibrant research environment with a collegial atmosphere and access to a wide range of facilities. We are looking for a highly motivated individual interested in working with plants using state-of-the-art molecular biology and cell biology methods. Applicants should hold a degree in biology, biochemistry, biotechnology, or a related field. The project is carried out in association with the DFG research unit FOR2581 “Quantitative Morphodynamics of Plants”.
The University of Heidelberg is an equal opportunity employer.
Please contact Jan Lohman (jan.lohmann@cos.uni-heidelberg.de) and Sebastian Wolf (sebastian.wolf@cos.uni-heidelberg.de) for further information and application.
Relevant Publications:
Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Li L, Pfeiffer A, Miotk A, Hakenjos JP, Forner J, Yanofsky MF, Marciniak-Czochra A, Lohmann JU (2017). Control of plant cell fate transitions by transcriptional and hormonal signals. Elife. doi: 10.7554/eLife.30135.
Holzwart E, Huerta AI, Gloeckner N, Garnelo Gomez B, Ladwig F, Augustin S, Askani JC,Schuerholz A-K, Harter K, Wolf S (2018) Integration of Brassinosteroid and Phytosulfokine Signalling Controls Vascular Cell Fate in the Arabidopsis Root. bioRxiv
Schürholz A-K, López-Salmerón V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Lohmann JU, Greb T, Wolf S (2018) A comprehensive toolkit for inducible, cell type-specific gene expression in Arabidopsis. Plant Physiology doi:10.1104/pp.18.00463
Webpages:
https://www.cos.uni-heidelberg.de/index.php/j.lohmann?l=_e
https://www.cos.uni-heidelberg.de/index.php/index.php/s.wolf?l=_e
Prof. Jan Lohmann
Abteilung Maizel
Prof. Alexis Maizel
Abteilung Pereira
Dr. Gislene Pereira
Abteilung Pollerberg
The “Developmental Neurobiology” group, member of the Center for Organismal Studies (COS) and the Interdisciplinary Center for Neurosciences (IZN), is looking for a highly motivated
Postdoc (f/m)
We are interested in the molecular basis of axon growth during development and regeneration. The Postdoc-project will focus on the interactions of cell adhesion molecules with other types of proteins and the impact of these interactions on axon elongation and navigation. Substantial amounts of data have already been collected for several projects; the Postdoc is therefore expected to complete and publish these studies. In addition to these basic research projects, also a new translational project could be started aiming at the improvement of axon regeneration. We are looking for a self-motivated person with a background in molecular and cellular biology, ideally in neurosciences.
We are a small but well equipped group with access to all facilities on the campus. The position is available (for up to 3 years) from 1st of April on (also a later start is possible); please send your applications until 10th of March. Payment will be according to German TV-L13 (full time; can be split). Please send your CV, relevant certificates, and a short letter of motivation (all documents as one pdf file) to G.E.Pollerberg@cos.uni-heidelberg. Preference will be given to equally qualified applicants with severe disabilities. For further inquiries, please do not hesitate to contact Elisabeth Pollerberg.
Prof. G.E. Pollerberg
Abteilung Rausch
Prof. Thomas Rausch
Dr. Steffen Greiner
Abteilung Schumacher
Prof. Karin Schumacher
Abteilung Strahl
Prof. Sabine Strahl
Abteilung Wittbrodt
Alle Doktorarbeiten in der Abteilung Wittbrodt werden über HBIGS gehandhabt.
Anfragen auf Bachelor-, Master- oder PostDoc-Ebene richten Sie bitte an Jochen Wittbrodt.
Anfragen in der AG Braunbeck richten Sie bitte direkt an den Arbeitsgruppenleiter.
Unabhängige Nachwuchsgruppen
Dr. Sergio Acebrón
Dr. Lazaro Centanin
Dr. Jan-Felix Evers
Dr. Emmanuel Gaquerel
Dr. Guido Grossmann
Juniorprof. Dr. Steffen Lemke
Dr. Michael Raissig
Dr. Sebastian Wolf
A PhD or Post-Doc position in “Cell wall signalling-mediated control of plant cell identity“, to be filled immediately, is available in the J. Lohmann and S. Wolf labs at the Centre of Organismal Studies (COS) Heidelberg.
Project Title: Cell wall signalling-mediated control of plant cell identity
Project Description:
How the development of complex multicellular organisms is accomplished through coordinated cell proliferation, differentiation, and growth is a fundamental biological question. The rigid, yet dynamic plant cell wall, is known to guide morphogenesis through selective restriction of cell expansion and is under constant surveillance by cell surface receptors connected to intracellular signalling. However, very little is known about how this cell wall-mediated feedback signalling intersects with the regulatory mechanisms of plant development. Using state-of-the-art genetic tools, life cell imaging, and scRNA-seq analysis, we aim to unravel how cues from the cell wall affect transcriptomic signatures and cellular behaviour. With thereby seek to decipher the role of cell wall signalling in the control of cell fate trajectories and to understand how extracellular cues are integrated with intracellular growth-regulatory networks in the in the shoot apical meristem, which harbours the stem cell niche generating most of the above-ground plant organs.
COS offers a vibrant research environment with a collegial atmosphere and access to a wide range of facilities. We are looking for a highly motivated individual interested in working with plants using state-of-the-art molecular biology and cell biology methods. Applicants should hold a degree in biology, biochemistry, biotechnology, or a related field. The project is carried out in association with the DFG research unit FOR2581 “Quantitative Morphodynamics of Plants”.
The University of Heidelberg is an equal opportunity employer.
Please contact Jan Lohman (jan.lohmann@cos.uni-heidelberg.de) and Sebastian Wolf (sebastian.wolf@cos.uni-heidelberg.de) for further information and application.
Relevant Publications:
Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Li L, Pfeiffer A, Miotk A, Hakenjos JP, Forner J, Yanofsky MF, Marciniak-Czochra A, Lohmann JU (2017). Control of plant cell fate transitions by transcriptional and hormonal signals. Elife. doi: 10.7554/eLife.30135.
Holzwart E, Huerta AI, Gloeckner N, Garnelo Gomez B, Ladwig F, Augustin S, Askani JC,Schuerholz A-K, Harter K, Wolf S (2018) Integration of Brassinosteroid and Phytosulfokine Signalling Controls Vascular Cell Fate in the Arabidopsis Root. bioRxiv
Schürholz A-K, López-Salmerón V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Lohmann JU, Greb T, Wolf S (2018) A comprehensive toolkit for inducible, cell type-specific gene expression in Arabidopsis. Plant Physiology doi:10.1104/pp.18.00463
Webpages:
https://www.cos.uni-heidelberg.de/index.php/j.lohmann?l=_e
https://www.cos.uni-heidelberg.de/index.php/index.php/s.wolf?l=_e
Metabolomics Core Technology Platform
Anfragen bitte an Dr. Markus Wirtz
BBW-ForWerts
Prof.Thomas Rausch