Stellenangebote am COS Heidelberg
Anfragen bzgl. Master- und Bachelorarbeiten richten Sie bitte direkt an die betreffenden Betreuer oder Arbeitsgruppenleiter, wenn nicht anders angegeben.
Ausbildungsstellen
Das COS bildet Fachinformatiker (m/w), Fachrichtung Systemintegration und Gärtner (m/w) Fachrichtung Zierpflanzenbau aus. (Näheres... 
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Abteilung Arendt
Prof. Detlev Arendt
Abteilung Frings
Prof. Stephan Frings
Dr. Frank Möhrlen
Abteilung Greb
Prof.Thomas Greb
Abteilung Guse
Prof. Annika Guse
Abteilung Hell
Am Centre for Organismal Studies der Universität Heidelberg ist zum 01.12.2019/01.01.2020 die folgende Stelle zu besetzen:
Wissenschaftliche/wissenschaftlicher Mitarbeiterin/Mitarbeiter (w/m/d) der Metabolomics Core Technology Platform
- Vollzeit -
Die Metabolomics Core Technology Platform wird von der Exzellenzstrategie der Universität Heidelberg, sowie dem Deutschen Krebsforschungszentrum Heidelberg unterstützt und ist im interdisziplinären Centre for Organismal Studies (COS) Heidelberg angesiedelt.
Ihre Aufgaben
- Durchführung und Unterstützung in der Planung von Forschungsprojekten im Bereich Bioanalytik kleiner Moleküle in enger Kooperation mit Forschungsgruppen des Deutschen Krebsforschungszentrums und Einrichtungen der Universität Heidelberg
- Entwicklung und Optimierung neuer GC-MS / LC-MS-Methoden zur sensitiven Bestimmung von Metaboliten aus verschiedensten biologischen Matrices
- Evaluierung und Etablierung von Datenanalyseprogrammen zur Auswertung von MS-Datensätzen von Isotopen-Markierungsexperimenten („13C-Tracing“)
Ihr Qualifikationsprofil
- Eine abgeschlossene Promotion im Bereich Biologie, Chemie, Biochemie, Pharmazie oder einer vergleichbaren naturwissenschaftlichen Fachrichtung
- Erfahrung und fundierte Kenntnisse auf dem Gebiet der Massenspektrometrie und Chromatographie incl. Probenvorbereitung
- Freude an ergebnisorientierter Arbeit im Team
- Sehr gute deutsche und englische Sprachkenntnisse in Wort und Schrift
- Exzellente Kommunikationsfähigkeiten und soziale Kompetenz
- Erfahrung im serviceorientierten Arbeitsumfeld von Vorteil
Wir bieten
- Gut ausgestattete Forschungslabore
- Ein innovatives Arbeitsumfeld und kollegiale Zusammenarbeit
- Interessante und abwechslungsreiche Projekte
- Unterstützung bei Weiterbildung und Zusatzqualifikation
Die Vergütung erfolgt nach TV-L E13.
Die Stelle ist befristet bis zum 30.11.2024 und grundsätzlich teilbar. Die Möglichkeit einer Weiterbeschäftigung/Verlängerung besteht.
Schriftliche Bewerbungen mit Lebenslauf, Lichtbild und Zeugnissen senden Sie bitte bis spätestens 31. Oktober 2019 an das Sekretariat des Centre for Organismal Studies per Email in einem einzigen PDF-Dokument: sekretariat360@cos.uni-heidelberg.de
Schwerbehinderte werden bei gleicher Eignung vorrangig eingestellt.
The University of Heidelberg offers the positions of a
PhD student (TV-L E13, 60%).
Location: Centre for Organismal Studies (COS) Starting date: Autumn/Winter 2019
Project: The proposed project is designed to address a fundamental question of plant research: How is co-translational imprinting of the proteome affecting proteostasis and protein translation under diverse abiotic stresses to achieve acclimative growth responses?
N-terminal protein acetylation occurs at the ribosome of eukaryotes and affects more than 80% of cytosolic proteins in humans and plants. Despite the prevalence of this imprinting mechanism on the plant proteome, we know only little about its contribution to protein function.
We recently demonstrated that N-terminal protein acetylation is dynamically regulated by the stress-hormone abscisic acid, which decreases transcription and stability of the ribosome-associated N-terminal acetyltransferase complex A (NatA). Down-regulation of NatA activity in genetically engineered plants causes sensitivity towards abiotic and biotic stresses and constitutively activates the abscisic acid response 1, 2.
This project aims to elucidate the function of N-terminal protein acetylation for stress-induced regulation of protein turnover. A unique feature of our research team is the combined expertise on profiling of stress-induced translation, co-translational modifications of proteins, and protein stability. We will apply this expertise to unravel how abscisic acid affects proteasome-dependent destruction of NatA substrates. Furthermore, we will test the importance of candidate E3 ubiquitin ligases for specific recognition of N-terminally acetylated proteins (N-degrons).
Collaboration Partners: The project offers stimulating interactions and training opportunities within the framework of the Heidelberg Biosciences International Graduate School and all groups at COS. Strong connections to research groups in France (CNRS/University of Paris-Saclay) and United Kingdom (University of Birmingham) support the project.
Profile of candidate’s qualifications: We look for highly motivated young scientists with interest in molecular genetics and cellular regulation. Practical experience in molecular biology, biochemistry or cell biology of plants will be of benefit. The applicants should hold a M.Sc. in Biology, Biochemistry or other relevant subjects. Successful acceptance at the Heidelberg Biosciences International Graduate School is expected for the PhD student.
The University of Heidelberg is an equal opportunity employer.
Profile of the host lab: The project is offered by the department of Plant Molecular Biology (www.cos.uni-heidelberg.de), which has a long-standing record to successfully graduated PhD students and a leading expertise in co-translation modification of proteins and the stress-induced regulation of translation in plants.
Please send your full application as a PDF file to sekretariat360@cos.uni-heidelberg.de
1. Linster E, et al. Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat Commun 6, 7640 (2015).
2. Xu F, et al. Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Plant Cell 27, 1547-1562 (2015).
Abteilung Holstein
Prof. Thomas Holstein
Dr. Suat Özbek
Abteilung Koch
Beschreibungen der momentan in der Abteilung Biodiversität und Pflanzensystematik zu vergebenden Stellen finden Sie hier.
Bitte wenden Sie sich mit Anfragen direkt an Prof. Marcus Koch oder Prof. Claudia Erbar.
Abteilung Kummer
Prof. Ursula Kummer
Abteilung Ingrid Lohmann
The Developmental Biology Group (Prof. I. Lohmann) at the Centre for Organismal Studies (COS) in Heidelberg, Germany is looking for
POSTDOC AND/OR PHD STUDENT
to study stem cell behaviour in the Drosophila testis.
The Lohmann lab (http://ilohmann-lab.org) works on elucidating the role of HOX transcription factors in defining cell fate using Drosophila as a model. We are located at the Centre for Organismal Studies (COS) at the University of Heidelberg, Germany and part of the collaborative research network SFB873 “Maintenance and Differentiation of Stem Cells in Development and Disease” (https://www.cos.uni- heidelberg.de/index.php/sfb873?l=_e).
We now seek for enthusiastic new colleagues to analyze the interplay between germline stem cells and their support cells under homeostatic and compromised cellular conditions. In particular, the project aims at identifying pathways monitoring genome integrity in stem cells and at uncovering the role of mitotic checkpoint components in monitoring asymmetric stem cell division in the male germline. The project builds on a wide array of advanced resources established in the Lohmann lab and will provide ample opportunity to implement and apply high-end techniques to investigate stem cells of the Drosophila male stem cell system at multiple scales.
The Heidelberg Molecular Life Science Community offers a vibrant stem cell research community, as well as state-of-the-art core facilities. You will have the opportunity to closely collaborate with highly recognized stem cell researchers of the SFB873 and beyond.
Successful candidates will have experience in confocal microscopy, advanced immunohistochemistry and possibly in Drosophila genetics and molecular biology. The ability to quickly integrate into an interdisciplinary team and work independently within an academic research environment is essential. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.
Applications should be sent to:
Prof. Dr. Ingrid Lohmann
Centre for Organismal Studies (COS) Heidelberg Im Neuenheimer Feld 267
D- 69120 Heidelberg, Germany ingrid.lohmann@cos.uni-heidelberg.de http://ilohmann-lab.org
Project-related publications:
1. Papagiannouli F, Schardt L, Grajcarek J, Ha N and Lohmann I (2014). The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Developmental Cell 28, 189-202.
2. Merabet S and Lohmann I (2015). Towards a new twist in Hox and TALE DNA- binding specificity. Developmental Cell 32(3):259-261.
3. Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU and Lohmann I (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Reports 24(11):3072-3086.
4. Trost N, Rempel E, Ermakove O, Tamirisa S, Parcalabescu, Boutros M, Lohmann JU and Lohmann I (2018). WEADE: A workflow for enrichment analysis and data exploration. PLoS One 13(9):e0204016.
Prof. Ingrid Lohmann
Abteilung Jan Lohmann
A PhD or Post-Doc position in “Cell wall signalling-mediated control of plant cell identity“, to be filled immediately, is available in the J. Lohmann and S. Wolf labs at the Centre of Organismal Studies (COS) Heidelberg.
Project Title: Cell wall signalling-mediated control of plant cell identity
Project Description:
How the development of complex multicellular organisms is accomplished through coordinated cell proliferation, differentiation, and growth is a fundamental biological question. The rigid, yet dynamic plant cell wall, is known to guide morphogenesis through selective restriction of cell expansion and is under constant surveillance by cell surface receptors connected to intracellular signalling. However, very little is known about how this cell wall-mediated feedback signalling intersects with the regulatory mechanisms of plant development. Using state-of-the-art genetic tools, life cell imaging, and scRNA-seq analysis, we aim to unravel how cues from the cell wall affect transcriptomic signatures and cellular behaviour. With thereby seek to decipher the role of cell wall signalling in the control of cell fate trajectories and to understand how extracellular cues are integrated with intracellular growth-regulatory networks in the in the shoot apical meristem, which harbours the stem cell niche generating most of the above-ground plant organs.
COS offers a vibrant research environment with a collegial atmosphere and access to a wide range of facilities. We are looking for a highly motivated individual interested in working with plants using state-of-the-art molecular biology and cell biology methods. Applicants should hold a degree in biology, biochemistry, biotechnology, or a related field. The project is carried out in association with the DFG research unit FOR2581 “Quantitative Morphodynamics of Plants”.
The University of Heidelberg is an equal opportunity employer.
Please contact Jan Lohman (jan.lohmann@cos.uni-heidelberg.de) and Sebastian Wolf (sebastian.wolf@cos.uni-heidelberg.de) for further information and application.
Relevant Publications:
Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Li L, Pfeiffer A, Miotk A, Hakenjos JP, Forner J, Yanofsky MF, Marciniak-Czochra A, Lohmann JU (2017). Control of plant cell fate transitions by transcriptional and hormonal signals. Elife. doi: 10.7554/eLife.30135.
Holzwart E, Huerta AI, Gloeckner N, Garnelo Gomez B, Ladwig F, Augustin S, Askani JC,Schuerholz A-K, Harter K, Wolf S (2018) Integration of Brassinosteroid and Phytosulfokine Signalling Controls Vascular Cell Fate in the Arabidopsis Root. bioRxiv
Schürholz A-K, López-Salmerón V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Lohmann JU, Greb T, Wolf S (2018) A comprehensive toolkit for inducible, cell type-specific gene expression in Arabidopsis. Plant Physiology doi:10.1104/pp.18.00463
Webpages:
https://www.cos.uni-heidelberg.de/index.php/j.lohmann?l=_e
https://www.cos.uni-heidelberg.de/index.php/s.wolf?l=_e
Prof. Jan Lohmann
Abteilung Maizel
Prof. Alexis Maizel
Abteilung Pereira
Dr. Gislene Pereira
Abteilung Pollerberg
Prof. G.E. Pollerberg
Abteilung Rausch
Prof. Thomas Rausch
Dr. Steffen Greiner
Abteilung Schumacher
Prof. Karin Schumacher
Abteilung Strahl
Prof. Sabine Strahl
Abteilung Wittbrodt
Alle Doktorarbeiten in der Abteilung Wittbrodt werden über HBIGS gehandhabt.
Anfragen auf Bachelor-, Master- oder PostDoc-Ebene richten Sie bitte an Jochen Wittbrodt.
Anfragen in der AG Braunbeck richten Sie bitte direkt an den Arbeitsgruppenleiter.
Unabhängige Nachwuchsgruppen
Dr. Sergio Acebrón
Dr. Lazaro Centanin
Dr. Jan-Felix Evers
Dr. Emmanuel Gaquerel
Dr. Guido Grossmann
Juniorprof. Dr. Steffen Lemke
Dr. Michael Raissig
Dr. Sebastian Wolf
A PhD or Post-Doc position in “Cell wall signalling-mediated control of plant cell identity“, to be filled immediately, is available in the J. Lohmann and S. Wolf labs at the Centre of Organismal Studies (COS) Heidelberg.
Project Title: Cell wall signalling-mediated control of plant cell identity
Project Description:
How the development of complex multicellular organisms is accomplished through coordinated cell proliferation, differentiation, and growth is a fundamental biological question. The rigid, yet dynamic plant cell wall, is known to guide morphogenesis through selective restriction of cell expansion and is under constant surveillance by cell surface receptors connected to intracellular signalling. However, very little is known about how this cell wall-mediated feedback signalling intersects with the regulatory mechanisms of plant development. Using state-of-the-art genetic tools, life cell imaging, and scRNA-seq analysis, we aim to unravel how cues from the cell wall affect transcriptomic signatures and cellular behaviour. With thereby seek to decipher the role of cell wall signalling in the control of cell fate trajectories and to understand how extracellular cues are integrated with intracellular growth-regulatory networks in the in the shoot apical meristem, which harbours the stem cell niche generating most of the above-ground plant organs.
COS offers a vibrant research environment with a collegial atmosphere and access to a wide range of facilities. We are looking for a highly motivated individual interested in working with plants using state-of-the-art molecular biology and cell biology methods. Applicants should hold a degree in biology, biochemistry, biotechnology, or a related field. The project is carried out in association with the DFG research unit FOR2581 “Quantitative Morphodynamics of Plants”.
The University of Heidelberg is an equal opportunity employer.
Please contact Jan Lohman (jan.lohmann@cos.uni-heidelberg.de) and Sebastian Wolf (sebastian.wolf@cos.uni-heidelberg.de) for further information and application.
Relevant Publications:
Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Li L, Pfeiffer A, Miotk A, Hakenjos JP, Forner J, Yanofsky MF, Marciniak-Czochra A, Lohmann JU (2017). Control of plant cell fate transitions by transcriptional and hormonal signals. Elife. doi: 10.7554/eLife.30135.
Holzwart E, Huerta AI, Gloeckner N, Garnelo Gomez B, Ladwig F, Augustin S, Askani JC,Schuerholz A-K, Harter K, Wolf S (2018) Integration of Brassinosteroid and Phytosulfokine Signalling Controls Vascular Cell Fate in the Arabidopsis Root. bioRxiv
Schürholz A-K, López-Salmerón V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Lohmann JU, Greb T, Wolf S (2018) A comprehensive toolkit for inducible, cell type-specific gene expression in Arabidopsis. Plant Physiology doi:10.1104/pp.18.00463
Webpages:
https://www.cos.uni-heidelberg.de/index.php/j.lohmann?l=_e
https://www.cos.uni-heidelberg.de/index.php/s.wolf?l=_e
Metabolomics Core Technology Platform
Anfragen bitte an Dr. Markus Wirtz
BBW-ForWerts
Prof.Thomas Rausch