Job Opportunities at COS Heidelberg
For Master and Bachelor theses, please contact the respective supervisor directly if not stated differently.
Apprenticeship positions are available at COS for "Fachinformatiker (m/w) Fachrichtung Systemintegration" and "Gärtner (m/w) Fachrichtung Zierpflanzenbau". More...
Prof. Detlev Arendt
Prof. Stephan Frings
Dr. Frank Möhrlen
PhD student position
Starting date: January 2019
Radial growth of plant shoots and roots is based on the activity of a group of stem cells, the cambium, and essential for generating large plant bodies. Thereby, it substantially contributes to the dominance of seed plants in terrestrial ecosystems, to wood formation and thus to carbon immobilization. In addition, the process represents a striking example for a constant remodelling of adult body structures and for stem cell regulation. Thus, lateral growth provides excellent opportunities for addressing the fundamental question of how cellular properties are integrated and adapted during the growth of adult organisms. Depending on the interest of the student, we offer the opportunity to investigate cell fate regulation in the context of cambium activity with a molecular, biochemical, evolutionary or computational angle.
more information: HBIGS graduate school or contact Thomas Greb directly.
Post doc (TV-L E13, 100%)
PhD student (TV-L E13, 60%)
Starting date: Autumn 2018
The project: The project addresses a fundamental and pivotal question of plant research: How are protein translation, meristem activity and autophagy regulated under nutrient deficiency to achieve optimal growth responses?
A unique feature of our research team is the combined expertise on the regulation of diverse nutrient assimilation pathways, gene expression and metabolomics profiling and the stress-induced regulation of the sensor kinase ’Target of Rapamycin’ (TOR). TOR is one of the central growth regulators in higher eukaryotes. We selected sulfur metabolism as a proxy for nutrient-deficiency based signaling, since reduced sulfur is incorporated into the amino acid cysteine. The linear and relatively simple sulfate assimilation pathway is well characterized in Arabidopsis and genetic resources are available to our research team for all steps of sulfur translocation, reduction and incorporation. The results will be used as a blueprint to understand the basic principles of TOR regulation in response to other nutrients like carbon, nitrogen and phosphorous. This will be highly relevant to engineer nutrient use efficiency in crop plants, since control of translation and stem cell activity in response to nutrient limitations is the key trigger for developmental plasticity-based stress responses.
Relevant literature: Pfeiffer et al. (2016) eLife; Dong et al. (2017) Nat. Comm.
Collaboration Partners: The project offers stimulating interactions and training opportunities within the framework of the Heidelberg Biosciences International Graduate School and all groups at COS. Strong connections to research groups in France (University of Strassbourg) and China (University of Technology and Sciences, Hefei) support the project.
Profile of candidate’s qualifications: We look for highly motivated young scientists with interest in molecular genetics and processes of cellular regulation. Practical experience in molecular biology, biochemistry or cell biology will be of benefit. The applicants should hold a M.Sc. or PhD in Biology, Biochemistry or other relevant subjects. Successful acceptance at the Heidelberg Biosciences International Graduate School is expected for the PhD student.
The University of Heidelberg is an equal opportunity employer.
Prof. Thomas Holstein
Dr. Suat Özbek
Please find descriptions of currently open positions within our department here.
Please contact Prof. Marcus Koch or Prof. Claudia Erbar directly.
Dr. Anja Schmidt accepts applications for internships, Bachelor and Master projects.
Please contact Dr. Anja Schmidt.
Prof. Ursula Kummer
Prof. Ingrid Lohmann
The Developmental Biology Group (Prof. I. Lohmann) at the Centre for Organismal Studies (COS) in Heidelberg, Germany is looking for
POSTDOC AND/OR PHD STUDENT
to study stem cell behaviour in the Drosophila testis.
The Lohmann lab (http://ilohmann-lab.org) works on elucidating the role of HOX transcription factors in defining cell fate using Drosophila as a model. We are located at the Centre for Organismal Studies (COS) at the University of Heidelberg, Germany and part of the collaborative research network SFB873 “Maintenance and Differentiation of Stem Cells in Development and Disease” (https://www.cos.uni- heidelberg.de/index.php/sfb873?l=_e).
We now seek for enthusiastic new colleagues to analyze the interplay between germline stem cells and their support cells under homeostatic and compromised cellular conditions. In particular, the project aims at identifying pathways monitoring genome integrity in stem cells and at uncovering the role of mitotic checkpoint components in monitoring asymmetric stem cell division in the male germline. The project builds on a wide array of advanced resources established in the Lohmann lab and will provide ample opportunity to implement and apply high-end techniques to investigate stem cells of the Drosophila male stem cell system at multiple scales.
The Heidelberg Molecular Life Science Community offers a vibrant stem cell research community, as well as state-of-the-art core facilities. You will have the opportunity to closely collaborate with highly recognized stem cell researchers of the SFB873 and beyond.
Successful candidates will have experience in confocal microscopy, advanced immunohistochemistry and possibly in Drosophila genetics and molecular biology. The ability to quickly integrate into an interdisciplinary team and work independently within an academic research environment is essential. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.
Applications should be sent to:
Prof. Dr. Ingrid Lohmann
Centre for Organismal Studies (COS) Heidelberg Im Neuenheimer Feld 267
D- 69120 Heidelberg, Germany email@example.com http://ilohmann-lab.org
1. Papagiannouli F, Schardt L, Grajcarek J, Ha N and Lohmann I (2014). The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Developmental Cell 28, 189-202.
2. Merabet S and Lohmann I (2015). Towards a new twist in Hox and TALE DNA- binding specificity. Developmental Cell 32(3):259-261.
3. Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU and Lohmann I (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Reports 24(11):3072-3086.
4. Trost N, Rempel E, Ermakove O, Tamirisa S, Parcalabescu, Boutros M, Lohmann JU and Lohmann I (2018). WEADE: A workflow for enrichment analysis and data exploration. PLoS One 13(9):e0204016.
Prof. Jan Lohmann
PhD Position in Developmental Neurobiology
Topic: Molecular mechanisms of axon growth
The project in our department aims at a better understanding of the molecular mechanisms underlying the growth and navigation of axons during development and regeneration. In particular, we study the role of cell adhesion molecules, cytoskeletal components, and intracellular signalling molecules which mediate between them. The project is basic research but aims at contributing to the development of novel therapeutic approaches, e. g. for axon regeneration (patents). Our major model system is the retina of chick and mouse embryo and our approaches comprise a broad spectrum of state-of-the-art techniques such as elaborate cell and tissue culture systems, molecular biology/biochemistry and micro-/nano-technology, and live imaging microscopy. For details, please visit our webpage: Stellen / Open Positions and have a look at our review article http://www.sciencedirect.com/science/article/pii/S092547731200113X .
We offer a well equipped department (Faculty of Biosciences) which is member of the COS (Center for Organismal Studies) and IZN (Interdisciplinary Center for Neurosciences) and also of the Cell Network Excellence Cluster. The Heidelberg Campus provides not only a very stimulating scientific environment but also a wide range of excellent facilities such as the Nikon Imaging Center, electron microscopy core facility, RNAi screening facility, deep sequencing core facility etc.. In our department, we offer supportive mentoring, motivating atmosphere, and safe funding of the PhD projects for 3 years (50% TVL E13). For questions or applications, please send an email to G.E.Pollerberg@cos.uni-heidelberg.de (CV as a single pdf; please note that any documents submitted by mail cannot be returned).
Prof. Thomas Rausch
Dr. Steffen Greiner
Prof. Karin Schumacher
Prof. Sabine Strahl
All PhD students in the Wittbrodt group are recruited through HBIGS
Please contact Dr. Markus Wirtz.