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Job Opportunities at COS Heidelberg

For Master and Bachelor theses, please contact the respective supervisor directly if not stated differently.

 

Apprenticeship positions

Apprenticeship positions are available at COS for "Fachinformatiker (m/w) Fachrichtung Systemintegration" and "Gärtner (m/w) Fachrichtung Zierpflanzenbau". More... 

Arendt group

Prof. Detlev Arendt

Frings group

Prof. Stephan Frings
Dr. Frank Möhrlen

Greb group

Prof. Thomas Greb  

Guse group

Prof. Annika Guse  

Hell group

Am Centre for Organismal Studies der Universität Heidelberg ist zum 01.12.2019/01.01.2020 die folgende Stelle zu besetzen:

Wissenschaftliche/wissenschaftlicher Mitarbeiterin/Mitarbeiter (w/m/d) der Metabolomics Core Technology Platform

  • Vollzeit -

Die Metabolomics Core Technology Platform wird von der Exzellenzstrategie der Universität Heidelberg, sowie dem Deutschen Krebsforschungszentrum Heidelberg unterstützt und ist im interdisziplinären Centre for Organismal Studies (COS) Heidelberg angesiedelt.

Ihre Aufgaben

  • Durchführung und Unterstützung in der Planung von Forschungsprojekten im Bereich Bioanalytik kleiner Moleküle in enger Kooperation mit Forschungsgruppen des Deutschen Krebsforschungszentrums und Einrichtungen der Universität Heidelberg
  • Entwicklung und Optimierung neuer GC-MS / LC-MS-Methoden zur sensitiven Bestimmung von Metaboliten aus verschiedensten biologischen Matrices
  • Evaluierung und Etablierung von Datenanalyseprogrammen zur Auswertung von MS-Datensätzen von Isotopen-Markierungsexperimenten („13C-Tracing“)

Ihr Qualifikationsprofil

  • Eine abgeschlossene Promotion im Bereich Biologie, Chemie, Biochemie, Pharmazie oder einer vergleichbaren naturwissenschaftlichen Fachrichtung
  • Erfahrung und fundierte Kenntnisse auf dem Gebiet der Massenspektrometrie und Chromatographie incl. Probenvorbereitung
  • Freude an ergebnisorientierter Arbeit im Team
  • Sehr gute deutsche und englische Sprachkenntnisse in Wort und Schrift
  • Exzellente Kommunikationsfähigkeiten und soziale Kompetenz
  • Erfahrung im serviceorientierten Arbeitsumfeld von Vorteil

Wir bieten

  • Gut ausgestattete Forschungslabore
  • Ein innovatives Arbeitsumfeld und kollegiale Zusammenarbeit
  • Interessante und abwechslungsreiche Projekte
  • Unterstützung bei Weiterbildung und Zusatzqualifikation

Die Vergütung erfolgt nach TV-L E13.

Die Stelle ist befristet bis zum 30.11.2024 und grundsätzlich teilbar. Die Möglichkeit einer Weiterbeschäftigung/Verlängerung besteht.

Schriftliche Bewerbungen mit Lebenslauf, Lichtbild und Zeugnissen senden Sie bitte bis spätestens 31. Oktober 2019 an das Sekretariat des Centre for Organismal Studies per Email in einem einzigen PDF-Dokument: sekretariat360@cos.uni-heidelberg.de

Schwerbehinderte werden bei gleicher Eignung vorrangig eingestellt. 

 

 

The University of Heidelberg offers the positions of a

 

PhD student (TV-L E13, 60%).

 

Location: Centre for Organismal Studies (COS)                          Starting date: Autumn/winter 2019

 

Project: The proposed project is designed to address a fundamental question of plant research: How is co-translational imprinting of the proteome affecting proteostasis and protein translation under diverse abiotic stresses to achieve acclimative growth responses?

N-terminal protein acetylation occurs at the ribosome of eukaryotes and affects more than 80% of cytosolic proteins in humans and plants. Despite the prevalence of this imprinting mechanism on the plant proteome, we know only little about its contribution to protein function.

We recently demonstrated that N-terminal protein acetylation is dynamically regulated by the stress-hormone abscisic acid, which decreases transcription and stability of the ribosome-associated N-terminal acetyltransferase complex A (NatA). Down-regulation of NatA activity in genetically engineered plants causes sensitivity towards abiotic and biotic stresses and constitutively activates the abscisic acid response 1, 2.

This project aims to elucidate the function of N-terminal protein acetylation for stress-induced regulation of protein turnover. A unique feature of our research team is the combined expertise on profiling of stress-induced translation, co-translational modifications of proteins, and protein stability. We will apply this expertise to unravel how abscisic acid affects proteasome-dependent destruction of NatA substrates. Furthermore, we will test the importance of candidate E3 ubiquitin ligases for specific recognition of N-terminally acetylated proteins (N-degrons).

 

Collaboration Partners: The project offers stimulating interactions and training opportunities within the framework of the Heidelberg Biosciences International Graduate School and all groups at COS. Strong connections to research groups in France (CNRS/University of Paris-Saclay) and United Kingdom (University of Birmingham) support the project.

 

Profile of candidate’s qualifications: We look for highly motivated young scientists with interest in molecular genetics and cellular regulation. Practical experience in molecular biology, biochemistry or cell biology of plants will be of benefit. The applicants should hold a M.Sc. in Biology, Biochemistry or other relevant subjects. Successful acceptance at the Heidelberg Biosciences International Graduate School is expected for the PhD student.

The University of Heidelberg is an equal opportunity employer.

 

Profile of the host lab: The project is offered by the department of Plant Molecular Biology (www.cos.uni-heidelberg.de), which has a long-standing record to successfully graduated PhD students and a leading expertise in co-translation modification of proteins and the stress-induced regulation of translation in plants.

 

Please send your full application as a PDF file to sekretariat360@cos.uni-heidelberg.de

 

1.             Linster E, et al. Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis. Nat Commun 6, 7640 (2015).

2.            Xu F, et al. Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Plant Cell 27, 1547-1562 (2015).

 

Holstein group

Prof. Thomas Holstein 

Dr. Suat Özbek

Koch group

Please find descriptions of currently open positions within our department here.

Please contact Prof. Marcus Koch or Prof. Claudia Erbar directly. 

Dr. Anja Schmidt accepts applications for internships, Bachelor and Master projects.

Please contact  Dr. Anja Schmidt.

Kummer group

Prof. Ursula Kummer

Ingrid Lohmann group 

Prof. Ingrid Lohmann

The Developmental Biology Group (Prof. I. Lohmann) at the Centre for Organismal Studies (COS) in Heidelberg, Germany is looking for

POSTDOC AND/OR PHD STUDENT
to study stem cell behaviour in the Drosophila testis.

The Lohmann lab (http://ilohmann-lab.org) works on elucidating the role of HOX transcription factors in defining cell fate using Drosophila as a model. We are located at the Centre for Organismal Studies (COS) at the University of Heidelberg, Germany and part of the collaborative research network SFB873 “Maintenance and Differentiation of Stem Cells in Development and Disease” (https://www.cos.uni- heidelberg.de/index.php/sfb873?l=_e).
We now seek for enthusiastic new colleagues to analyze the interplay between germline stem cells and their support cells under homeostatic and compromised cellular conditions. In particular, the project aims at identifying pathways monitoring genome integrity in stem cells and at uncovering the role of mitotic checkpoint components in monitoring asymmetric stem cell division in the male germline. The project builds on a wide array of advanced resources established in the Lohmann lab and will provide ample opportunity to implement and apply high-end techniques to investigate stem cells of the Drosophila male stem cell system at multiple scales.
The Heidelberg Molecular Life Science Community offers a vibrant stem cell research community, as well as state-of-the-art core facilities. You will have the opportunity to closely collaborate with highly recognized stem cell researchers of the SFB873 and beyond.

Successful candidates will have experience in confocal microscopy, advanced immunohistochemistry and possibly in Drosophila genetics and molecular biology. The ability to quickly integrate into an interdisciplinary team and work independently within an academic research environment is essential. The position is immediately available, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered.

Applications should be sent to:
Prof. Dr. Ingrid Lohmann
Centre for Organismal Studies (COS) Heidelberg Im Neuenheimer Feld 267
D- 69120 Heidelberg, Germany ingrid.lohmann@cos.uni-heidelberg.de http://ilohmann-lab.org
  
Project-related publications:
1. Papagiannouli F, Schardt L, Grajcarek J, Ha N and Lohmann I (2014). The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Developmental Cell 28, 189-202.
2. Merabet S and Lohmann I (2015). Towards a new twist in Hox and TALE DNA- binding specificity. Developmental Cell 32(3):259-261.
3. Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU and Lohmann I (2018). Decoding the Regulatory Logic of the Drosophila Male Stem Cell System. Cell Reports 24(11):3072-3086.
4. Trost N, Rempel E, Ermakove O, Tamirisa S, Parcalabescu, Boutros M, Lohmann JU and Lohmann I (2018). WEADE: A workflow for enrichment analysis and data exploration. PLoS One 13(9):e0204016.

Group homepage

Jan Lohmann group

Prof. Jan Lohmann

Maizel group

Prof. Alexis Maizel  

Master Program

Open PhD positions

Pereira group

Prof. Gislene Pereira  

Pollerberg group

The “Developmental Neurobiology” group, member of the Center for Organismal Studies (COS) and the Interdisciplinary Center for Neurosciences (IZN), is looking for a highly motivated

Postdoc (f/m)

We are interested in the molecular basis of axon growth during development and regeneration. The Postdoc-project will focus on the interactions of cell adhesion molecules with other types of proteins and the impact of these interactions on axon elongation and navigation. Substantial amounts of data have already been collected for several projects; the Postdoc is therefore expected to complete and publish these studies. In addition to these basic research projects, also a new translational project could be started aiming at the improvement of axon regeneration. We are looking for a self-motivated person with a background in molecular and cellular biology, ideally in neurosciences.

We are a small but well equipped group with access to all facilities on the campus. The position is available (for up to 2 years) from 1st of April on (also a later start is possible); please send your applications until 10th of March. Payment will be according to German TV-L13 (full time; can be split). Please send your CV, relevant certificates, and a short letter of motivation (all documents as one pdf file) to G.E.Pollerberg@cos.uni-heidelberg. Preference will be given to equally qualified applicants with severe disabilities. For further inquiries, please do not hesitate to contact Elisabeth Pollerberg.

Stellen / Open Positions 

Prof. G.E. Pollerberg

Rausch group

Prof. Thomas Rausch
Dr. Steffen Greiner

Schumacher group

Prof. Karin Schumacher

Strahl group

Prof. Sabine Strahl 

Wittbrodt group

All PhD students in the Wittbrodt group are recruited through HBIGS 

For inquiries on openings on the Bachelor, Master or PostDoc level please contact Jochen Wittbrodt directly.

For the Braunbeck group please contact the group leader directly. 

Independent junior groups

Dr. Sergio Acebrón  

Dr. Lazaro Centanin  

Dr. Jan-Felix Evers  

Dr. Emmanuel Gaquerel  

Dr. Guido Grossmann  

Juniorprof. Dr. Steffen Lemke  

Dr. Michael Raissig  

Dr. Sebastian Wolf  

 

Metabolomics Core Technology Platform

Please contact Dr. Markus Wirtz

 

BBW-ForWerts

Prof.Thomas Rausch


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