Ruprecht-Karls-Universität Heidelberg
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Prof. Dr. Hermann-Josef Gröne

Prof. Dr. Hermann-Josef Gröne
Prof. Dr. Hermann-Josef Gröne
Im Neuenheimer Feld 280
69120 Heidelberg
Fon +49 6221 42 4350
h.-j.groene AET

Deutsches Krebsforschungszentrum 

Cellular and Molecular Pathology (G130)

The division performs research into the cellular and molecular mechanisms underlying rejection reactions in malignant tumors and transplanted solid organs. Rejection reactions are regularly mounted by the organism to defend itself against tumors. However, these are frequently not sufficient to fight the disease sustainably. 

Using organ transplants in animal models we can observe the course and characteristics of rejection under defined conditions. Our interest is focused on monocytes -- inflammation-promoting immune cells of the recipient -- and their main target: the endothelial cells coating the inside of the blood vessels of the donor organs. Two main groups of substances are studied with regard to the function of monocytes/macrophages, of endothelia and of parenchymal or tumor cells: lipid-activated nuclear receptors and glycosphingolipids. Our goal is to gain a better understanding of the processes underlying tissue rejection and to transfer these findings to tumor rejection. This may lead to novel diagnostic methods and treatment relating to tumor rejection. 

The division is also concerned with clinical surgical pathology and has established a reference center for renal diseases; it additionally provides a service for pathological analysis of tissue samples, including tissues from animal experiments. 

The department is funded by the DFG (German Research Foundation) in specific projects and is part of concerted research activities of the DFG.

/var/www/cos/ / Prof. Dr. Hermann-Josef Gröne