Ruprecht-Karls-Universität Heidelberg
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Prof. Dr. Karin Schumacher




Anne Kriegel, Zaida Andrés, Anna Medzihradszky, Falco Krüger, Stefan Scholl, Simon Delang, M. Görkem Patir-Nebioglu, Gezahegn Gute, Haibing Yang, Angus S. Murphy, Wendy Ann Peer, Anne Pfeiffer, Melanie Krebs, Jan U. Lohmann and Karin Schumacher (2015) Job Sharing in the Endomembrane System: Vacuolar Acidification Requires the Combined Activity of V-ATPase and V-PPase. Plant Cell, doi: 10.1105/tpc.15.00733


Yu Luo, Stefan Scholl, Anett Doering, Yi Zhang, Niloufer G. Irani, Simone Di Rubbo, Lutz Neumetzler, Praveen Krishnamoorthy, Isabelle Van Houtte, Evelien Mylle, Volker Bischoff, Samantha Vernhettes, Johan Winne, Jirí Friml, York-Dieter Stierhof, Karin Schumacher, Staffan Persson & Eugenia Russinova (2015) V-ATPase activity in the TGN/EE is required for exocytosis and recycling in Arabidopsis. Nature Plants 1, Article number: 15094, doi:10.1038/nplants.2015.94


Keinath NF, Waadt R, Brugman R, Schroeder JI, Grossmann G, Schumacher K, Krebs M. (2015) Live Cell Imaging with R-GECO1 Sheds Light on flg22- and Chitin-Induced Transient [Ca2+]cyt Patterns in Arabidopsis. Mol Plant. in press.


Wolf S, van der Does D, Ladwig F, Sticht C, Kolbeck A, Schürholz AK, Augustin S, Keinath N, Rausch T, Greiner S, Schumacher K, Harter K, Zipfel C, Höfte H. (2014) A receptor-like protein mediates the response to pectin modification by activating brassinosteroid signaling. Proc Natl Acad Sci U S A 111:15261-15266.


Schumacher K. (2014) pH in the plant endomembrane system - an import and export business. Curr Opin Plant Biol 22C:71–76.


Singh MK, Kruger F, Beckmann H, Brumm S, Vermeer JEM, Munnik T, Mayer U, Stierhof YD, Grefen C, Schumacher K, Jurgens G. (2014) Protein delivery to vacuole requires SAND protein-dependent Rab GTPase conversion for MVB-vacuole fusion. Curr Biol 24:1383-1389.


Andrés Z, Pérez-Hormaeche J, Leidi EO, Schlücking K, Steinhorst L, McLachlan DH, Schumacher K, Hetherington AM, Kudla J, Cubero B, Pardo JM. (2014) Control of vacuolar dynamics and regulation of stomatal aperture by tonoplast potassium uptake. Proc Natl Acad Sci U S A 111:1806-1814.


Fendrych M, Van Hautegem T, Van Durme M, Olvera-Carrillo Y, Huysmans M, Karimi M, Lippens S, Guerin CJ, Krebs M, Schumacher K, Nowack MK. (2014) Programmed Cell Death: New Role in Trimming the Root Tips. Curr Biol 24:931-934.


Eckert C, Offenborn JN, Heinz T, Armarego-Marriott T, Schultke S, Zhang C, Hillmer S, Heilmann M, Schumacher K, Bock R, Heilmann I, Kudla J. (2014) The vacuolar calcium sensors CBL2 and CBL3 affect seed size and embryonic development in Arabidopsis thaliana. Plant Journal 78:146-156.


Schuster, C., Gaillochet, C., Medzihradszky, A., Busch, W., Daum, G., Krebs, M., Kehle, A., and Lohmann, J.U. (2014) A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals. Developmental Cell, 28, 438-49.


Viotti C, Kruger F, Krebs M, Neubert C, Fink F, Lupanga U, David Scheuring, Boutté Y, Frescatada-Rosa M, Wolfenstetter S, Sauer N, Hillmer S, Grebe M, Schumacher K. (2013) The endoplasmic reticulum is the main membrane source for biogenesis of the lytic vacuole in Arabidopsis. Plant Cell 25:3434–3449.


Krebs M, Schumacher K. (2013) Live cell imaging of cytoplasmic and nuclear Ca2+ dynamics in Arabidopsis roots. Cold Spring Harb Protoc 8:776-780.


Krebs M, Held K, Binder A, Hashimoto K, Herder Den G, Parniske M, Kudla J, Schumacher K. (2012) FRET-based genetically encoded sensors allow high-resolution live cell imaging of Ca2+ dynamics. Plant Journal 69:181-192.


Scheuring D, Viotti C, Krüger F, Künzl F, Sturm S, Bubeck J, Hillmer S, Frigerio L, Robinson DG, Pimpl P, Schumacher K. (2011) Multivesicular bodies mature from the trans-Golgi network/early endosome in Arabidopsis. Plant Cell 23:3463–3481.


Drakakaki G, van de Ven W, Pan S, Miao Y, Wang J, Keinath NK, Weatherly B, Jiang L, Schumacher K, Hicks G, Raikhel N. (2011) Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis. Cell Res 1–12.


Schumacher K, Krebs M. (2010) The V-ATPase: small cargo, large effects. Curr Opin Plant Biol 13:724–730.


Grefen C, Donald N, Hashimoto K, Kudla J, Schumacher K, Blatt MR. (2010) A ubiquitin-10 promoter-based vector set for fluorescent protein tagging facilitates temporal stability and native protein distribution in transient and stable expression studies. Plant Journal 64:355–365.


Viotti C, Bubeck J, Stierhof Y-D, Krebs M, Langhans M, van den Berg W, van Dongen W, Richter S, Geldner N, Takano J, Jürgens G, de Vries SC, Robinson DG, Schumacher K. (2010) Endocytic and secretory traffic in Arabidopsis merge in the trans-Golgi network/early endosome, an independent and highly dynamic organelle. Plant Cell 22:1344–1357.


Krebs M, Beyhl D, Görlich E, Al-Rasheid KAS, Marten I, Stierhof Y-D, Hedrich R, Schumacher K. (2010) Arabidopsis V-ATPase activity at the tonoplast is required for efficient nutrient storage but not for sodium accumulation. Proc Natl Acad Sci USA 107:3251–3256.


Dettmer J, Liu T-Y, Schumacher K. (2010) Functional analysis of Arabidopsis V-ATPase subunit VHA-E isoforms. Eur J Cell Biol 89:152–156.


Schumacher K, Friml J. (2009) Cell biology. Curr Opin Plant Biol 12: 651–652.


Crowell EF, Bischoff V, Desprez T, Rolland A, Stierhof Y-D, Schumacher K, Gonneau M, Höfte H, Vernhettes S. (2008) Pausing of Golgi bodies on microtubules regulates secretion of cellulose synthase complexes in Arabidopsis. Plant Cell 21:1141–1154.


Dunkel M, Latz A, Schumacher K, Müller T, Becker D, Hedrich R. (2008)Targeting of vacuolar membrane localized members of the TPK channel family. Mol Plant 1:938–949.


Neubert C, Graham LA, Black-Maier EW, Coonrod EM, Liu T-Y, Stierhof Y-D, Seidel T, Stevens TH, Schumacher K. Arabidopsis has two functional orthologs of the yeast V-ATPase assembly factor Vma21p. Traffic 2008 Sep.;9(10):1618–1628.


Robinson DG, Jiang L, Schumacher K. (2008) The endosomal system of plants: charting new and familiar territories. Plant Physiol 147:1482–1492.


Brüx A, Liu T-Y, Krebs M, Stierhof Y-D, Lohmann JU, Miersch O, Wasternack C, Schumacher K. (2008) Reduced V-ATPase activity in the trans-Golgi network causes oxylipin-dependent hypocotyl growth Inhibition in Arabidopsis. Plant Cell 20:1088–1100.


Reichardt I, Stierhof Y-D, Mayer U, Richter S, Schwarz H, Schumacher K, Jürgens G. (2007)Plant cytokinesis requires de novo secretory trafficking but not endocytosis. Curr Biol 17:2047–2053.


Geldner N, Hyman DL, Wang X, Schumacher K, Chory J.(2007) Endosomal signaling of plant steroid receptor kinase BRI1. Genes Dev 21:1598–1602.


Gaxiola RA, Palmgren MG, Schumacher K. (2007) Plant proton pumps. FEBS Lett 581:2204–2214.


Fecht-Bartenbach von der J, Bogner M, Krebs M, Stierhof Y-D, Schumacher K, Ludewig U. (2007) Function of the anion transporter AtCLC-d in the trans-Golgi network. Plant Journal 50:466–474.


Alpi A, Amrhein N, Bertl A, Blatt MR, Blumwald E, Cervone F, Dainty J, De Michelis MI, Epstein E, Galston AW, Goldsmith MHM, Hawes C, Hell R, Hetherington A, Höfte H, Juergens G, Leaver CJ, Moroni A, Murphy A, Oparka K, Perata P, Quader H, Rausch T, Ritzenthaler C, Rivetta A, Robinson DG, Sanders D, Scheres B, Schumacher K, Sentenac H, Slayman CL, Soave C, Somerville C, Taiz L, Thiel G, Wagner R (2007). Plant neurobiology: no brain, no gain? Trends Plant Sci 12:135–136.


Schumacher K. (2006) Endomembrane proton pumps: connecting membrane and vesicle transport. Curr Opin Plant 9:595–600.


Dettmer J, Hong-Hermesdorf A, Stierhof Y-D, Schumacher K.(2006) Vacuolar H+-ATPase activity is required for endocytic and secretory trafficking in Arabidopsis. Plant Cell 18:715–730.


Hong-Hermesdorf A, Brüx A, Grüber A, Grüber G, Schumacher K.(2006) A WNK kinase binds and phosphorylates V-ATPase subunit C. FEBS Lett 580:932–939.


Armbrüster A, Hohn C, Hermesdorf A, Schumacher K, Börsch M, Grüber G. Evidence for major structural changes in subunit C of the vacuolar ATPase due to nucleotide binding. FEBS Lett 2005 Mar.;579(9):1961–1967.


Dettmer J, Schubert D, Calvo-Weimar O, Stierhof Y-D, Schmidt R, Schumacher K. (2005) Essential role of the V-ATPase in male gametophyte development. Plant 41:117–124.


Strompen G, Dettmer J, Stierhof Y-D, Schumacher K, Jürgens G, Mayer U. (2005) Arabidopsis vacuolar H-ATPase subunit E isoform 1 is required for Golgi organization and vacuole function in embryogenesis. Plant Journal 41:125–132.


Walter M, Chaban C, Schütze K, Batistic O, Weckermann K, Näke C, Blazevic D, Grefen C, Schumacher K, Oecking C, Harter K, Kudla J. (2004) Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation. Plant Journal 40:428–438.


Pélissier HC, Frerich A, Desimone M, Schumacher K, Tegeder M. (2004) PvUPS1, an allantoin transporter in nodulated roots of French bean. Plant Physiol 134:664–675.


Catoni E, Schwab R, Hilpert M, Desimone M, Schwacke R, Flügge UI, Schumacher K, Frommer WB. (2003) Identification of an Arabidopsis mitochondrial succinate-fumarate translocator. FEBS Lett 534:87–92.


Catoni E, Desimone M, Hilpert M, Wipf D, Kunze R, Schneider A, Flügge UI, Schumacher K, Frommer WB (2003). Expression pattern of a nuclear encoded mitochondrial arginine-ornithine translocator gene from Arabidopsis. BMC Plant Biol 3:1.


Desimone M, Catoni E, Ludewig U, Hilpert M, Schneider A, Kunze R, Tegeder M, Frommer WB, Schumacher K. (2002) A novel superfamily of transporters for allantoin and other oxo derivatives of nitrogen heterocyclic compounds in Arabidopsis. Plant Cell 14:847–856.


Sze H, Schumacher K, Müller ML, Padmanaban S, Taiz L. A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase. Trends Plant Sci 2002 Apr.;7(4):157–161.


Allen GJ, Chu SP, Harrington CL, Schumacher K, Hoffmann T, Tang YY, Grill E, Schroeder JI. (2001) A defined range of guard cell calcium oscillation parameters encodes stomatal movements. Nature 411:1053–1057.


Rossberg M, Theres K, Acarkan A, Herrero R, Schmitt T, Schumacher K, Schmitz G, Schmidt R. Comparative sequence analysis reveals extensive microcolinearity in the lateral suppressor regions of the tomato, Arabidopsis, and Capsella genomes. Plant Cell 2001 Apr.;13(4):979–988.


Allen GJ, Chu SP, Schumacher K, Shimazaki CT, Vafeados D, Kemper A, Hawke SD, Tallman G, Tsien RY, Harper JF, Chory J, Schroeder JI. (2000) Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science 289:2338–2342.


Schumacher K, Chory J.(2000) Brassinosteroid signal transduction: still casting the actors. Curr Opin Plant Biol 3:79–84.


Schumacher K, Vafeados D, McCarthy M, Sze H, Wilkins T, Chory J. (1999) The Arabidopsis det3 mutant reveals a central role for the vacuolar H(+)-ATPase in plant growth and development. Genes Dev 13: 3259–3270.


Schumacher K, Schmitt T, Rossberg M, Schmitz G, Theres K. (1999) The Lateral suppressor (Ls) gene of tomato encodes a new member of the VHIID protein family. Proc Natl Acad Sci USA 96:290–295.


/var/www/cos/ / Prof. Dr. Karin Schumacher