Ruprecht-Karls-Universität Heidelberg
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Molekulare Evolution und Genomik

apl. Prof. Dr. Suat Özbek

Selected Publications

Microbial arms race: Ballistic “nematocysts” in dinoflagellates represent a new extreme in organelle complexity.

Gavelis GS, Wakeman KC, Tillmann U, Ripken C, Mitarai S, Herranz M, Özbek S, Holstein T, Keeling PJ and Leander BS

Sci. Adv. 2017;3: e1602552.

 

Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.

Tursch A, Mercadante D, Tennigkeit J, Gräter F and Özbek S.

Scientific Rep. 2016 May 11; 6:25709.

 

Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation.

Brinkmann EM, Mattes B, Kumar R, Hagemann AI, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT and Özbek S.

J Biol Chem. 2016 Apr 29. pii: jbc.M116.733766

 

A fast recoiling silk-like elastomer facilitates nanosecond nematocyst discharge.

Beckmann A, Xiao S, Müller JP, Mercadante D, Nüchter T, Kröger N, Langhojer F, Petrich W, Holstein TW, Benoit M, Gräter F and Özbek S.

BMC Biol. 2015 Jan 16;13:3.

 

Nodal signalling determines biradial asymmetry in Hydra

Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW.

Nature. 2014 Aug 24. doi: 10.1038/nature13666.

 

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

Kumar S, Žigman M, Patel TR, Trageser B, Gross JC, Rahm K, Boutros M, Gradl D, Steinbeisser H, Holstein T, Stetefeld J and Özbek S.

BMC Biol. 2014 May 30;12:44. doi: 10.1186/1741-7007-12-44.

 

Proteome of Hydra nematocyst

Balasubramanian PG, Beckmann A, Warnken U, Schnölzer M, Schüler A, Bornberg-Bauer E, Holstein TW and Özbek S.

J Biol Chem. 2012 Mar 23;287(13):9672-81.

 

Morphological and molecular analysis of the Nematostella vectensis cnidom

Zenkert C, Takahashi T, Diesner MO and Özbek S.

PLoS One. 2011;6(7):e22725.

 

The evolution of extracellular matrix

Özbek S, Balasubramanian PG, Chiquet-Ehrismann R, Tucker RP and Adams JC.

Mol Biol Cell. 2010 Dec;21(24):4300-5.

 

A non-sulfated chondroitin stabilizes membrane tubulation in cnidarian organelles

Adamczyk P, Zenkert C, Balasubramanian GP, Yamada S, Murakoshi S, Sugahara K, Hwang HS, Gojobori T, Holstein TW and Özbek S.

J Biol Chem. 2010 Aug 13;285(33):25613-23.

 

The Dynamic Genome of Hydra

Chapman J,  Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Borman J, Busam D, Disbennett K,  Sumin N,  Sutton GG, Viswanathan LD, Walenz B,  Goodstein DM, Hellsten U, Kawashima T, Prochnik SE,Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Balasubramanian P, Bertulat B, Guder G, Nakamura Y, Özbek S, Watanabe H, Kalthurin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahasi T, Steinmetz PRH, Aufschnaiter R, Eder M, Gorny A, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TCG, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS and Steele R.

Nature 2010 Mar 25;464(7288):592-6.

 

Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts

Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bächinger HP, Holstein TW and Özbek S.

J Mol Biol., 2008 Feb;29376(4):1008-20.

 

Evolution of complex structures: minicollagens shape the cnidarian nematocyst

David CN, Özbek S, Adamczyk P, Meier S, Pauly B, Chapman J, Hwang JS, Gojobori T and Holstein TW.

Trends Genet. 2008 Sep;24(9):431-8.

 

Continuous molecular evolution of protein domain structures by single amino acid changes

Meier S, Jensen PR, David CN, Chapman J, Holstein TW, Grzesiek S and Özbek S.

Current Biology, 2007 January 23;17:173-178


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