Signal transduction & crosstalk
The extracellular signalling pathways are notorious for their cross talk, but it is still not well understood how stem and progenitor cells integrate different extracellular signals from a multi-signalling niche to modulate their fate and behaviour. We aim to characterise the fundamental molecular hubs where these signals converge.
Postdoctoral Positions in synthetic biology and cell biology
The Heidelberg molecular life sciences (HMLS) is a cross-institutional platform that includes the Heidelberg University, the EMBL, the Max Planck Institute for Medical Research, and the German Cancer Research Center (DKFZ). Within the framework of the University’s flagship initiative on molecular engineering, we are seeking:
Postdoctoral fellows in synthetic biology and cell biology
About the team: The selected candidates will join a collaborative project led by Sergio P. Acebrón (Heidelberg University), Gislene Pereira (Heidelberg University/DKFZ), Jan Ellenberg (EMBL), Rainer Pepperkok (EMBL), and Anna Marciniak-Czochra (Bioquant/IWR). Our work employs different biological models, technology platforms and mathematical tools to better understand cell signal transduction, cell division, and fate determination.
About the project: The project Synthetic DNA memories aims to develop novel molecular tools to record complex and transient cellular events into permanent and readable genetic memories. To drive this new collaborative project, we are looking for one postdoctoral fellow in the area of synthetic biology, and one in the area of cell biology. As a successful candidate, you will engage in one or several of the following areas:
· Design of synthetic biological circuits in yeast or mammalian cell culture
· Development of DNA-based memory devices controlled by recombinases and Cas endonucleases
· Characterisation of these tools in signal transduction and mitotic progression
· Development of scalable and robust analyses by single-cell sequencing, imaging or cytometry.
· Adaptation of these molecular devices to different biological questions and scales, from cells to organisms.
You have: A PhD or equivalent qualification in synthetic biology or molecular/cell biology. Experience with genome manipulation techniques (e.g. Cas9, Cas1-2). You are excited about designing and developing novel techniques. You enjoy interdisciplinary research, and you are capable of building and maintaining collaborations with team members working on different disciplines. Excellent communication skills in English.
You might have: Experience in mitosis, cell signalling, imaging or high-throughput analyses.
How to Apply: Interested applicants should send an email to firstname.lastname@example.org containing a pdf with 1) a cover letter that describes their motivation to pursue this position and summarizes past research accomplishments, 2) CV, including publications, and 3) contact information for two references.
Application deadline: 18 January 2020
About the position: The positions are initially funded for a period of 2 years (TV-L, 100% E13), with possibility of extension. The positions will be initially hosted at the Acebrón group at the Centre for Organismal Studies (COS, Heidelberg University). The researchers will have a close collaboration with the other groups of the team at the EMBL, COS and Bioquant to further develop the project.
The Heidelberg University is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
If you are interested in doing a Postdoc in the lab, please contact Sergio directly to discuss your project ideas and opportunities. Please provide a CV and a letter of recommendation (or the contact information of a referee).
PhD and MSc positions
We are looking for highly motivated students with a background in molecular cell biology, or similar. Please note that all PhD students will be integrated into the HBIGS graduate school at Heidelberg University. Please contact Sergio for inquiries for open PhD positions in the lab, as well as lab rotations for M.Sc. students.
We have an open position for a Master thesis. If you are interested, please send a CV and brief letter of motivation to Sergio Acebron (email@example.com). Provide a letter of recommendation, or the contact information of a referee.We have an open position for a Master thesis. If you are interested, please send a CV and brief letter of motivation to Sergio Acebron (firstname.lastname@example.org). Please provide a letter of recommendation, or the contact information of a referee.
Please contact Sergio for inquiries for open positions in the lab, as well as lab rotations.
More information in our group page.