Stammzellbiologie

SFB 873

Maintenance and Differentiation of Stem Cells
in Development and Disease

Leider gibt es keine deutsche Version dieser Seite.

Organization and Contact

A01	A02 (ended)	A03	B01	B02	B03	Z02	Z03	Z04
A06	A11	A12	B04	B06 (ended)	B07
A13 (ended)	A14	A16	B08	B09	B11
A17			B12	B13	B14

A01 Thomas Holstein

Veschgini M, Petersen HO, Abuillan W, Rossetti FF, Özbek S, Burghammer M, Holstein TW, Tanaka, M
Spatio-temporal elasticity pattern in extracellular matrix during Hydra morphogenesis
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079

Lommel M, Tursch A, Rustarazo-Calvo L, Trageser B, Holstein TW
Genetic knock-down and knock-out approaches in Hydra
bioRxiv 230300 doi: https://doi.org/10.1101/230300

Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T and Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); https://doi.org/10.1063/1.4943402

Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079

Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T and Holstein TW
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Nat Commun. 2014 Dec 23;5:5536. doi: 10.1038/ncomms6536

Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW
Nodal signalling determines biradial asymmetry in Hydra
Nature. 2014 Nov 6;515(7525):112-5. doi: 10.1038/nature13666

Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission
BMC Biol. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2.

Holstein TW
The evolution of the Wnt pathway
Cold Spring Harb Perspect Biol. 2012 Jul;4:a007922. doi: 10.1101/cshperspect.a007922

Somorjai IM, Lohmann JU, Holstein TW, Zhao Z
Stem cells: a view from the roots
Biotechnol J. 2012 Jun; 7:704-22. doi: 10.1002/biot.201100349

Holstein TW, Watanabe H, Ozbek S
Signaling pathways and axis formation in the lower metazoa
Curr Top Dev Biol. 2011;97:137-77. doi: 10.1016/B978-0-12-385975-4.00012-7

Nakamura Y, Tsiairis CD, Ozbek S, Holstein TW
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer
Proc Natl Acad Sci USA. 2011 May;108:9137-42. doi: 10.1073/pnas.1018109108

A02 Bruce Edgar

Jin Y, Patel P, Kohlmaier A, Pavlovic B, Zhang C, Edgar BA
Intestinal stem cell pool regulation in Drosophila
Stem Cell Reports. 2017 Jun;8:1479-1487. doi: 10.1016/j.stemcr.2017.04.002

Xiang J, Bandura J, Zhang P, Jin Y, Reuter H, Edgar BA
EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
Nat Commun. 2017 May;8:15125. doi: 10.1038/ncomms15125

Zhou J, Edgar BA, Boutros M
ATF3 acts as a rheostat to control JNK signaling during intestinal regeneration
Nature Commun 8:14289. 2017 Mar; doi:10.1038/ncomms14289

Jin Y, Ha N, Forés M, Xiang J, Gläßer C, Maldera J, Jiménez G, Edgar BA
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
PLoS Genet. 2015 Dec 18;11(12):e1005634. doi: 10.1371/journal.pgen.1005634

Patel PH, Dutta D, Edgar BA
Niche appropriation by Drosophila intestinal stem cell tumours
Nat Cell Biol. 2015 Sep;17(9):1182-92. doi: 10.1038/ncb3214

Dutta D, Buchon N, Xiang J, Edgar BA
Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations
Curr Protoc Stem Cell Biol. 2015 Aug 3;34:2F.2.1-14. doi: 10.1002/9780470151808.sc02f02s34

Dutta D, Dobson AJ, Houtz PL, Gläßer C, Revah J, Korzelius J, Patel PH, Edgar BA, Buchon N
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
Cell Rep. 2015 Jul 14;12(2):346-58. doi: 10.1016/j.celrep.2015.06.009

Zhou J, Florescu S, Boettcher AL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA, Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017

Kohlmaier A, Fassnacht CH, Reuter H, Begum J, Jin Y, Dutta D, Edgar BA
Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine
Oncogene 34:2371-84 PMID: 24975577; Apr 2015; doi:10.1038/onc.2014.163

Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA
Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells
EMBO J. 2014 Dec ;33:2967-82. doi: 10.15252/embj.201489072

A03 Joachim Wittbrodt

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug; 45:28-33. doi: 10.1016/j.gde.2017.02.002

Gutierrez-Triana JA, Mateo JL, Ibberson D, Ryu S,Wittbrodt J
iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins
Development. 143, 4272–4278; 2016 Nov 15. doi: 10.1242/dev.139261

Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development.143, 3470–3480; 2016 Oct 1. DOI: 10.1242/dev.134098

Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706

Stemmer M, Schuhmacher LN, Foulkes NS, Bertolucci C, Wittbrodt J
Cavefish eye loss in response to an early block in retinal differentiation progression
Development. 2015 Feb 15;142(4):743-52. doi: 10.1242/dev.114629

Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
PLoS One. 2015 Apr 24;10: e0124633. doi: 10.1371/journal.pone.0124633

Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892

Sinn R, Peravali R, Heermann S, Wittbrodt J
Differential responsiveness of distinct retinal domains to Atoh7
Mech Dev. 2014 Aug;133:218-29. doi: 10.1016/j.mod.2014.08.002

Centanin L, Wittbrodt J
Retinal neurogenesis
Development. 2014 Jan;141:241-4. doi: 10.1242/dev.083642

A06 Michael Boutros

Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the Regulatory Logic of the Drosophila Male Stem Cell System
Cell Rep. 2018 Sep 11; 24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013

Trost N, Rempel E, Ermakova O, Tamirisa S, Pârcâlâbescu L, Boutros M, Lohmann JU, Lohmann I
WEADE: A workflow for enrichment analysis and data exploration
PLoS One. 2018 Sep 28; 13(9):e0204016. doi: 10.1371/journal.pone.0204016

Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan;10. pii: eaah6829. doi: 10.1126/scisignal.aah6829

Zhou J, Edgar BA and Boutros M
ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration
Nat Commun. 2017; 8: 14289. online 2017 Mar 8. doi: 10.1038/ncomms14289

Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan 10;10(461). pii: eaah6829. doi: 10.1126/scisignal.aah6829

Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876

Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov. Doi: 10.1016/j.scr.2016.10.010

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell 36, 79–93. 2016 Jan 11. doi: 10.1016/j.devcel.2015.12.015

Brunk F, Augustin I, Meister M, Boutros M, Kyewski B
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
J Immunol. 2015 Dec 1;195(11):5261-71. doi: 10.4049/jimmunol.1501265

Erdmann G, Suchanek M, Horn P, Graf F, Volz C, Horn T, Zhang X, Wagner W, Ho AD, Boutros M
Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Genome Med. 2015 May 17;7(1):46. doi: 10.1186/s13073-015-0170-2

Zhou J, Florescu S, Boettcher A-LL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA and Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017

A11 Lázaro Centanin

Stolper J, Ambrosio EM, Danciu DP, Buono L, Elliott DA, Naruse K, Martínez-Morales JR, Marciniak-Czochra A, Centanin L
Stem cell topography splits growth and homeostatic functions in the fish gill
Elife. 2019 May 16;8. pii: e43747. doi: 10.7554/eLife.43747

Tsingos E, Höckendorf B, Sütterlin T, Kirchmaier S, Grabe N, Centanin L, Wittbrodt J
Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish
Elife. 2019 Mar 26;8. pii: e42646. doi: 10.7554/eLife.42646

Seleit A, Krämer I, Riebesehl B, Ambrosio EA, Stolper J, Dross N, Lischik C, Centanin L
Neural stem cells induce the formation of their physical niche during organogenesis
Elife. 2017 Sep;6. pii: e29173. doi: 10.7554/eLife.29173

Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development 144, 687–697. 2017 Feb15 doi: 10.1242/dev.142752

Lust K, Sinn R, Pérez Saturnino A, Centanin L, Wittbrodt J
De novo neurogenesis by targeted expression of atoh7 to Müller glia cells
Development. 2016 Jun ;143:1874-83. doi: 10.1242/dev.135905

A12 Claudia Scholl, Hanno Glimm

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007

Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels resembling IDHmut-driven DNA hypermethylation in AML stem cells
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294

Giessler KM, Kleinheinz K, Huebschmann D, Balasubramanian GP, Dubash TD, Dieter SM, Siegl C, Herbst F, Weber S, Hoffmann CM, Fronza R, Buchhalter I, Paramasivam N, Eils R, Schmidt M, von Kalle C, Schneider M, Ulrich A, Scholl C, Fröhling S, Weichert W, Brors B, Schlesner M, Ball CR, Glimm H
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
J Exp Med. 2017 Jul 3;214(7):2073-2088. doi: 10.1084/jem.20162017

Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J, Glimm H
Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts
EMBO Mol Med. 2017 Jul;9(7):918-932. doi: 10.15252/emmm.201607354

Rouhi A, Miller C, Grasedieck S, Reinhart S, Stolze B, Döhner H, Kuchenbauer F, Bullinger L, Fröhling S, Scholl C
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells
Oncotarget. 2017 Jan;8:7678-7690. doi: 10.18632/oncotarget.13841

Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Blood. 2016 Jun 9. doi: 10.1182/blood-2015-11-683581

Dubash TD, Hoffmann CM, Oppel F, Giessler KM, Weber S, Dieter SM, Hüllein J, Zenz T, Herbst F, Scholl C, Weichert W, Werft W, Benner A, Schmidt M, Schneider M, Glimm H, Ball CR
Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells
Cancer Lett. 2016 Feb 28. 371, 326-33. doi: 10.1016/j.canlet.2015.11.037

Stolze B, Reinhart S, Bulllinger L, Fröhling S, Scholl C
Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines
Sci Rep. 2015 Feb;5:8535. doi: 10.1038/srep08535

Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, Demir K, Boehm C, Leible S, Ball CR, Glimm H, Spang R, Boutros M
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
Nat Commun. 2013;4:2610. doi: 10.1038/ncomms3610

Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
J Exp Med. 2012 Apr;209:697-711. doi: 10.1084/jem.20111910

Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C, Glimm H
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
Cell Stem Cell. 2011 Oct;9:357-65. doi: 10.1016/j.stem.2011.08.010.

A13 Christoph Lutz

Wang W, Bochtler T, Wuchter P, Manta L, He H, Eckstein V, Ho AD, Lutz C
Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
Eur J Haematol. 2017 Nov;99:392-398. doi: 10.1111/ejh.12934

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May. 102, 1567-1577. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. 19: 271-281. doi: 10.1038/ncb3493

Wang W, Foerner E, Buss E, Jauch A, Eckstein V, Wuchter P, Ho AD, Lutz C
Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients
Leuk Lymphoma. 2016 Oct 13:1-9. DOI: 10.1080/10428194.2016.1236378.

Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct. 11, 51. DOI: 10.1186/s13062-016-0154-1

Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410

A14 Gislene Pereira

Maekawa H, Neuner A, Rüthnick D, Schiebel E, Pereira G, Kaneko Y
Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha
Elife. 2017 Aug;6. pii: e24340. doi: 10.7554/eLife.24340

Caydasi AK, Khmelinskii A, Duenas-Sanchez R, Kurtulmus B, Knop M, Pereira G
Temporal and compartment-specific signals coordinate mitotic exit with spindle position
Nat Commun. 2017 Jan. 8, 14129. doi: 10.1038/ncomms14129

Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, Martin-Villalba A, Pereira, G
The leucine-rich repeat protein LRRC45 indicates modular functions of distal appendages in ciliogenesis
BioRxiv, 205625; doi: https://doi.org/10.1101/205625

Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713

Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033

Klinger M, Wang W, Kuhns S, Barenz F, Drager-Meurer S, Pereira G, Gruss OJ
The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
Mol Biol Cell. 2014 Feb;25:495-507. doi: 10.1091/mbc.E13-09-0526

Schmidt KN, Kuhns S, Neuner A, Hub B, Zentgraf H, Pereira G
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
J Cell Biol. 2012 Dec;199:1083-101. doi: 10.1083/jcb.201202126

A16 Gergana Dobreva

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G
Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Cell Res. 2019 Jun;29(6):486-501. doi: 10.1038/s41422-019-0168-1

Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T
Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice
J Clin Invest. 2017 Jun;127:2235-2248. doi: 10.1172/JCI88725

Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G
Isl2b regulates anterior second heart field development in zebrafish
Sci Rep. 2017 Jan; 7: 41043.doi: 10.1038/srep41043

Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors
Cell Stem Cell. 2015 Sep;17:287-99. doi: 10.1016/j.stem.2015.08.007

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A
Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity
Stem Cells. 2015 Apr;33: 1113-29. doi: 10.1002/stem.1923

Cheedipudi S, Genolet O, Dobreva G
Epigenetic inheritance of cell fates during embryonic development.
Front Genet. 2014 Feb; 5: 19. doi: 10.3389/fgene.2014.00019

Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S
Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Circ Res. 2013 Sep ;113:856-62. doi: 10.1161/CIRCRESAHA.113.302035

Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity
Dev Cell. 2012 Jul;23:58-70. doi: 10.1016/j.devcel.2012.06.005

Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R
Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
Cell Stem Cell. 2010 Oct;7:496-507. doi: 10.1016/j.stem.2010.07.015

A17 Henrik Kaessmann

Sarropoulos I, Marin R, Cardoso-Moreira M, Kaessmann H
Developmental dynamics of lncRNAs across mammalian organs and species
Nature. 2019 Jun 26. doi: 10.1038/s41586-019-1341-x

Cardoso-Moreira M, Halbert J, Valloton D, Velten B, Chen C, Shao Y, Liechti A, Ascenção K, Rummel C, Ovchinnikova S, Mazin PV, Xenarios I, Harshman K, Mort M, Cooper DN, Sandi C, Soares MJ, Ferreira PG, Afonso S, Carneiro M, Turner JMA, VandeBerg JL, Fallahshahroudi A, Jensen P, Behr R, Lisgo S, Lindsay S, Khaitovich P, Huber W, Baker J, Anders S, Zhang YE, Kaessmann H
Gene expression across mammalian organ development
Nature. 2019 Jun 26. doi: 10.1038/s41586-019-1338-5

Guschanski K, Warnefors M, Kaessmann H
The evolution of duplicate gene expression in mammalian organs
Genome Res. 2017 Sep;27:1461-1474. doi: 10.1101/gr.215566.116

Carelli FN, Hayakawa T, Go Y, Imai H, Warnefors M, Kaessmann H
The life history of retrocopies illuminates the evolution of new mammalian genes
Genome Res. 2016 Mar;26:301-14. doi: 10.1101/gr.198473.115

Necsulea A, Kaessmann H
Evolutionary dynamics of coding and noncoding transcriptomes
Nat Rev Genet. 2014 Nov;15:734-48. doi: 10.1038/nrg3802

Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F, Kaessmann H
The evolution of lncRNA repertoires and expression patterns in tetrapods
Nature. 2014 Jan;505:635-40. doi: 10.1038/nature12943

Cortez D, Marin R, Toledo-Flores D, Froidevaux L, Liechti A, Waters PD, Grützner F, Kaessmann H
Origins and functional evolution of Y chromosomes across mammals
Nature. 2014 Apr;508:488-93. doi: 10.1038/nature13151

Soumillon M, Necsulea A, Weier M, Brawand D, Zhang X, Gu H, Barthès P, Kokkinaki M, Nef S, Gnirke A, Dym M, de Massy B, Mikkelsen TS, Kaessmann H
Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
Cell Rep. 2013 Jun;3:2179-90. doi: 10.1016/j.celrep.2013.05.031

Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H
Birth and expression evolution of mammalian microRNA genes
Genome Res. 2013 Jan;23:34-45. doi: 10.1101/gr.140269.112

Julien P, Brawand D, Soumillon M, Necsulea A, Liechti A, Schütz F, Daish T, Grützner F, Kaessmann H
Mechanisms and evolutionary patterns of mammalian and avian dosage compensation
PLoS Biol. 2012 May;10:e1001328. doi: 10.1371/journal.pbio.1001328

Brawand D, Soumillon M, Necsulea A, Julien P, Csárdi G, Harrigan P, Weier M, Liechti A, Aximu-Petri A, Kircher M, Albert FW, Zeller U, Khaitovich P, Grützner F, Bergmann S, Nielsen R, Pääbo S, Kaessmann, H
The evolution of gene expression levels in mammalian organs
Nature. 2011 Oct;478:343-8. doi: 10.1038/nature10532

Kaessmann H
Origins, evolution and phenotypic impact of new genes
Genome Res. 2010 Oct;20:1313-26. doi: 10.1101/gr.101386.109

B01 Jan Lohmann

Sloan J, Hakenjos JP, Gebert M, Ermakova O, Gumiero A, Stier G, Wild K, Sinning I & Lohmann J

Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
Nat Commun 11, 2223 (2020). doi:10.1038/s41467-020-16024-y

Ma Y, Miotk A, Šutikovi? Z, Ermakova O, Wenzl C, Medzihradszky A, Gaillochet C, Forner J, Utan G, Brackmann K, Galván-Ampudia CS, Vernoux T, Greb T, Lohmann J

WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis
Nat Commun 10, 5093 (2019) doi:10.1038/s41467-019-13074-9

Weits DA, Kunkowska AB, Kamps NCW, Portz KMS, Packbier NK, Nemec Venza Z, Gaillochet C, Lohmann JU, Pedersen O, van Dongen JT, Licausi F
An apical hypoxic niche sets the pace of shoot meristem activity
Nature. 2019 May;569(7758):714-717. doi: 10.1038/s41586-019-1203-6

Kim JY, Yang W, Forner J, Lohmann JU, Noh B, Noh YS
Epigenetic reprogramming by histone acetyltransferase HAG1/AtGCN5 is required for pluripotency acquisition in Arabidopsis
EMBO J. 2018 Oct 15;37(20). pii: e98726. doi: 10.15252/embj.201798726

Brackmann K, Qi J, Gebert M, Jouannet V, Schlamp T, Grünwald K, Wallner ES, Novikova DD, Levitsky VG, Agustí J, Sanchez P, Lohmann JU, Greb T
Spatial specificity of auxin responses coordinates wood formation
Nat Commun. 2018 Feb 28;9(1):875. doi: 10.1038/s41467-018-03256-2

Schuerholz AK, Lopez-Salmeron V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Vermeer JEM, Lohmann JU, Greb T, Wolf S
A Comprehensive Tool Set for Inducible, Cell Type-Specific Gene Expression in Arabidopsis
Plant Physiol. 2018 Sep;178(1):40-53. doi: 10.1104/pp.18.00463

Trost N, Rempel E, Ermakova O, Tamirisa S, Parcalabescu L, Boutros M, Lohmann JU, Lohmann I
WEADE: a workflow for enrichment analysis and data exploration
PLoS One. 2018 Sep 28;13(9):e0204016. doi: 10.1371/journal.pone.0204016

Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013

Gaillochet C, Jamge S, van der Wal F, Angenent G, Immink R, Lohmann JU
A molecular framework for functional versatility of HECATE transcription factors
Plant J. 2018 Jul;95(1):57-70. doi: 10.1111/tpj.13930

Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Pfeiffer A, Miotk A, Hakenjos J, Forner J, Yanofsky MF, Marciniack-Czochra A, Lohmann JU
Control of plant cell fate transitions by transcriptional and hormonal signals
Elife. 2017 Oct;6. pii: e30135. doi: 10.7554/eLife.30135

Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 26, R816-R821. 2016 Sep. doi: 10.1016/j.cub.2016.07.070

Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023

Schuster C, Gaillochet C, Lohmann JU
Arabidopsis HECATE genes function in phytohormone control during gynoecium development
Development. 2015 Oct;142:3343-50. doi: 10.1242/dev.120444

Gaillochet C, Lohmann JU
The never-ending story: from pluripotency to plant developmental plasticity
Development. 2015 Jul;142:2237-49. doi: 10.1242/dev.117614

Forner J, Pfeiffer A, Langenecker T, Manavella P, Lohmann JU
Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases
PLoS One. 2015 Mar 30;10(3):e0121056. doi: 10.1371/journal.pone.0121056

Gaillochet C, Daum G, Lohmann JU
O cell, where art thou? The mechanisms of shoot meristem patterning
Curr Opin Plant Biol. 2015 Feb;23:91-7. doi: 10.1016/j.pbi.2014.11.002

Yang H, von der Fecht-Bartenbach J, Friml J, Lohmann JU, Neuhäuser B and Ludewig U
Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with ammonium as the sole nitrogen source
Functional Plant Biology 42(3) 239-251 DOI: 10.1071/FP14171. Published: 24 October 2014

Daum G, Medzihradszky A, Suzaki T, Lohmann JU
A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14619-24. doi: 10.1073/pnas.1406446111

Vilarrasa-Blasi J, González-García MP, Frigola D, Fàbregas N, Alexiou KG, López-Bigas N, Rivas S, Jauneau A, Lohmann JU, Benfey PN, Ibañes M, Caño-Delgado AI
Regulation of plant stem cell quiescence by a brassinosteroid signaling module
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020

Schuster C, Gaillochet C, Medzihradszky A, Busch W, Daum G, Krebs M, Kehle A, Lohmann JU
A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals
Dev Cell. 2014 Feb;28:438-49. doi: 10.1016/j.devcel.2014.01.013

Lampropoulos A, Sutikovic Z, Wenzl C, Lohmann JU, Forner J
GreenGate - a novel, versatile, and efficient cloning system for plant transgenesis
PLoS One. 2013 Dec;8:e83043. doi: 10.1371/journal.pone.0083043

B02 Ingrid Lohmann

Domsch K, Papagiannouli F, Lohmann I
The HOX-Apoptosis Regulatory Interplay in Development and Disease
Curr Top Dev Biol. 2015;114:121-58. doi: 10.1016/bs.ctdb.2015.07.014

Schardt L, Ander JJ, Lohmann I, Papagiannouli F
Stage-specific control of niche positioning and integrity in the Drosophila testis
Mech Dev. 2015 Nov; 3:336-348. doi: 10.1016/j.mod.2015.07.009

Papagiannouli F, Lohmann I
Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B
Comput Struct Biotechnol J. 2015 Jan; 13:122-130. doi: 10.1016/j.csbj.2015.01.001

Papagiannouli F, Lohmann I
The Male Stem Cell Niche: insights from Drosophila and mammalian model systems, Tissue Specific Stem Cell Niche (“Stem Cell Biology and Regenerative Medicine” Series), Dr. Kursad Turksen (Ed.)
ISSN: 2196-8985, Springer Verlag (accepted; in print) (www.springer.com/series/7896?detailsPage=titles)

Papagiannouli F, Schardt L, Grajcarek J, Ha N, Lohmann I
The Hox gene Abd-B controls stem cell niche function in the Drosophila testis
Dev Cell. 2014 Jan; 28(2):189-202. doi: 10.1016/j.devcel.2013.12.016.

Papagiannouli F, Lohmann I
Shaping the niche: lessons from the Drosophila testis and other model systems
Biotechnol J. 2012 Jun. doi: 10.1002/biot.201100352

B03 Christof Niehrs

Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C
Angiopoietin-like 4 Is a WNT Signaling Antagonist that Promotes LRP6 Turnover
Dev Cell. 2017 Oct;43:71-82.e6. doi: 10.1016/j.devcel.2017.09.011.

Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C
Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6
EMBO Rep. 2017 May; 18, 712-725. doi: 10.15252/embr.201643585

Acebron SP, Niehrs C
β-Catenin-Independent Roles of WNT/LRP6 Signaling
Trends Cell Biol. 2016 Dec;26:956-967. doi: 10.1016/j.tcb.2016.07.009

Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C
Post-transcriptional WNT Signaling Governs Epididymal Sperm Maturation
Cell. 2015 Nov;163:1225-1236. doi: 10.1016/j.cell.2015.10.029

Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C
Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112

Perez-Acebron SP, Karaulanov E, Berger BS, Huang YL, Niehrs C
Mitotic wnt signaling promotes protein stabilization and regulates cell size
Mol Cell. 2014 May;54:663-74. doi: 10.1016/j.molcel.2014.04.014

Huang YL, Niehrs C
Polarized WNT Signaling Regulates Ectodermal Cell Fate in Xenopus
Dev Cell. 2014 Apr;29:250-7. doi: 10.1016/j.devcel.2014.03.015.

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A
Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037

B04 Andreas Trumpp

Paczulla AM, Rothfelder K, Raffel S, Konantz M, Steinbacher J, Wang H, Tandler C, Mbarga M, Schaefer T, Falcone M, Nievergall E, Dörfel D, Hanns P, Passweg JR, Lutz C, Schwaller J, Zeiser R, Blazar BR, Caligiuri MA, Dirnhofer S, Lundberg P, Kanz L, Quintanilla-Martinez L, Steinle A, Trumpp A, Salih HR, Lengerke C
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Nature. 2019 Jul 17. doi: 10.1038/s41586-019-1410-1

Eich M, Trumpp A, Schmitt S
OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel
Cytometry A. 2019 Jul 7. doi: 10.1002/cyto.a.23845

Sommerkamp P, Renders S, Ladel L, Hotz-Wagenblatt A, Schönberger K, Zeisberger P, Przybylla A, Sohn M, Zhou Y, Klibanski A, Cabezas-Wallscheid N, Trumpp A
The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells
Scientific Reports, 9(1), 2110. doi: 10.1038/s41598-019-38605-8 @: Shared corresponding author

Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
J Clin Invest. 2019 May 14;130:2745-2759. doi: 10.1172/JCI124738

Zviran A, Mor N, Rais Y, Gingold H, Peles S, Chomsky E, Viukov S, Buenrostro JD, Scognamiglio R, Weinberger L, Manor YS, Krupalnik V, Zerbib M, Hezroni H, Jaitin DA, Larastiaso D, Gilad S, Benjamin S, Gafni O, Mousa A, Ayyash M, Sheban D, Bayerl J, Aguilera-Castrejon A, Massarwa R, Maza I, Hanna S, Stelzer Y, Ulitsky I, Greenleaf WJ, Tanay A, Trumpp A, Amit I, Pilpel Y, Novershtern N, Hanna JH
Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
Cell Stem Cell. 2019 Jan 3 ;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015

Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells
Cell Stem Cell. 2019 Jan 3 ;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015

Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I
Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
Nat Cell Biol. 2018 Jul. 20(7):836-846. doi: 10.1038/s41556-018-0121-4

Haas S, Trumpp A, Milsom MD
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity
Cell Stem Cell. 2018 May 3; 22(5):627-638. doi: 10.1016/j.stem.2018.04.003

Haas S, Trumpp A
An Intrinsic Interferon Program Protects Stem Cells from Viral Infection
Dev Cell. 2018 Feb;44:279-280. doi: 10.1016/j.devcel.2018.01.013

Blume R, Rempel E, Manta L, Saeed BR, Wang W, Raffel S, Ermakova O, Eckstein V, Benes V, Trumpp A, Ho AD, Lutz C
The molecular signature of AML with increased ALDH activity suggests a stem cell origin
Leuk Lymphoma. 2018 Jan 16:1-10. doi: 10.1080/10428194.2017.1422862

Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA
Senescence-associated reprogramming promotes cancer stemness
Nature. 2018 Jan;553:96-100. doi: 10.1038/nature25167

Bahr C, Paleske Lv, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk A, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Nature 2018 Jan; 553:515–520. doi:10.1038/nature25193

Raffel S, Falcone M, Kneisel N, Hansson J, Wang W Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018

Sommerkamp P. and Trumpp A
Metabolic cues for hematopoietic stem cells
Science 02 Dec 2016: Vol. 354, Issue 6316, pp. 1103-1104, DOI: 10.1126/science.aal3466

Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenmann RN, Trumpp A, Shinohara T
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal
Genes Dev. 2016 Dec 1. doi: 10.1101/gad.287045.116

Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
Blood. 2016 Sep 1;doi: 10.1182/blood-2015-11-679167

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033

Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J
Selection and dynamics of embryonic stem cell integration into early mouse embryos
Development. 2016 Jan 1;143(1):24-34. doi: 10.1242/dev.124602

Morrison G, Scognamiglio R, Trumpp A, Smith A
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification
EMBO J. 2016 Jan 1;35(3):356-68. doi: 10.15252/embj.201592116

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013

Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition
Aging (Albany NY). 2015 Nov;7(11):911-27

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MAG, Williams DA, Trumpp A and Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131

Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E,Weichert W,Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR and Trumpp A
Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin
Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015

Tesio M, Tang Y, Mudder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp, A
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway
J Exp Med. 2015 Apr;212:525-38. doi: 10.1084/jem.20141438

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Brocks D, Gu L, Herrmann C, Haas S, Essers M, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis
Cell Stem Cell. 2014 Oct;15:507-522. doi: 10.1016/j.stem.2014.07.005

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wunsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C
Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Cell Cycle. 2014;13:3476-87. doi: 10.4161/15384101.2014.973334

Klimmeck D, Cabezas-Wallscheid N, Reyes A, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A
Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment
Stem Cell Reports. 2014 Nov; 3: 858–875

Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C, Lier A, Eisen C, Nowak V, Zens B, Müdder K, Klein C, Obländer J, Fey, S, Vogler J, Fabarius A, Riedl E, Roehl H, Kohlmann A, Staller M, Haferlach C, Müller N, John T, Platzbecker U, Metzgeroth G, Hofmann WK, Trumpp A, Nowak D
Myelodysplastic cells in patients re-program mesenchymal stromal cells to establish a transplantable stem cell-niche disease unit
Cell Stem Cell. 2014 Jun;14:824-37. doi: 10.1016/j.stem.2014.02.014

B06 Hellmut Augustin

Augustin HG, Koh GY
Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology
Science. 2017 Aug 3. pii: eaal2379. doi: 10.1126/science.aal2379

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG
Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nat Commun. 2017 Jul 18;8:16106. doi: 10.1038/ncomms16106

Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
EMBO Mol Med. 2017 Jun;9(6):741-749. doi: 10.15252/emmm.201607222

Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG
Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):495-505. doi: 10.1161/ATVBAHA.116.308455

Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation
Sci Signal. 2016 Apr; 9(425):ra42. doi: 10.1126/scisignal.aad3812

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell. 2016 Jan 11;36(1):79-93. doi: 10.1016/j.devcel.2015.12.015

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Freire Valls A, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG
The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024

Korn C, Augustin HG
Mechanisms of Vessel Pruning and Regression
Dev Cell. 2015 Jul 6;34(1):5-17. doi: 10.1016/j.devcel.2015.06.004.

Mogler C, Wieland M, Kö&nig C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG
Hepatic stellate cell-expressed Endosialin balances fibrogenesis and hepatocyte proliferation during liver damage
EMBO Mol Med. 2015 Mar;7:332-8. doi: 10.15252/emmm.201404246

Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG
Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat
Science. 2014 Jan; 343:416-9. doi: 10.1126/science.1244880

Korn C, Scholz B, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I
Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis
Development. 2014 Apr;141:1757-66. doi: 10.1242/dev.104422

Srivastava K, Ju J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG
Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy limits metastatic growth
Cancer Cell. 2014 Dec; 26:880-895. doi: 10.1016/j.ccell.2014.11.005

B07 Motomu Tanaka, Sascha Dietrich

Linke P, Suzuki R, Yamamoto A, Nakahata M, Kengaku M, Fujiwara T, Ohzono T, Tanaka M
Dynamic Contact Guidance of Myoblasts by Feature Size and Reversible Switching of Substrate Topography: Orchestration of Cell Shape, Orientation, and Nematic Ordering of Actin Cytoskeletons
Langmuir. 2018 Nov 8. doi: 10.1021/acs.langmuir.8b02972

Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima M, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K, Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L
Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells
Stem Cell Reports. 2018 Jul 10; 11(1):142-156. doi: 10.1016/j.stemcr.2018.06.003

Ohta T, Monzel C, Becker A, Ho AD, Tanaka M
Simple Physical Model Unravels Influences of Chemokine on Shape Deformation and Migration of Human Hematopoietic Stem Cells
Sci Rep. 2018 Jul 13; 8(1):10630. doi: 10.1038/s41598-018-28750-x

Monzel C, Becker AS, Saffrich R, Wuchter P, Eckstein V, Ho AD, Tanaka M
Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents
Sci Rep. 2018 Jan;8:1841. doi: 10.1038/s41598-018-19557-x

Dietrich S, Oles M, Sellner L, Anders S, Lu J, Velten B, Mock A, Oakes C, Sutton L, Young E, Rosenquist R, Rossi D, Zirlik K, Herling M, Nguyen-Khac F, Plass C, von Kalle C, Dürig J, Ringshausen I, Huber W, Zenz T
Drug Perturbation Based Stratification of Blood Cancer
J Clin Invest. 2018 Jan;128:427-445. doi: 10.1172/JCI93801

Hörnig M, Nakahata M, Linke P, Yamamoto A, Veschgini M, Kaufmann S, Takashima Y, Harada A, and Tanaka M
Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions
Sci Rep. 2017 Aug 9;7(1):7660. doi: 10.1038/s41598-017-07934-x

Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress
Cell Death Dis. 2016 Nov 10. doi: 10.1038/cddis.2016.342

Wuchter P, Vetter M, Saffrich R, Diehlmann A, Bieback K, Ho AD, Horn P
Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells
Exp Hematol. 2016 Jun doi: 10.1016/j.exphem.2016.02.004

Frank V, Kaufmann S, Wright R, Horn P, Yoshikawa HY, Wuchter P, Madsen J, Lewis AL, Armes SP, Ho AD, Tanaka M
Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency
Sci Rep. 2016 Apr 15;6:24264. doi: 10.1038/srep24264.

Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T, Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); doi: 10.1063/1.4943402

Wuchter P, Saffrich R, Giselbrecht S, Nies C, Lorig H, Kolb S, Ho AD, Gottwald E
Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells
Cell Tissue Res. 2016 Jan 30. doi:10.1007/s00441-015-2348-8

Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP, Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b

Monzel C, Veschgini M, Madsen J, Lewis AL, Armes SP, Tanaka M
Fine Adjustment of Interfacial Potential between pH-Responsive Hydrogels and Cell-Sized Particles
Langmuir. 2015 Aug 11;31(31):8689-96. doi: 10.1021/acs.langmuir.5b01896

Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD
Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells
Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370

Stiehl T, Baran N, Ho AD, Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508

Malcherek G, Jin N, Hückelhoven AG, Mani J, Wang L, Gern U, Diehlmann A, Wuchter P, Schmitt A, Chen B, Ho AD, Schmitt M
Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells
Leukemia. 2014 Dec;28(12):2388-94. doi: 10.1038/leu.2014.273

Wuchter P, Leinweber C, Saffrich R, Hanke M, Eckstein V, Ho AD, Grunze M, Rosenhahn A
Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells
Cell Tissue Res. 2014 Feb. doi: 10.1007/s00441-013-1759-7

Ludwig A, Saffrich R, Eckstein V, Bruckner T, Wagner W, Ho AD, Wuchter P
Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor
Cytotherapy. 2014 Jan doi: 10.1016/j.jcyt.2013.07.007

B08 Anna Marciniak- Czochra

Stiehl T, Marciniak-Czochra A
How to Characterize Stem Cells? Contributions from Mathematical Modeling
Current Stem Cell Reports, 5(2), 57-65, 2019, doi: 10.1007/s40778-019-00155-0

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Cell. 2019 Mar 7;176(6):1407-1419.e14. doi: 10.1016/j.cell.2019.01.040

Marciniak-Czochra A, Mikelic A, Stiehl T
Renormalization group second?order approximation for singularly perturbed nonlinear ordinary differential equations
Mathematical Methods in the Applied Sciences, Volume 41, Issue 14, doi.org/10.1002/mma.5107

Stiehl T, Ho AD, Marciniak-Czochra A
Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis
Scientific Reports. 2018 Jan. 8: 2809; doi:10.1038/s41598-018-21115-4

Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A
Revealing age-related changes of adult hippocampal neurogenesis using mathematical models
Development. 2018 Jan;145(1). pii: dev153544. doi: 10.1242/dev.153544

Stiehl T, Marciniak-Czochra A
Stem cell self-renewal in regeneration and cancer: Insights from mathematical modeling
Current Opinion in Systems Biology. 2017 Oct; 5:112-120. https://doi.org/10.1016/j.coisb.2017.09.006

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May; 102, 1567-1577 pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584

Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Dev Cell. 2016 Nov 7. 39, 289-301.doi: 10.1016/j.devcel.2016.10.002

Busse JE, Gwiazda P, Marciniak-Czochra A
Mass concentration in a nonlocal model of clonal selection
J Math Biol. 2016 Mar; 73, 1001-33. doi: 10.1007/s00285-016-0979-3

Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct;11:51. DOI: 10.1186/s13062-016-0154-1

Stiehl T, Baran N, Ho AD and Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508

Stiehl T, Baran N, Ho AD, Marciniak-Czochra A
Clonal selection and therapy resistance in acute leukemias: Mathematical modelling explains different proliferation patterns at diagnosis and relapse
J R Soc Interface. 2014 Mar;11:20140079. doi: 10.1098/rsif.2014.0079

Ziebell F, Martin-Villalba A, Marciniak-Czochra A
Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells
J R Soc Interface. 2014 Mar;11:20140144. doi: 10.1098/rsif.2014.0144

B09 Ana Martin- Villalba

Dehler S, Pak-Kin Lou W, Gao L, Skabkin M, Dällenbach S, Neumann A, Martin-Villalba A
An immune-CNS axis activates remote hippocampal stem cells following spinal transection injury
Front Mol Neurosci. 2018 Dec 11; 11: 443; doi: 10.3389/fnmol.2018.00443

Baser A, Skabkin M, Kleber S, Dang Y, Gülcüler Balta GS, Kalamakis G, Göpferich M, Ibañez DC, Schefzik R, Lopez AS, Bobadilla EL, Schultz C, Fischer B, Martin-Villalba A
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
Nature. 2019 Feb; 566(7742):100-104. doi: 10.1038/s41586-019-0888-x

Baser A, Skabkin M, Martin-Villalba A
Neural Stem Cell Activation and the Role of Protein Synthesis
Brain Plasticity. 2017 Nov; 3(1):27-41. DOI: 10.3233/BPL-160038

Llorens-Bobadilla E, Martin-Villalba A
Adult NSC diversity and plasticity: the role of the niche
Curr Opin Neurobiol. 2016 Dec; 42, 68-74. doi: 10.1016/j.conb.2016.11.008

Bifari F, Decimo I, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Cell Stem Cell. 2016 Nov; 20, 1-14. doi: 10.1016/j.stem.2016.10.020

Drachsler M, Kleber S, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
Cell Death Dis. 2016 Apr 28. doi: 10.1038/cddis.2016.102

Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
Cell Stem Cell. 2015 Sep; 17, 329-340 doi: 10.1016/j.stem.2015.07.002

Seib DR, Martin-Villalba A
Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Gerontology. 2015;61(4):327-35. doi: 10.1159/000368575. Issue release date: June 2015

Seib DRM, Corsini NS, Ellwanger K, Plass C, Mateos A, Pitzer C, Niehrs C, Celikel T, Martin-Villalba A
Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline
Cell Stem Cell. 2013 Feb;12:204-14. doi: 10.1016/j.stem.2012.11.010

Corsini N, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cell Stem Cell. 2009 Aug;5:178-90. doi: 10.1016/j.stem.2009.05.004.

B11 Hans-Reimer Rodewald, Thomas Höfer

Dorshkind K, Höfer T, Montecino-Rodriguez E, Pioli PD, Rodewald HR
Do haematopoietic stem cells age?
Nat Rev Immunol (2019) doi:10.1038/s41577-019-0236-2

Pei W, Wang X, Rössler J, Feyerabend TB, Höfer T, Rodewald HR
Using Cre-recombinase-driven Polylox barcoding for in vivo fate mapping in mice
Nat Protoc. 2019 Jun;14(6):1820-1840. doi: 10.1038/s41596-019-0163-5

Höfer T, Rodewald HR
Differentiation-based model of hematopoietic stem cell functions and lineage pathways
Blood. 2018 Sep 13; 132(11):1106-1113. doi: 10.1182/blood-2018-03-791517

Ryl T, Kuchen EE, Bell E, Shao C, Flórez AF, Mönke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T
Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug
Cell Syst. 2017 Sep; 5:237-250.e8. doi: 10.1016/j.cels.2017.07.005

Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Rode I, Klapproth K, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T, Rodewald HR
Polylox barcoding reveals hematopoietic stem cell fates realized in vivo
Nature. 2017 Aug;548:456-460. doi: 10.1038/nature23653.

Höfer T, Rodewald HR
Output without input: the lifelong productivity of hematopoietic stem cells
Curr Opin Cell Biol. 2016 Dec;43:69-77. doi: 10.1016/j.ceb.2016.08.003

Busch K, Rodewald HR
Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different
Curr Opin Hematol. 2016 Jul;23:295-303. doi: 10.1097/MOH.0000000000000250.

Höfer T, Barile M, Flossdorf M
Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system
Curr Opin Biotechnol. 2016 Jun;39:150-6. doi: 10.1016/j.copbio.2016.04.001

Klapproth K, Lasitschka F, Rodewald HR
Multilayered ancestry of arterial macrophages
Nat Immunol. 2016 Feb;17:117-8. doi: 10.1038/ni.3374.

Höfer T, Busch K, Klapproth K, Rodewald HR
Fate Mapping and Quantitation of Hematopoiesis In Vivo
Annu Rev Immunol. 2016 May; 34: 449–478. doi: 10.1146/annurev-immunol-032414-112019

Rode I, Martins VC, Küblbeck G, Maltry N, Tessmer C, Rodewald HR
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
J Immunol. 2015 Dec 15;195(12):5678-87. doi: 10.4049/jimmunol.1502010

Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T and Rodewald HR
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
Nature. 2015 Feb 26;518(7540):542-6. doi: 10.1038/nature14242

Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F and Rodewald HR
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Nature. 2015 Feb 26;518(7540):547-51. doi: 10.1038/nature13989

B12 Thomas Greb

Shi D, Lebovka I, López-Salmerón V, Sanchez P, Greb T
Bifacial cambium stem cells generate xylem and phloem during radial plant growth
Development. January 09, 2019. doi: 10.1242/dev.171355

Miyashima S, Roszak P, Sevilem I, Toyokura K, Blob B, Heo JO, Mellor N, Help-Rinta-Rahko H, Otero S, Smet W, Boekschoten M, Hooiveld G, Hashimoto K, Smetana O, Siligato R, Wallner ES, Mähönen AP, Kondo Y, Melnyk CW, Greb T, Nakajima K, Sozzani R, Bishopp A, De Rybel B, Helariutta Y
Mobile PEAR transcription factors integrate positional cues to prime cambial growth
Nature. January 09, 2019. doi: 10.1038/s41586-018-0839-y

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug;45:28-33. doi: 10.1016/j.gde.2017.02.002

Brackmann K, Qi J, Gebert M, Jouannet V, Qi J, Schlamp T, Grünwald K, Wallner ES, Novikova DD, Levitsky VG, Agusti J, Sanchez P, Lohmann J, Greb T
Spatial specificity of auxin responses coordinates wood formation
Nat Commun. 2018 Feb 28;9(1):875. doi: 10.1038/s41467-018-03256-2

Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 2016 Sep; 26(17):R816-R821. doi: 10.1016/j.cub.2016.07.070.

Wallner ES, López-Salmerón V, Greb T
Strigolactone versus gibberellin signaling: reemerging concepts?
Planta. 2016 Jun. doi: 10.1007/s00425-016-2478-6

Gursanscky NR, Jouannet V, Grünwald K, Sanchez P, Laaber-Schwarz M, Greb T
MOL1 is required for cambium homeostasis in Arabidopsis
Plant J. 2016 May; 86(3):210–220. doi: 10.1111/tpj.13169

B13 Michael Milsom, Marieke Essers

Prendergast ÁM, Kuck A, van Essen M, Haas S, Blaszkiewicz S, Essers MA
IFNa-mediated remodeling of endothelial cells in the bone marrow niche
Haematologica. 2017 Mar; 102: 445–453. doi: 10.3324/haematol.2016.151209

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann W-K, Ho AD, Huber W, Trumpp A, Essers MAG, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr;19:271-281. doi: 10.1038/ncb3493

Hirche C, Frenz T, Haas S, Döring M, Borst K, Tegtmeyer P, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U
Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo
Cell Rep. 2017 Jun; 19:2345-2356. doi: 10.1016/j.celrep.2017.05.063

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr;520:549-52. doi: 10.1038/nature14131

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors
Cell Stem Cell. 2015 Oct;17:422-34. doi: 10.1016/j.stem.2015.07.007

Kaschutnig P, Bogeska R, Walter D, Lier A, Huntscha S, Milsom MD
The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells
Cell Cycle. 2015 Jul;14:2734-42. doi: 10.1080/15384101.2015.1068474

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis
Cell Stem Cell. 2014 Oct;15:507-522. doi: 10.1016/j.stem.2014.07.005

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C
Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfate sequencing
Cell Cycle. 2014;13:3476-87. doi: 10.4161/15384101.2014.973334

Essers MAG, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A
IFNa activates dormant HSCs in vivo
Nature. 2009 Apr;458:904-8. doi: 10.1038/nature07815

B14 Carmen Ruiz de Almodóvar

Karakatsani A, Shah B, Ruiz de Almodóvar C
Blood Vessels as Regulators of Neural Stem Cell Properties
Front Mol Neurosci. 2019 Apr 12;12:85. doi: 10.3389/fnmol.2019.00085

Paredes I, Himmels P, Ruiz de Almodóvar C
Neurovascular Communication during CNS Development
Dev Cell. 2018 Apr;45:10-32. doi: 10.1016/j.devcel.2018.01.023

Wang X, Freire Valls A, Shermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C
YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis
Dev Cell. 2017 Sep;42:462-478.e7. doi: 10.1016/j.devcel.2017.08.002

Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A
CNS Macrophages Control Neurovascular Development via CD95L
Cell Rep. 2017 May;19:1378-1393. doi: 10.1016/j.celrep.2017.04.056

Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar;8:14583. doi: 10.1038/ncomms14583

Lange C, Storkebaum E, Ruiz de Almodóvar C, Dewerchin M, Carmeliet P
Vascular endothelial growth factor: a neurovascular target in neurological diseases
Nat Rev Neurol. 2016 Aug;12:439-54. doi: 10.1038/nrneurol.2016.88

Z02 Volker Eckstein, Carsten Müller-Tidow

Drachsler M, Kleber S, Mateos A, Volk K, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz C R, Mueller W, Synowitz M, Martin-Villalba A
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
Cell Death Dis. 2016 Apr;7:e2209. doi: 10.1038/cddis.2016.102.

Z03 Ulrike Engel

Beretta CA, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez-Triana JA, Paolini A, Poggi L, Falk J, Ryu S, Kapsimali M, Engel U, Carl M
Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting
Curr Biol. 2017 Jan;27:270-278. doi: 10.1016/j.cub.2016.11.038

Engel U
Four-Channel Super-Resolution Imaging by 3-D Structured Illumination
Methods Mol Biol. 2017;1663:79-94. doi: 10.1007/978-1-4939-7265-4_7

Seleit A, Kramer I, Riebesehl BF, Ambrosio EM, Stolper JS, Lischik CQ, Dross N, Centanin L
Neural stem cells induce the formation of their physical niche during organogenesis
Elife. 2017 Sep;6. pii: e29173. doi: 10.7554/eLife.29173

Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development. 2017 Feb; 144: 687-697. doi: 10.1242/dev.142752

Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C
YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
Dev Cell. 2017 Sep;42:462-478.e7. doi: 10.1016/j.devcel.2017.08.002

Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP and Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b

Marx A, Godinez WJ, Tsimashchuk V, Bankhead P, Rohr K, Engel U
Xenopus cytoplasmic linker-associated protein 1 (XCLASP1) promotes axon elongation and advance of pioneer microtubules
Mol Biol Cell. 2013 May; 24: 1544–1558. doi: 10.1091/mbc.E12-08-0573

Z04 Jan Lohmann, Henrik Kaessmann

Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov; 17, 607-615. doi: 10.1016/j.scr.2016.10.010

From:
Subject:

SFB 873

Maintenance and Differentiation of Stem Cells in Development and Disease

Maintenance and Differentiation of Stem Cells
in Development and Disease