SFB 873
Maintenance and Differentiation of Stem Cells
in Development and Disease
| A01 | A02 (ended) | A03 | B01 | B02 | B03 | Z02 | Z03 | Z04 |
| A06 | A11 | A12 | B04 | B06 (ended) | B07 | |||
| A13 (ended) | A14 | A16 | B08 | B09 | B11 | |||
| A17 | B12 | B13 | B14 |
Veschgini M, Petersen HO, Abuillan W, Rossetti FF, Özbek S, Burghammer M, Holstein TW, Tanaka, M
Spatio-temporal elasticity pattern in extracellular matrix during Hydra morphogenesis
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079
Lommel M, Tursch A, Rustarazo-Calvo L, Trageser B, Holstein TW
Genetic knock-down and knock-out approaches in Hydra
bioRxiv 230300 doi: https://doi.org/10.1101/230300
Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T and Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); https://doi.org/10.1063/1.4943402
Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079
Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T and Holstein TW
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Nat Commun. 2014 Dec 23;5:5536. doi: 10.1038/ncomms6536
Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW
Nodal signalling determines biradial asymmetry in Hydra
Nature. 2014 Nov 6;515(7525):112-5. doi: 10.1038/nature13666
Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission
BMC Biol. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2.
Holstein TW
The evolution of the Wnt pathway
Cold Spring Harb Perspect Biol. 2012 Jul;4:a007922. doi: 10.1101/cshperspect.a007922
Somorjai IM, Lohmann JU, Holstein TW, Zhao Z
Stem cells: a view from the roots
Biotechnol J. 2012 Jun; 7:704-22. doi: 10.1002/biot.201100349
Holstein TW, Watanabe H, Ozbek S
Signaling pathways and axis formation in the lower metazoa
Curr Top Dev Biol. 2011;97:137-77. doi: 10.1016/B978-0-12-385975-4.00012-7
Nakamura Y, Tsiairis CD, Ozbek S, Holstein TW
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer
Proc Natl Acad Sci USA. 2011 May;108:9137-42. doi: 10.1073/pnas.1018109108
Jin Y, Patel P, Kohlmaier A, Pavlovic B, Zhang C, Edgar BA
Intestinal stem cell pool regulation in Drosophila
Stem Cell Reports. 2017 Jun;8:1479-1487. doi: 10.1016/j.stemcr.2017.04.002
Xiang J, Bandura J, Zhang P, Jin Y, Reuter H, Edgar BA
EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
Nat Commun. 2017 May;8:15125. doi: 10.1038/ncomms15125
Zhou J, Edgar BA, Boutros M
ATF3 acts as a rheostat to control JNK signaling during intestinal regeneration
Nature Commun 8:14289. 2017 Mar; doi:10.1038/ncomms14289
Jin Y, Ha N, Forés M, Xiang J, Gläßer C, Maldera J, Jiménez G, Edgar BA
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
PLoS Genet. 2015 Dec 18;11(12):e1005634. doi: 10.1371/journal.pgen.1005634
Patel PH, Dutta D, Edgar BA
Niche appropriation by Drosophila intestinal stem cell tumours
Nat Cell Biol. 2015 Sep;17(9):1182-92. doi: 10.1038/ncb3214
Dutta D, Buchon N, Xiang J, Edgar BA
Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations
Curr Protoc Stem Cell Biol. 2015 Aug 3;34:2F.2.1-14. doi: 10.1002/9780470151808.sc02f02s34
Dutta D, Dobson AJ, Houtz PL, Gläßer C, Revah J, Korzelius J, Patel PH, Edgar BA, Buchon N
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
Cell Rep. 2015 Jul 14;12(2):346-58. doi: 10.1016/j.celrep.2015.06.009
Zhou J, Florescu S, Boettcher AL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA, Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017
Kohlmaier A, Fassnacht CH, Reuter H, Begum J, Jin Y, Dutta D, Edgar BA
Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine
Oncogene 34:2371-84 PMID: 24975577; Apr 2015; doi:10.1038/onc.2014.163
Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA
Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells
EMBO J. 2014 Dec ;33:2967-82. doi: 10.15252/embj.201489072
Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug; 45:28-33. doi: 10.1016/j.gde.2017.02.002
Gutierrez-Triana JA, Mateo JL, Ibberson D, Ryu S,Wittbrodt J
iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins
Development. 143, 4272–4278; 2016 Nov 15. doi: 10.1242/dev.139261
Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development.143, 3470–3480; 2016 Oct 1. DOI: 10.1242/dev.134098
Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706
Stemmer M, Schuhmacher LN, Foulkes NS, Bertolucci C, Wittbrodt J
Cavefish eye loss in response to an early block in retinal differentiation progression
Development. 2015 Feb 15;142(4):743-52. doi: 10.1242/dev.114629
Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
PLoS One. 2015 Apr 24;10: e0124633. doi: 10.1371/journal.pone.0124633
Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892
Sinn R, Peravali R, Heermann S, Wittbrodt J
Differential responsiveness of distinct retinal domains to Atoh7
Mech Dev. 2014 Aug;133:218-29. doi: 10.1016/j.mod.2014.08.002
Centanin L, Wittbrodt J
Retinal neurogenesis
Development. 2014 Jan;141:241-4. doi: 10.1242/dev.083642
Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the Regulatory Logic of the Drosophila Male Stem Cell System
Cell Rep. 2018 Sep 11; 24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013
Trost N, Rempel E, Ermakova O, Tamirisa S, Pârcâlâbescu L, Boutros M, Lohmann JU, Lohmann I
WEADE: A workflow for enrichment analysis and data exploration
PLoS One. 2018 Sep 28; 13(9):e0204016. doi: 10.1371/journal.pone.0204016
Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan;10. pii: eaah6829. doi: 10.1126/scisignal.aah6829
Zhou J, Edgar BA and Boutros M
ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration
Nat Commun. 2017; 8: 14289. online 2017 Mar 8. doi: 10.1038/ncomms14289
Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan 10;10(461). pii: eaah6829. doi: 10.1126/scisignal.aah6829
Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876
Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov. Doi: 10.1016/j.scr.2016.10.010
Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell 36, 79–93. 2016 Jan 11. doi: 10.1016/j.devcel.2015.12.015
Brunk F, Augustin I, Meister M, Boutros M, Kyewski B
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
J Immunol. 2015 Dec 1;195(11):5261-71. doi: 10.4049/jimmunol.1501265
Erdmann G, Suchanek M, Horn P, Graf F, Volz C, Horn T, Zhang X, Wagner W, Ho AD, Boutros M
Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Genome Med. 2015 May 17;7(1):46. doi: 10.1186/s13073-015-0170-2
Zhou J, Florescu S, Boettcher A-LL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA and Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017
Stolper J, Ambrosio EM, Danciu DP, Buono L, Elliott DA, Naruse K, Martínez-Morales JR, Marciniak-Czochra A, Centanin L
Stem cell topography splits growth and homeostatic functions in the fish gill
Elife. 2019 May 16;8. pii: e43747. doi: 10.7554/eLife.43747
Tsingos E, Höckendorf B, Sütterlin T, Kirchmaier S, Grabe N, Centanin L, Wittbrodt J
Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish
Elife. 2019 Mar 26;8. pii: e42646. doi: 10.7554/eLife.42646
Seleit A, Krämer I, Riebesehl B, Ambrosio EA, Stolper J, Dross N, Lischik C, Centanin L
Neural stem cells induce the formation of their physical niche during organogenesis
Elife. 2017 Sep;6. pii: e29173. doi: 10.7554/eLife.29173
Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development 144, 687–697. 2017 Feb15 doi: 10.1242/dev.142752
Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development.143, 3470–3480; 2016 Oct 1. DOI: 10.1242/dev.134098
Lust K, Sinn R, Pérez Saturnino A, Centanin L, Wittbrodt J
De novo neurogenesis by targeted expression of atoh7 to Müller glia cells
Development. 2016 Jun ;143:1874-83. doi: 10.1242/dev.135905
Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706
Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892
A12 Claudia Scholl, Hanno Glimm
Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels resembling IDHmut-driven DNA hypermethylation in AML stem cells
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294
Giessler KM, Kleinheinz K, Huebschmann D, Balasubramanian GP, Dubash TD, Dieter SM, Siegl C, Herbst F, Weber S, Hoffmann CM, Fronza R, Buchhalter I, Paramasivam N, Eils R, Schmidt M, von Kalle C, Schneider M, Ulrich A, Scholl C, Fröhling S, Weichert W, Brors B, Schlesner M, Ball CR, Glimm H
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
J Exp Med. 2017 Jul 3;214(7):2073-2088. doi: 10.1084/jem.20162017
Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J, Glimm H
Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts
EMBO Mol Med. 2017 Jul;9(7):918-932. doi: 10.15252/emmm.201607354
Rouhi A, Miller C, Grasedieck S, Reinhart S, Stolze B, Döhner H, Kuchenbauer F, Bullinger L, Fröhling S, Scholl C
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells
Oncotarget. 2017 Jan;8:7678-7690. doi: 10.18632/oncotarget.13841
Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Blood. 2016 Jun 9. doi: 10.1182/blood-2015-11-683581
Dubash TD, Hoffmann CM, Oppel F, Giessler KM, Weber S, Dieter SM, Hüllein J, Zenz T, Herbst F, Scholl C, Weichert W, Werft W, Benner A, Schmidt M, Schneider M, Glimm H, Ball CR
Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells
Cancer Lett. 2016 Feb 28. 371, 326-33. doi: 10.1016/j.canlet.2015.11.037
Stolze B, Reinhart S, Bulllinger L, Fröhling S, Scholl C
Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines
Sci Rep. 2015 Feb;5:8535. doi: 10.1038/srep08535
Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, Demir K, Boehm C, Leible S, Ball CR, Glimm H, Spang R, Boutros M
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
Nat Commun. 2013;4:2610. doi: 10.1038/ncomms3610
Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
J Exp Med. 2012 Apr;209:697-711. doi: 10.1084/jem.20111910
Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C, Glimm H
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
Cell Stem Cell. 2011 Oct;9:357-65. doi: 10.1016/j.stem.2011.08.010.
Wang W, Bochtler T, Wuchter P, Manta L, He H, Eckstein V, Ho AD, Lutz C
Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
Eur J Haematol. 2017 Nov;99:392-398. doi: 10.1111/ejh.12934
Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May. 102, 1567-1577. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584
Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. 19: 271-281. doi: 10.1038/ncb3493
Wang W, Foerner E, Buss E, Jauch A, Eckstein V, Wuchter P, Ho AD, Lutz C
Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients
Leuk Lymphoma. 2016 Oct 13:1-9. DOI: 10.1080/10428194.2016.1236378.
Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct. 11, 51. DOI: 10.1186/s13062-016-0154-1
Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410
Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007
Maekawa H, Neuner A, Rüthnick D, Schiebel E, Pereira G, Kaneko Y
Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha
Elife. 2017 Aug;6. pii: e24340. doi: 10.7554/eLife.24340
Caydasi AK, Khmelinskii A, Duenas-Sanchez R, Kurtulmus B, Knop M, Pereira G
Temporal and compartment-specific signals coordinate mitotic exit with spindle position
Nat Commun. 2017 Jan. 8, 14129. doi: 10.1038/ncomms14129
Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, Martin-Villalba A, Pereira, G
The leucine-rich repeat protein LRRC45 indicates modular functions of distal appendages in ciliogenesis
BioRxiv, 205625; doi: https://doi.org/10.1101/205625
Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713
Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033
Klinger M, Wang W, Kuhns S, Barenz F, Drager-Meurer S, Pereira G, Gruss OJ
The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
Mol Biol Cell. 2014 Feb;25:495-507. doi: 10.1091/mbc.E13-09-0526
Schmidt KN, Kuhns S, Neuner A, Hub B, Zentgraf H, Pereira G
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
J Cell Biol. 2012 Dec;199:1083-101. doi: 10.1083/jcb.201202126
Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G
Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate
Cell Res. 2019 Jun;29(6):486-501. doi: 10.1038/s41422-019-0168-1
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T
Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice
J Clin Invest. 2017 Jun;127:2235-2248. doi: 10.1172/JCI88725
Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G
Isl2b regulates anterior second heart field development in zebrafish
Sci Rep. 2017 Jan; 7: 41043.doi: 10.1038/srep41043
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors
Cell Stem Cell. 2015 Sep;17:287-99. doi: 10.1016/j.stem.2015.08.007
Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A
Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity
Stem Cells. 2015 Apr;33: 1113-29. doi: 10.1002/stem.1923
Cheedipudi S, Genolet O, Dobreva G
Epigenetic inheritance of cell fates during embryonic development.
Front Genet. 2014 Feb; 5: 19. doi: 10.3389/fgene.2014.00019
Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S
Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Circ Res. 2013 Sep ;113:856-62. doi: 10.1161/CIRCRESAHA.113.302035
Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity
Dev Cell. 2012 Jul;23:58-70. doi: 10.1016/j.devcel.2012.06.005
Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R
Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
Cell Stem Cell. 2010 Oct;7:496-507. doi: 10.1016/j.stem.2010.07.015
Sarropoulos I, Marin R, Cardoso-Moreira M, Kaessmann H
Developmental dynamics of lncRNAs across mammalian organs and species
Nature. 2019 Jun 26. doi: 10.1038/s41586-019-1341-x
Cardoso-Moreira M, Halbert J, Valloton D, Velten B, Chen C, Shao Y, Liechti A, Ascenção K, Rummel C, Ovchinnikova S, Mazin PV, Xenarios I, Harshman K, Mort M, Cooper DN, Sandi C, Soares MJ, Ferreira PG, Afonso S, Carneiro M, Turner JMA, VandeBerg JL, Fallahshahroudi A, Jensen P, Behr R, Lisgo S, Lindsay S, Khaitovich P, Huber W, Baker J, Anders S, Zhang YE, Kaessmann H
Gene expression across mammalian organ development
Nature. 2019 Jun 26. doi: 10.1038/s41586-019-1338-5
Guschanski K, Warnefors M, Kaessmann H
The evolution of duplicate gene expression in mammalian organs
Genome Res. 2017 Sep;27:1461-1474. doi: 10.1101/gr.215566.116
Carelli FN, Hayakawa T, Go Y, Imai H, Warnefors M, Kaessmann H
The life history of retrocopies illuminates the evolution of new mammalian genes
Genome Res. 2016 Mar;26:301-14. doi: 10.1101/gr.198473.115
Necsulea A, Kaessmann H
Evolutionary dynamics of coding and noncoding transcriptomes
Nat Rev Genet. 2014 Nov;15:734-48. doi: 10.1038/nrg3802
Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F, Kaessmann H
The evolution of lncRNA repertoires and expression patterns in tetrapods
Nature. 2014 Jan;505:635-40. doi: 10.1038/nature12943
Cortez D, Marin R, Toledo-Flores D, Froidevaux L, Liechti A, Waters PD, Grützner F, Kaessmann H
Origins and functional evolution of Y chromosomes across mammals
Nature. 2014 Apr;508:488-93. doi: 10.1038/nature13151
Soumillon M, Necsulea A, Weier M, Brawand D, Zhang X, Gu H, Barthès P, Kokkinaki M, Nef S, Gnirke A, Dym M, de Massy B, Mikkelsen TS, Kaessmann H
Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
Cell Rep. 2013 Jun;3:2179-90. doi: 10.1016/j.celrep.2013.05.031
Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H
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Genome Res. 2013 Jan;23:34-45. doi: 10.1101/gr.140269.112
Julien P, Brawand D, Soumillon M, Necsulea A, Liechti A, Schütz F, Daish T, Grützner F, Kaessmann H
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PLoS Biol. 2012 May;10:e1001328. doi: 10.1371/journal.pbio.1001328
Brawand D, Soumillon M, Necsulea A, Julien P, Csárdi G, Harrigan P, Weier M, Liechti A, Aximu-Petri A, Kircher M, Albert FW, Zeller U, Khaitovich P, Grützner F, Bergmann S, Nielsen R, Pääbo S, Kaessmann, H
The evolution of gene expression levels in mammalian organs
Nature. 2011 Oct;478:343-8. doi: 10.1038/nature10532
Kaessmann H
Origins, evolution and phenotypic impact of new genes
Genome Res. 2010 Oct;20:1313-26. doi: 10.1101/gr.101386.109
Sloan J, Hakenjos JP, Gebert M, Ermakova O, Gumiero A, Stier G, Wild K, Sinning I & Lohmann J
Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL
Nat Commun 11, 2223 (2020). doi:10.1038/s41467-020-16024-y
Ma Y, Miotk A, Šutikovi? Z, Ermakova O, Wenzl C, Medzihradszky A, Gaillochet C, Forner J, Utan G, Brackmann K, Galván-Ampudia CS, Vernoux T, Greb T, Lohmann J
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Nat Commun 10, 5093 (2019) doi:10.1038/s41467-019-13074-9
Weits DA, Kunkowska AB, Kamps NCW, Portz KMS, Packbier NK, Nemec Venza Z, Gaillochet C, Lohmann JU, Pedersen O, van Dongen JT, Licausi F
An apical hypoxic niche sets the pace of shoot meristem activity
Nature. 2019 May;569(7758):714-717. doi: 10.1038/s41586-019-1203-6
Kim JY, Yang W, Forner J, Lohmann JU, Noh B, Noh YS
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EMBO J. 2018 Oct 15;37(20). pii: e98726. doi: 10.15252/embj.201798726
Brackmann K, Qi J, Gebert M, Jouannet V, Schlamp T, Grünwald K, Wallner ES, Novikova DD, Levitsky VG, Agustí J, Sanchez P, Lohmann JU, Greb T
Spatial specificity of auxin responses coordinates wood formation
Nat Commun. 2018 Feb 28;9(1):875. doi: 10.1038/s41467-018-03256-2
Schuerholz AK, Lopez-Salmeron V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Vermeer JEM, Lohmann JU, Greb T, Wolf S
A Comprehensive Tool Set for Inducible, Cell Type-Specific Gene Expression in Arabidopsis
Plant Physiol. 2018 Sep;178(1):40-53. doi: 10.1104/pp.18.00463
Trost N, Rempel E, Ermakova O, Tamirisa S, Parcalabescu L, Boutros M, Lohmann JU, Lohmann I
WEADE: a workflow for enrichment analysis and data exploration
PLoS One. 2018 Sep 28;13(9):e0204016. doi: 10.1371/journal.pone.0204016
Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013
Gaillochet C, Jamge S, van der Wal F, Angenent G, Immink R, Lohmann JU
A molecular framework for functional versatility of HECATE transcription factors
Plant J. 2018 Jul;95(1):57-70. doi: 10.1111/tpj.13930
Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Pfeiffer A, Miotk A, Hakenjos J, Forner J, Yanofsky MF, Marciniack-Czochra A, Lohmann JU
Control of plant cell fate transitions by transcriptional and hormonal signals
Elife. 2017 Oct;6. pii: e30135. doi: 10.7554/eLife.30135
Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 26, R816-R821. 2016 Sep. doi: 10.1016/j.cub.2016.07.070
Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023
Schuster C, Gaillochet C, Lohmann JU
Arabidopsis HECATE genes function in phytohormone control during gynoecium development
Development. 2015 Oct;142:3343-50. doi: 10.1242/dev.120444
Gaillochet C, Lohmann JU
The never-ending story: from pluripotency to plant developmental plasticity
Development. 2015 Jul;142:2237-49. doi: 10.1242/dev.117614
Forner J, Pfeiffer A, Langenecker T, Manavella P, Lohmann JU
Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases
PLoS One. 2015 Mar 30;10(3):e0121056. doi: 10.1371/journal.pone.0121056
Gaillochet C, Daum G, Lohmann JU
O cell, where art thou? The mechanisms of shoot meristem patterning
Curr Opin Plant Biol. 2015 Feb;23:91-7. doi: 10.1016/j.pbi.2014.11.002
Yang H, von der Fecht-Bartenbach J, Friml J, Lohmann JU, Neuhäuser B and Ludewig U
Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with ammonium as the sole nitrogen source
Functional Plant Biology 42(3) 239-251 DOI: 10.1071/FP14171. Published: 24 October 2014
Daum G, Medzihradszky A, Suzaki T, Lohmann JU
A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14619-24. doi: 10.1073/pnas.1406446111
Vilarrasa-Blasi J, González-García MP, Frigola D, Fàbregas N, Alexiou KG, López-Bigas N, Rivas S, Jauneau A, Lohmann JU, Benfey PN, Ibañes M, Caño-Delgado AI
Regulation of plant stem cell quiescence by a brassinosteroid signaling module
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020
Schuster C, Gaillochet C, Medzihradszky A, Busch W, Daum G, Krebs M, Kehle A, Lohmann JU
A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals
Dev Cell. 2014 Feb;28:438-49. doi: 10.1016/j.devcel.2014.01.013
Lampropoulos A, Sutikovic Z, Wenzl C, Lohmann JU, Forner J
GreenGate - a novel, versatile, and efficient cloning system for plant transgenesis
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Trost N, Rempel E, Ermakova O, Tamirisa S, Parcalabescu L, Boutros M, Lohmann JU, Lohmann I
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Tamirisa S, Papagiannouli F, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
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Cell Rep. 2018 Sep 11;24(11):3072-3086. doi: 10.1016/j.celrep.2018.08.013
Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007
Domsch K, Papagiannouli F, Lohmann I
The HOX-Apoptosis Regulatory Interplay in Development and Disease
Curr Top Dev Biol. 2015;114:121-58. doi: 10.1016/bs.ctdb.2015.07.014
Schardt L, Ander JJ, Lohmann I, Papagiannouli F
Stage-specific control of niche positioning and integrity in the Drosophila testis
Mech Dev. 2015 Nov; 3:336-348. doi: 10.1016/j.mod.2015.07.009
Papagiannouli F, Lohmann I
Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B
Comput Struct Biotechnol J. 2015 Jan; 13:122-130. doi: 10.1016/j.csbj.2015.01.001
Papagiannouli F, Lohmann I
The Male Stem Cell Niche: insights from Drosophila and mammalian model systems, Tissue Specific Stem Cell Niche (“Stem Cell Biology and Regenerative Medicine” Series), Dr. Kursad Turksen (Ed.)
ISSN: 2196-8985, Springer Verlag (accepted; in print) (www.springer.com/series/7896?detailsPage=titles)
Papagiannouli F, Schardt L, Grajcarek J, Ha N, Lohmann I
The Hox gene Abd-B controls stem cell niche function in the Drosophila testis
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Shaping the niche: lessons from the Drosophila testis and other model systems
Biotechnol J. 2012 Jun. doi: 10.1002/biot.201100352
Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C
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Trends Cell Biol. 2016 Dec;26:956-967. doi: 10.1016/j.tcb.2016.07.009
Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C
Post-transcriptional WNT Signaling Governs Epididymal Sperm Maturation
Cell. 2015 Nov;163:1225-1236. doi: 10.1016/j.cell.2015.10.029
Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C
Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112
Perez-Acebron SP, Karaulanov E, Berger BS, Huang YL, Niehrs C
Mitotic wnt signaling promotes protein stabilization and regulates cell size
Mol Cell. 2014 May;54:663-74. doi: 10.1016/j.molcel.2014.04.014
Huang YL, Niehrs C
Polarized WNT Signaling Regulates Ectodermal Cell Fate in Xenopus
Dev Cell. 2014 Apr;29:250-7. doi: 10.1016/j.devcel.2014.03.015.
Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A
Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037
Paczulla AM, Rothfelder K, Raffel S, Konantz M, Steinbacher J, Wang H, Tandler C, Mbarga M, Schaefer T, Falcone M, Nievergall E, Dörfel D, Hanns P, Passweg JR, Lutz C, Schwaller J, Zeiser R, Blazar BR, Caligiuri MA, Dirnhofer S, Lundberg P, Kanz L, Quintanilla-Martinez L, Steinle A, Trumpp A, Salih HR, Lengerke C
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Nature. 2019 Jul 17. doi: 10.1038/s41586-019-1410-1
Eich M, Trumpp A, Schmitt S
OMIP-059: Identification of Mouse Hematopoietic Stem and Progenitor Cells with Simultaneous Detection of CD45.1/2 and Controllable Green Fluorescent Protein Expression by a Single Staining Panel
Cytometry A. 2019 Jul 7. doi: 10.1002/cyto.a.23845
Sommerkamp P, Renders S, Ladel L, Hotz-Wagenblatt A, Schönberger K, Zeisberger P, Przybylla A, Sohn M, Zhou Y, Klibanski A, Cabezas-Wallscheid N, Trumpp A
The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells
Scientific Reports, 9(1), 2110. doi: 10.1038/s41598-019-38605-8 @: Shared corresponding author
Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF
Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
J Clin Invest. 2019 May 14;130:2745-2759. doi: 10.1172/JCI124738
Zviran A, Mor N, Rais Y, Gingold H, Peles S, Chomsky E, Viukov S, Buenrostro JD, Scognamiglio R, Weinberger L, Manor YS, Krupalnik V, Zerbib M, Hezroni H, Jaitin DA, Larastiaso D, Gilad S, Benjamin S, Gafni O, Mousa A, Ayyash M, Sheban D, Bayerl J, Aguilera-Castrejon A, Massarwa R, Maza I, Hanna S, Stelzer Y, Ulitsky I, Greenleaf WJ, Tanay A, Trumpp A, Amit I, Pilpel Y, Novershtern N, Hanna JH
Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
Cell Stem Cell. 2019 Jan 3 ;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015
Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells
Cell Stem Cell. 2019 Jan 3 ;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015
Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I
Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
Nat Cell Biol. 2018 Jul. 20(7):836-846. doi: 10.1038/s41556-018-0121-4
Haas S, Trumpp A, Milsom MD
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity
Cell Stem Cell. 2018 May 3; 22(5):627-638. doi: 10.1016/j.stem.2018.04.003
Haas S, Trumpp A
An Intrinsic Interferon Program Protects Stem Cells from Viral Infection
Dev Cell. 2018 Feb;44:279-280. doi: 10.1016/j.devcel.2018.01.013
Blume R, Rempel E, Manta L, Saeed BR, Wang W, Raffel S, Ermakova O, Eckstein V, Benes V, Trumpp A, Ho AD, Lutz C
The molecular signature of AML with increased ALDH activity suggests a stem cell origin
Leuk Lymphoma. 2018 Jan 16:1-10. doi: 10.1080/10428194.2017.1422862
Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA
Senescence-associated reprogramming promotes cancer stemness
Nature. 2018 Jan;553:96-100. doi: 10.1038/nature25167
Bahr C, Paleske Lv, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk A, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Nature 2018 Jan; 553:515–520. doi:10.1038/nature25193
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018
Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. 19; 271-281. doi: 10.1038/ncb3493
Sommerkamp P. and Trumpp A
Metabolic cues for hematopoietic stem cells
Science 02 Dec 2016: Vol. 354, Issue 6316, pp. 1103-1104, DOI: 10.1126/science.aal3466
Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenmann RN, Trumpp A, Shinohara T
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal
Genes Dev. 2016 Dec 1. doi: 10.1101/gad.287045.116
Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
Blood. 2016 Sep 1;doi: 10.1182/blood-2015-11-679167
Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033
Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J
Selection and dynamics of embryonic stem cell integration into early mouse embryos
Development. 2016 Jan 1;143(1):24-34. doi: 10.1242/dev.124602
Morrison G, Scognamiglio R, Trumpp A, Smith A
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification
EMBO J. 2016 Jan 1;35(3):356-68. doi: 10.15252/embj.201592116
Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013
Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition
Aging (Albany NY). 2015 Nov;7(11):911-27
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007
Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410
Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MAG, Williams DA, Trumpp A and Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131
Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E,Weichert W,Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR and Trumpp A
Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin
Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015
Tesio M, Tang Y, Mudder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp, A
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway
J Exp Med. 2015 Apr;212:525-38. doi: 10.1084/jem.20141438
Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Brocks D, Gu L, Herrmann C, Haas S, Essers M, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis
Cell Stem Cell. 2014 Oct;15:507-522. doi: 10.1016/j.stem.2014.07.005
Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wunsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C
Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Cell Cycle. 2014;13:3476-87. doi: 10.4161/15384101.2014.973334
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