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Stem Cell Biology

SFB 873

Maintenance and Differentiation of Stem Cells
in Development and Disease

 

A01 A02 (ended) A03 B01 B02 B03 Z02 Z03 Z04
A06 A11 A12 B04 B06 (ended) B07
A13 (ended) A14 A16 B08 B09 B11
A17     B12 B13 B14

 

A01 Thomas Holstein

Veschgini M, Petersen HO, Abuillan W, Rossetti FF, Özbek S, Burghammer M, Holstein TW, Tanaka, M
Spatio-temporal elasticity pattern in extracellular matrix during Hydra morphogenesis
bioRxiv doi: 10.1101/214718


Lommel M, Tursch A, Rustarazo-Calvo L, Trageser B, Holstein TW
Genetic knock-down and knock-out approaches in Hydra
bioRxiv 230300 doi: https://doi.org/10.1101/230300


Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T and Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); https://doi.org/10.1063/1.4943402


Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079


Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T and Holstein TW
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Nat Commun. 2014 Dec 23;5:5536. doi: 10.1038/ncomms6536


Watanabe H, Schmidt HA, Kuhn A, Höger SK, Kocagöz Y, Laumann-Lipp N, Özbek S and Holstein TW
Nodal signalling determines biradial asymmetry in Hydra
Nature. 2014 Nov 6;515(7525):112-5. doi: 10.1038/nature13666


Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission
BMC Biol. 2014 Oct 14;12:84. doi: 10.1186/s12915-014-0084-2.


Holstein TW
The evolution of the Wnt pathway
Cold Spring Harb Perspect Biol. 2012 Jul;4:a007922. doi: 10.1101/cshperspect.a007922


Somorjai IM, Lohmann JU, Holstein TW, Zhao Z
Stem cells: a view from the roots
Biotechnol J. 2012 Jun; 7:704-22. doi: 10.1002/biot.201100349


Holstein TW, Watanabe H, Ozbek S
Signaling pathways and axis formation in the lower metazoa
Curr Top Dev Biol. 2011;97:137-77. doi: 10.1016/B978-0-12-385975-4.00012-7


Nakamura Y, Tsiairis CD, Ozbek S, Holstein TW
Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer
Proc Natl Acad Sci USA. 2011 May;108:9137-42. doi: 10.1073/pnas.1018109108


 

A02 Bruce Edgar

Xiang J, Bandura J, Zhang P, Jin Y, Reuter H, Edgar BA
EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
Nat Commun. 2017 May;8:15125. doi: 10.1038/ncomms15125


Jin Y, Patel P, Kohlmaier A, Pavlovic B, Zhang C, Edgar BA
Intestinal stem cell pool regulation in Drosophila
Stem Cell Reports. 2017 Jun;8:1479-1487. doi: 10.1016/j.stemcr.2017.04.002


Zhou J, Edgar BA, Boutros M
ATF3 acts as a rheostat to control JNK signaling during intestinal regeneration
Nature Commun 8:14289. 2017 Mar; doi:10.1038/ncomms14289


Jin Y, Ha N, Forés M, Xiang J, Gläßer C, Maldera J, Jiménez G, Edgar BA
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
PLoS Genet. 2015 Dec 18;11(12):e1005634. doi: 10.1371/journal.pgen.1005634


Patel PH, Dutta D, Edgar BA
Niche appropriation by Drosophila intestinal stem cell tumours
Nat Cell Biol. 2015 Sep;17(9):1182-92. doi: 10.1038/ncb3214


Dutta D, Buchon N, Xiang J, Edgar BA
Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations
Curr Protoc Stem Cell Biol. 2015 Aug 3;34:2F.2.1-14. doi: 10.1002/9780470151808.sc02f02s34


Dutta D, Dobson AJ, Houtz PL, Gläßer C, Revah J, Korzelius J, Patel PH, Edgar BA, Buchon N
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
Cell Rep. 2015 Jul 14;12(2):346-58. doi: 10.1016/j.celrep.2015.06.009


Zhou J, Florescu S, Boettcher AL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA, Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017


Kohlmaier A, Fassnacht CH, Reuter H, Begum J, Jin Y, Dutta D, Edgar BA
Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine
Oncogene 34:2371-84 PMID: 24975577; Apr 2015; doi:10.1038/onc.2014.163


Korzelius J, Naumann SK, Loza-Coll MA, Chan JS, Dutta D, Oberheim J, Gläßer C, Southall TD, Brand AH, Jones DL, Edgar BA
Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells
EMBO J. 2014 Dec ;33:2967-82. doi: 10.15252/embj.201489072


 

A03 Joachim Wittbrodt

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug; 45:28-33. doi: 10.1016/j.gde.2017.02.002


Gutierrez-Triana JA, Mateo JL, Ibberson D, Ryu S,Wittbrodt J
iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins
Development. 143, 4272–4278; 2016 Nov 15. doi: 10.1242/dev.139261


Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development.143, 3470–3480; 2016 Oct 1. DOI: 10.1242/dev.134098


Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706


Stemmer M, Schuhmacher LN, Foulkes NS, Bertolucci C, Wittbrodt J
Cavefish eye loss in response to an early block in retinal differentiation progression
Development. 2015 Feb 15;142(4):743-52. doi: 10.1242/dev.114629


Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
PLoS One. 2015 Apr 24;10: e0124633. doi: 10.1371/journal.pone.0124633


Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892


Sinn R, Peravali R, Heermann S, Wittbrodt J
Differential responsiveness of distinct retinal domains to Atoh7
Mech Dev. 2014 Aug;133:218-29. doi: 10.1016/j.mod.2014.08.002


Centanin L, Wittbrodt J
Retinal neurogenesis
Development. 2014 Jan;141:241-4. doi: 10.1242/dev.083642


 

A06 Michael Boutros

Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan;10. pii: eaah6829. doi: 10.1126/scisignal.aah6829


Zhou J, Edgar BA and Boutros M
ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration
Nat Commun. 2017; 8: 14289. online 2017 Mar 8. doi: 10.1038/ncomms14289


Augustin I, Dewi DL, Hundshammer J, Erdmann G, Kerr G, Boutros M
Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells
Sci Signal. 2017 Jan 10;10(461). pii: eaah6829. doi: 10.1126/scisignal.aah6829


Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876


Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov. Doi: 10.1016/j.scr.2016.10.010


Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell 36, 79–93. 2016 Jan 11. doi: 10.1016/j.devcel.2015.12.015


Brunk F, Augustin I, Meister M, Boutros M, Kyewski B
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
J Immunol. 2015 Dec 1;195(11):5261-71. doi: 10.4049/jimmunol.1501265


Erdmann G, Suchanek M, Horn P, Graf F, Volz C, Horn T, Zhang X, Wagner W, Ho AD, Boutros M
Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
Genome Med. 2015 May 17;7(1):46. doi: 10.1186/s13073-015-0170-2


Zhou J, Florescu S, Boettcher A-LL, Luo L, Dutta D, Kerr G, Cai Y, Edgar BA and Boutros M
Dpp/Gbb signaling is required for normal intestinal regeneration during infection
Dev Biol. 2015 Mar 15;399(2):189-203. doi: 10.1016/j.ydbio.2014.12.017


 

A11 Lázaro Centanin

Seleit A, Krämer I, Riebesehl B, Ambrosio EA, Stolper J, Dross N, Lischik C, Centanin L
Neural stem cells induce the formation of their physical niche during organogenesis
Elife. 2017 Sep;6. pii: e29173. doi: 10.7554/eLife.29173


Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development 144, 687–697. 2017 Feb15 doi: 10.1242/dev.142752


Aghaallaei N, Gruhl F, Schaefer CQ, Wernet T, Weinhardt V, Centanin L, Loosli F, Baumbach T, Wittbrodt J
Identification, visualization and clonal analysis of intestinal stem cells in fish
Development.143, 3470–3480; 2016 Oct 1. DOI: 10.1242/dev.134098


Lust K, Sinn R, Pérez Saturnino A, Centanin L, Wittbrodt J
De novo neurogenesis by targeted expression of atoh7 to Müller glia cells
Development. 2016 Jun ;143:1874-83. doi: 10.1242/dev.135905


Reinhardt R, Centanin L, Tavhelidse T, Inoue D, Wittbrodt B, Concordet JP, Martinez-Morales JR, Wittbrodt J
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo
EMBO J. 2015 Jun 3;34(11):1572-88. doi: 10.15252/embj.201490706


Centanin L, Ander JJ, Hoeckendorf B, Lust K, Kellner T, Kraemer I, Urbany C, Hasel E, Harris WA, Simons BD, Wittbrodt J
Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
Development. 2014 Sep;141(18):3472-82. doi: 10.1242/dev.109892


 

A12 Claudia Scholl, Hanno Glimm

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007


Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels resembling IDHmut-driven DNA hypermethylation in AML stem cells
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294


Giessler KM, Kleinheinz K, Huebschmann D, Balasubramanian GP, Dubash TD, Dieter SM, Siegl C, Herbst F, Weber S, Hoffmann CM, Fronza R, Buchhalter I, Paramasivam N, Eils R, Schmidt M, von Kalle C, Schneider M, Ulrich A, Scholl C, Fröhling S, Weichert W, Brors B, Schlesner M, Ball CR, Glimm H
Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
J Exp Med. 2017 Jul 3;214(7):2073-2088. doi: 10.1084/jem.20162017


Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J, Glimm H
Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts
EMBO Mol Med. 2017 Jul;9(7):918-932. doi: 10.15252/emmm.201607354


Rouhi A, Miller C, Grasedieck S, Reinhart S, Stolze B, Döhner H, Kuchenbauer F, Bullinger L, Fröhling S, Scholl C
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells
Oncotarget. 2017 Jan;8:7678-7690. doi: 10.18632/oncotarget.13841


Uras IZ, Walter GJ, Scheicher R, Bellutti F, Prchal-Murphy M, Tigan AS, Valent P, Heidel FH, Kubicek S, Scholl C, Fröhling S, Sexl V
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Blood. 2016 Jun 9. doi: 10.1182/blood-2015-11-683581


Dubash TD, Hoffmann CM, Oppel F, Giessler KM, Weber S, Dieter SM, Hüllein J, Zenz T, Herbst F, Scholl C, Weichert W, Werft W, Benner A, Schmidt M, Schneider M, Glimm H, Ball CR
Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells
Cancer Lett. 2016 Feb 28. 371, 326-33. doi: 10.1016/j.canlet.2015.11.037


Stolze B, Reinhart S, Bulllinger L, Fröhling S, Scholl C
Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines
Sci Rep. 2015 Feb;5:8535. doi: 10.1038/srep08535


Voloshanenko O, Erdmann G, Dubash TD, Augustin I, Metzig M, Moffa G, Hundsrucker C, Kerr G, Sandmann T, Anchang B, Demir K, Boehm C, Leible S, Ball CR, Glimm H, Spang R, Boutros M
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
Nat Commun. 2013;4:2610. doi: 10.1038/ncomms3610


Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S, Scholl C
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33
J Exp Med. 2012 Apr;209:697-711. doi: 10.1084/jem.20111910


Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C, Glimm H
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
Cell Stem Cell. 2011 Oct;9:357-65. doi: 10.1016/j.stem.2011.08.010.


 

A13 Christoph Lutz

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May. 102, 1567-1577. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Wang W, Bochtler T, Wuchter P, Manta L, He H, Eckstein V, Ho AD, Lutz C
Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
Eur J Haematol. 2017 Nov;99:392-398. doi: 10.1111/ejh.12934


Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. 19: 271-281. doi: 10.1038/ncb3493


Wang W, Foerner E, Buss E, Jauch A, Eckstein V, Wuchter P, Ho AD, Lutz C
Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients
Leuk Lymphoma. 2016 Oct 13:1-9. DOI: 10.1080/10428194.2016.1236378.


Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct. 11, 51. DOI: 10.1186/s13062-016-0154-1


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


 

A14 Gislene Pereira

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007


Caydasi AK, Khmelinskii A, Duenas-Sanchez R, Kurtulmus B, Knop M, Pereira G
Temporal and compartment-specific signals coordinate mitotic exit with spindle position
Nat Commun. 2017 Jan. 8, 14129. doi: 10.1038/ncomms14129


Maekawa H, Neuner A, Rüthnick D, Schiebel E, Pereira G, Kaneko Y
Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha
Elife. 2017 Aug;6. pii: e24340. doi: 10.7554/eLife.24340


Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, Martin-Villalba A, Pereira, G
The leucine-rich repeat protein LRRC45 indicates modular functions of distal appendages in ciliogenesis
BioRxiv, 205625; doi: https://doi.org/10.1101/205625


Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713


Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033


Klinger M, Wang W, Kuhns S, Barenz F, Drager-Meurer S, Pereira G, Gruss OJ
The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
Mol Biol Cell. 2014 Feb;25:495-507. doi: 10.1091/mbc.E13-09-0526


Schmidt KN, Kuhns S, Neuner A, Hub B, Zentgraf H, Pereira G
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
J Cell Biol. 2012 Dec;199:1083-101. doi: 10.1083/jcb.201202126


 

A16 Gergana Dobreva

Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T
Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice
J Clin Invest. 2017 Jun;127:2235-2248. doi: 10.1172/JCI88725


Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G
Isl2b regulates anterior second heart field development in zebrafish
Sci Rep. 2017 Jan; 7: 41043.doi: 10.1038/srep41043


Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors
Cell Stem Cell. 2015 Sep;17:287-99. doi: 10.1016/j.stem.2015.08.007


Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A
Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity
Stem Cells. 2015 Apr;33: 1113-29. doi: 10.1002/stem.1923


Cheedipudi S, Genolet O, Dobreva G
Epigenetic inheritance of cell fates during embryonic development.
Front Genet. 2014 Feb; 5: 19. doi: 10.3389/fgene.2014.00019


Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S
Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.
Circ Res. 2013 Sep ;113:856-62. doi: 10.1161/CIRCRESAHA.113.302035


Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G
The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity
Dev Cell. 2012 Jul;23:58-70. doi: 10.1016/j.devcel.2012.06.005


Kieslinger M, Hiechinger S, Dobreva G, Consalez GG, Grosschedl R
Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
Cell Stem Cell. 2010 Oct;7:496-507. doi: 10.1016/j.stem.2010.07.015


 

A17 Henrik Kaessmann

Guschanski K, Warnefors M, Kaessmann H
The evolution of duplicate gene expression in mammalian organs
Genome Res. 2017 Sep;27:1461-1474. doi: 10.1101/gr.215566.116


Carelli FN, Hayakawa T, Go Y, Imai H, Warnefors M, Kaessmann H
The life history of retrocopies illuminates the evolution of new mammalian genes
Genome Res. 2016 Mar;26:301-14. doi: 10.1101/gr.198473.115


Necsulea A, Kaessmann H
Evolutionary dynamics of coding and noncoding transcriptomes
Nat Rev Genet. 2014 Nov;15:734-48. doi: 10.1038/nrg3802


Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F, Kaessmann H
The evolution of lncRNA repertoires and expression patterns in tetrapods
Nature. 2014 Jan;505:635-40. doi: 10.1038/nature12943


Cortez D, Marin R, Toledo-Flores D, Froidevaux L, Liechti A, Waters PD, Grützner F, Kaessmann H
Origins and functional evolution of Y chromosomes across mammals
Nature. 2014 Apr;508:488-93. doi: 10.1038/nature13151


Soumillon M, Necsulea A, Weier M, Brawand D, Zhang X, Gu H, Barthès P, Kokkinaki M, Nef S, Gnirke A, Dym M, de Massy B, Mikkelsen TS, Kaessmann H
Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
Cell Rep. 2013 Jun;3:2179-90. doi: 10.1016/j.celrep.2013.05.031


Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H
Birth and expression evolution of mammalian microRNA genes
Genome Res. 2013 Jan;23:34-45. doi: 10.1101/gr.140269.112


Julien P, Brawand D, Soumillon M, Necsulea A, Liechti A, Schütz F, Daish T, Grützner F, Kaessmann H
Mechanisms and evolutionary patterns of mammalian and avian dosage compensation
PLoS Biol. 2012 May;10:e1001328. doi: 10.1371/journal.pbio.1001328


Brawand D, Soumillon M, Necsulea A, Julien P, Csárdi G, Harrigan P, Weier M, Liechti A, Aximu-Petri A, Kircher M, Albert FW, Zeller U, Khaitovich P, Grützner F, Bergmann S, Nielsen R, Pääbo S, Kaessmann, H
The evolution of gene expression levels in mammalian organs
Nature. 2011 Oct;478:343-8. doi: 10.1038/nature10532


Kaessmann H
Origins, evolution and phenotypic impact of new genes
Genome Res. 2010 Oct;20:1313-26. doi: 10.1101/gr.101386.109


 

B01 Jan Lohmann

Schuerholz AK, Lopez-Salmeron V, Li Z, Forner J, Wenzl C, Gaillochet C, Augustin S, Vilches Barro A, Fuchs M, Gebert M, Vermeer JEM, Lohmann JU, Greb T, Wolf S
A Comprehensive Tool Set for Inducible, Cell Type-Specific Gene Expression in Arabidopsis
BioRxiv doi: https://doi.org/10.1101/242347


Gaillochet C, Jamge S, van der Wal F, Angenent G, Immink R, Lohmann JU
A molecular framework for functional versatility of HECATE transcription factors
BioRxiv doi: https://doi.org/10.1101/253815


Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876


Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Pfeiffer A, Miotk A, Hakenjos J, Forner J, Yanofsky MF, Marciniack-Czochra A, Lohmann JU
Control of plant cell fate transitions by transcriptional and hormonal signals
Elife. 2017 Oct;6. pii: e30135. doi: 10.7554/eLife.30135


Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 26, R816-R821. 2016 Sep. doi: 10.1016/j.cub.2016.07.070


Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023


Schuster C, Gaillochet C, Lohmann JU
Arabidopsis HECATE genes function in phytohormone control during gynoecium development
Development. 2015 Oct;142:3343-50. doi: 10.1242/dev.120444


Gaillochet C, Lohmann JU
The never-ending story: from pluripotency to plant developmental plasticity
Development. 2015 Jul;142:2237-49. doi: 10.1242/dev.117614


Forner J, Pfeiffer A, Langenecker T, Manavella P, Lohmann JU
Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases
PLoS One. 2015 Mar 30;10(3):e0121056. doi: 10.1371/journal.pone.0121056


Gaillochet C, Daum G, Lohmann JU
O cell, where art thou? The mechanisms of shoot meristem patterning
Curr Opin Plant Biol. 2015 Feb;23:91-7. doi: 10.1016/j.pbi.2014.11.002


Yang H, von der Fecht-Bartenbach J, Friml J, Lohmann JU, Neuhäuser B and Ludewig U
Auxin-modulated root growth inhibition in Arabidopsis thaliana seedlings with ammonium as the sole nitrogen source
Functional Plant Biology 42(3) 239-251 DOI: 10.1071/FP14171. Published: 24 October 2014


Daum G, Medzihradszky A, Suzaki T, Lohmann JU
A mechanistic framework for noncell autonomous stem cell induction in Arabidopsis
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14619-24. doi: 10.1073/pnas.1406446111


Vilarrasa-Blasi J, González-García MP, Frigola D, Fàbregas N, Alexiou KG, López-Bigas N, Rivas S, Jauneau A, Lohmann JU, Benfey PN, Ibañes M, Caño-Delgado AI
Regulation of plant stem cell quiescence by a brassinosteroid signaling module
Dev Cell. 2014 Jul 14;30(1):36-47. doi: 10.1016/j.devcel.2014.05.020


Schuster C, Gaillochet C, Medzihradszky A, Busch W, Daum G, Krebs M, Kehle A, Lohmann JU
A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals
Dev Cell. 2014 Feb;28:438-49. doi: 10.1016/j.devcel.2014.01.013


Lampropoulos A, Sutikovic Z, Wenzl C, Lohmann JU, Forner J
GreenGate - a novel, versatile, and efficient cloning system for plant transgenesis
PLoS One. 2013 Dec;8:e83043. doi: 10.1371/journal.pone.0083043


 

B02 Ingrid Lohmann

Trost N, Rempel E, Ermakova O, Tamirisa S, Parcalabescu L, Boutros M, Lohmann JU, Lohmann I
WEADE: a workflow for enrichment analysis and data exploration
BioRxiv doi: https://doi.org/10.1101/252924


Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007


Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876


Domsch K, Papagiannouli F, Lohmann I
The HOX-Apoptosis Regulatory Interplay in Development and Disease
Curr Top Dev Biol. 2015;114:121-58. doi: 10.1016/bs.ctdb.2015.07.014


Schardt L, Ander JJ, Lohmann I, Papagiannouli F
Stage-specific control of niche positioning and integrity in the Drosophila testis
Mech Dev. 2015 Nov; 3:336-348. doi: 10.1016/j.mod.2015.07.009


Papagiannouli F, Lohmann I
Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B
Comput Struct Biotechnol J. 2015 Jan; 13:122-130. doi: 10.1016/j.csbj.2015.01.001


Papagiannouli F, Lohmann I
The Male Stem Cell Niche: insights from Drosophila and mammalian model systems, Tissue Specific Stem Cell Niche (“Stem Cell Biology and Regenerative Medicine” Series), Dr. Kursad Turksen (Ed.)
ISSN: 2196-8985, Springer Verlag (accepted; in print) (www.springer.com/series/7896?detailsPage=titles)


Papagiannouli F, Schardt L, Grajcarek J, Ha N, Lohmann I
The Hox gene Abd-B controls stem cell niche function in the Drosophila testis
Dev Cell. 2014 Jan; 28(2):189-202. doi: 10.1016/j.devcel.2013.12.016.


Papagiannouli F, Lohmann I
Shaping the niche: lessons from the Drosophila testis and other model systems
Biotechnol J. 2012 Jun. doi: 10.1002/biot.201100352


 

B03 Christof Niehrs

Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C
Angiopoietin-like 4 Is a WNT Signaling Antagonist that Promotes LRP6 Turnover
Dev Cell. 2017 Oct;43:71-82.e6. doi: 10.1016/j.devcel.2017.09.011.


Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C
Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6
EMBO Rep. 2017 May; 18, 712-725. doi: 10.15252/embr.201643585


Acebron SP, Niehrs C
β-Catenin-Independent Roles of WNT/LRP6 Signaling
Trends Cell Biol. 2016 Dec;26:956-967. doi: 10.1016/j.tcb.2016.07.009


Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C
Post-transcriptional WNT Signaling Governs Epididymal Sperm Maturation
Cell. 2015 Nov;163:1225-1236. doi: 10.1016/j.cell.2015.10.029


Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C
Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112


Perez-Acebron SP, Karaulanov E, Berger BS, Huang YL, Niehrs C
Mitotic wnt signaling promotes protein stabilization and regulates cell size
Mol Cell. 2014 May;54:663-74. doi: 10.1016/j.molcel.2014.04.014


Huang YL, Niehrs C
Polarized WNT Signaling Regulates Ectodermal Cell Fate in Xenopus
Dev Cell. 2014 Apr;29:250-7. doi: 10.1016/j.devcel.2014.03.015.


Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C
Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A
Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031


Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037


 

B04 Andreas Trumpp

Haas S, Trumpp A
An Intrinsic Interferon Program Protects Stem Cells from Viral Infection
Dev Cell. 2018 Feb;44:279-280. doi: 10.1016/j.devcel.2018.01.013


Blume R, Rempel E, Manta L, Saeed BR, Wang W, Raffel S, Ermakova O, Eckstein V, Benes V, Trumpp A, Ho AD, Lutz C
The molecular signature of AML with increased ALDH activity suggests a stem cell origin
Leuk Lymphoma. 2018 Jan 16:1-10. doi: 10.1080/10428194.2017.1422862


Milanovic M, Fan DNY, Belenki D, Däbritz JHM, Zhao Z, Yu Y, Dörr JR, Dimitrova L, Lenze D, Monteiro Barbosa IA, Mendoza-Parra MA, Kanashova T, Metzner M, Pardon K, Reimann M, Trumpp A, Dörken B, Zuber J, Gronemeyer H, Hummel M, Dittmar G, Lee S, Schmitt CA
Senescence-associated reprogramming promotes cancer stemness
Nature. 2018 Jan;553:96-100. doi: 10.1038/nature25167


Bahr C, Paleske Lv, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk A, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies
Nature 2018 Jan; 553:515–520. doi:10.1038/nature25193


Raffel S, Falcone M, Kneisel N, Hansson J, Wang W Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294


Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell. 2017 May 18;169(5):807-823.e19. doi: 10.1016/j.cell.2017.04.018


Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr. 19; 271-281. doi: 10.1038/ncb3493


Sommerkamp P. and Trumpp A
Metabolic cues for hematopoietic stem cells
Science 02 Dec 2016: Vol. 354, Issue 6316, pp. 1103-1104, DOI: 10.1126/science.aal3466


Kanatsu-Shinohara M, Tanaka T, Ogonuki N, Ogura A, Morimoto H, Cheng PF, Eisenmann RN, Trumpp A, Shinohara T
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal
Genes Dev. 2016 Dec 1. doi: 10.1101/gad.287045.116


Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
Blood. 2016 Sep 1;doi: 10.1182/blood-2015-11-679167


Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033


Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J
Selection and dynamics of embryonic stem cell integration into early mouse embryos
Development. 2016 Jan 1;143(1):24-34. doi: 10.1242/dev.124602


Morrison G, Scognamiglio R, Trumpp A, Smith A
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification
EMBO J. 2016 Jan 1;35(3):356-68. doi: 10.15252/embj.201592116


Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors
Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013


Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition
Aging (Albany NY). 2015 Nov;7(11):911-27


Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors
Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MAG, Williams DA, Trumpp A and Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131


Höfner T, Eisen C, Klein C, Rigo-Watermeier T, Goeppinger SM, Jauch A, Schoell B, Vogel V, Noll E,Weichert W,Baccelli I, Schillert A, Wagner S, Pahernik S, Sprick MR and Trumpp A
Defined Conditions for the Isolation and Expansion of Basal Prostate Progenitor Cells of Mouse and Human Origin
Stem Cell Reports. 2015 Mar 10;4(3):503-18. doi: 10.1016/j.stemcr.2015.01.015


Tesio M, Tang Y, Mudder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp, A
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway
J Exp Med. 2015 Apr;212:525-38. doi: 10.1084/jem.20141438


Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Brocks D, Gu L, Herrmann C, Haas S, Essers M, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome and DNA methylome analysis
Cell Stem Cell. 2014 Oct;15:507-522. doi: 10.1016/j.stem.2014.07.005


Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wunsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C
Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Cell Cycle. 2014;13:3476-87. doi: 10.4161/15384101.2014.973334


Klimmeck D, Cabezas-Wallscheid N, Reyes A, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A
Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment
Stem Cell Reports. 2014 Nov; 3: 858–875


Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C, Lier A, Eisen C, Nowak V, Zens B, Müdder K, Klein C, Obländer J, Fey, S, Vogler J, Fabarius A, Riedl E, Roehl H, Kohlmann A, Staller M, Haferlach C, Müller N, John T, Platzbecker U, Metzgeroth G, Hofmann WK, Trumpp A, Nowak D
Myelodysplastic cells in patients re-program mesenchymal stromal cells to establish a transplantable stem cell-niche disease unit
Cell Stem Cell. 2014 Jun;14:824-37. doi: 10.1016/j.stem.2014.02.014


 

B06 Hellmut Augustin

Augustin HG, Koh GY
Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology
Science. 2017 Aug 3. pii: eaal2379. doi: 10.1126/science.aal2379


Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG
Pericyte-expressed Tie2 controls angiogenesis and vessel maturation
Nat Commun. 2017 Jul 18;8:16106. doi: 10.1038/ncomms16106


Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG
Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin
EMBO Mol Med. 2017 Jun;9(6):741-749. doi: 10.15252/emmm.201607222


Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG
Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells
Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):495-505. doi: 10.1161/ATVBAHA.116.308455


Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation
Sci Signal. 2016 Apr; 9(425):ra42. doi: 10.1126/scisignal.aad3812


Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG
Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca2+/NFAT signaling
Dev Cell. 2016 Jan 11;36(1):79-93. doi: 10.1016/j.devcel.2015.12.015


Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Freire Valls A, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG
The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024


Korn C, Augustin HG
Mechanisms of Vessel Pruning and Regression
Dev Cell. 2015 Jul 6;34(1):5-17. doi: 10.1016/j.devcel.2015.06.004.


Mogler C, Wieland M, Kö&nig C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG
Hepatic stellate cell-expressed Endosialin balances fibrogenesis and hepatocyte proliferation during liver damage
EMBO Mol Med. 2015 Mar;7:332-8. doi: 10.15252/emmm.201404246


Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG
Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat
Science. 2014 Jan; 343:416-9. doi: 10.1126/science.1244880


Korn C, Scholz B, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I
Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis
Development. 2014 Apr;141:1757-66. doi: 10.1242/dev.104422


Srivastava K, Ju J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG
Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy limits metastatic growth
Cancer Cell. 2014 Dec; 26:880-895. doi: 10.1016/j.ccell.2014.11.005


 

B07 Motomu Tanaka, Sascha Dietrich

Monzel C, Becker AS, Saffrich R, Wuchter P, Eckstein V, Ho AD, Tanaka M
Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents
Sci Rep. 2018 Jan;8:1841. doi: 10.1038/s41598-018-19557-x


Dietrich S, Oles M, Sellner L, Anders S, Lu J, Velten B, Mock A, Oakes C, Sutton L, Young E, Rosenquist R, Rossi D, Zirlik K, Herling M, Nguyen-Khac F, Plass C, von Kalle C, Dürig J, Ringshausen I, Huber W, Zenz T
Drug Perturbation Based Stratification of Blood Cancer
J Clin Invest. 2018 Jan;128:427-445. doi: 10.1172/JCI93801


Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tönjes M, Erez A, Adler L, Jensen P, Scholl C, Fröhling S, Cocciardi S, Wuchter P, Thiede C, Flörcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A
BCAT1 restricts αKG levels resembling IDHmut-driven DNA hypermethylation in AML stem cells
Nature. 2017 Nov;551:384-388. doi: 10.1038/nature24294


Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May. 102, 1567-1577. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Wang W, Bochtler T, Wuchter P, Manta L, He H, Eckstein V, Ho AD, Lutz C
Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
Eur J Haematol. 2017 Nov;99:392-398. doi: 10.1111/ejh.12934


Hörnig M, Nakahata M, Linke P, Yamamoto A, Veschgini M, Kaufmann S, Takashima Y, Harada A, and Tanaka M
Dynamic Mechano-Regulation of Myoblast Cells on Supramolecular Hydrogels Cross-Linked by Reversible Host-Guest Interactions
Sci Rep. 2017 Aug 9;7(1):7660. doi: 10.1038/s41598-017-07934-x


Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress
Cell Death Dis. 2016 Nov 10. doi: 10.1038/cddis.2016.342


Wuchter P, Vetter M, Saffrich R, Diehlmann A, Bieback K, Ho AD, Horn P
Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells
Exp Hematol. 2016 Jun doi: 10.1016/j.exphem.2016.02.004


Frank V, Kaufmann S, Wright R, Horn P, Yoshikawa HY, Wuchter P, Madsen J, Lewis AL, Armes SP, Ho AD, Tanaka M
Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency
Sci Rep. 2016 Apr 15;6:24264. doi: 10.1038/srep24264.


Veschgini M, Gebert F, Khangai N, Ito H, Suzuki R, Holstein TW, Mae Y, Arai T, Tanaka M
Tracking mechanical and morphological dynamics of regenerating Hydra tissue fragments using a two fingered micro-robotic hand
Appl. Phys. Lett. 108, 103702 (2016); doi: 10.1063/1.4943402


Wuchter P, Saffrich R, Giselbrecht S, Nies C, Lorig H, Kolb S, Ho AD, Gottwald E
Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells
Cell Tissue Res. 2016 Jan 30. doi:10.1007/s00441-015-2348-8


Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP, Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b


Monzel C, Veschgini M, Madsen J, Lewis AL, Armes SP, Tanaka M
Fine Adjustment of Interfacial Potential between pH-Responsive Hydrogels and Cell-Sized Particles
Langmuir. 2015 Aug 11;31(31):8689-96. doi: 10.1021/acs.langmuir.5b01896


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD
Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells
Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370


Stiehl T, Baran N, Ho AD, Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508


Malcherek G, Jin N, Hückelhoven AG, Mani J, Wang L, Gern U, Diehlmann A, Wuchter P, Schmitt A, Chen B, Ho AD, Schmitt M
Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells
Leukemia. 2014 Dec;28(12):2388-94. doi: 10.1038/leu.2014.273


Wuchter P, Leinweber C, Saffrich R, Hanke M, Eckstein V, Ho AD, Grunze M, Rosenhahn A
Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells
Cell Tissue Res. 2014 Feb. doi: 10.1007/s00441-013-1759-7


Ludwig A, Saffrich R, Eckstein V, Bruckner T, Wagner W, Ho AD, Wuchter P
Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor
Cytotherapy. 2014 Jan doi: 10.1016/j.jcyt.2013.07.007


 

B08 Anna Marciniak- Czochra

Stiehl T, Ho AD, Marciniak-Czochra A
Mathematical modeling of the impact of cytokine response of acute myeloid leukemia cells on patient prognosis
Scientific Reports. 2018 Jan. 8: 2809; doi:10.1038/s41598-018-21115-4


Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A
Revealing age-related changes of adult hippocampal neurogenesis using mathematical models
Development. 2018 Jan;145(1). pii: dev153544. doi: 10.1242/dev.153544


Gaillochet C, Stiehl T, Wenzl C, Ripoll JJ, Bailey-Steinitz LJ, Pfeiffer A, Miotk A, Hakenjos J, Forner J, Yanofsky MF, Marciniack-Czochra A, Lohmann JU
Control of plant cell fate transitions by transcriptional and hormonal signals
Elife. 2017 Oct;6. pii: e30135. doi: 10.7554/eLife.30135


Stiehl T, Marciniak-Czochra A
Stem cell self-renewal in regeneration and cancer: Insights from mathematical modeling
Current Opinion in Systems Biology. 2017 Oct; 5:112-120. https://doi.org/10.1016/j.coisb.2017.09.006


Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May; 102, 1567-1577 pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Dev Cell. 2016 Nov 7. 39, 289-301.doi: 10.1016/j.devcel.2016.10.002


Busse JE, Gwiazda P, Marciniak-Czochra A
Mass concentration in a nonlocal model of clonal selection
J Math Biol. 2016 Mar; 73, 1001-33. doi: 10.1007/s00285-016-0979-3


Stiehl T, Lutz C, Marciniak-Czochra A
Emergence of heterogeneity in acute leukemias
Biol Direct. 2016 Oct;11:51. DOI: 10.1186/s13062-016-0154-1


Stiehl T, Baran N, Ho AD and Marciniak-Czochra A
Cell division patterns in acute myeloid leukemia stem-like cells determine clinical course: a model to predict patient survival
Cancer Res. 2015 Mar 15;75(6):940-9. doi: 10.1158/0008-5472.CAN-14-2508


Stiehl T, Baran N, Ho AD, Marciniak-Czochra A
Clonal selection and therapy resistance in acute leukemias: Mathematical modelling explains different proliferation patterns at diagnosis and relapse
J R Soc Interface. 2014 Mar;11:20140079. doi: 10.1098/rsif.2014.0079


Ziebell F, Martin-Villalba A, Marciniak-Czochra A
Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells
J R Soc Interface. 2014 Mar;11:20140144. doi: 10.1098/rsif.2014.0144


 

B09 Ana Martin- Villalba

Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A
Revealing age-related changes of adult hippocampal neurogenesis using mathematical models
Development. 2018 Jan;145(1). pii: dev153544. doi: 10.1242/dev.153544.


Baser A, Skabkin M, Martin-Villalba A
Neural Stem Cell Activation and the Role of Protein Synthesis
Brain Plasticity. 2017 Nov; 3(1):27-41. DOI: 10.3233/BPL-160038


Llorens-Bobadilla E, Martin-Villalba A
Adult NSC diversity and plasticity: the role of the niche
Curr Opin Neurobiol. 2016 Dec; 42, 68-74. doi: 10.1016/j.conb.2016.11.008


Bifari F, Decimo I, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P
Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Cell Stem Cell. 2016 Nov; 20, 1-14. doi: 10.1016/j.stem.2016.10.020


Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Dev Cell. 2016 Nov; 39, 289-301. doi: 10.1016/j.devcel.2016.10.002


Drachsler M, Kleber S, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
Cell Death Dis. 2016 Apr 28. doi: 10.1038/cddis.2016.102


Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
Cell Stem Cell. 2015 Sep; 17, 329-340 doi: 10.1016/j.stem.2015.07.002


Seib DR, Martin-Villalba A
Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Gerontology. 2015;61(4):327-35. doi: 10.1159/000368575. Issue release date: June 2015


Ziebell F, Martin-Villalba A, Marciniak-Czochra A
Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells
J R Soc Interface. 2014 Mar;11:20140144. doi: 10.1098/rsif.2014.0144


Seib DRM, Corsini NS, Ellwanger K, Plass C, Mateos A, Pitzer C, Niehrs C, Celikel T, Martin-Villalba A
Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline
Cell Stem Cell. 2013 Feb;12:204-14. doi: 10.1016/j.stem.2012.11.010


Corsini N, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cell Stem Cell. 2009 Aug;5:178-90. doi: 10.1016/j.stem.2009.05.004.


 

B11 Hans-Reimer Rodewald, Thomas Höfer

Ryl T, Kuchen EE, Bell E, Shao C, Flórez AF, Mönke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T
Cell-cycle position of single MYC-driven cancer cells dictates their susceptibility to a chemotherapeutic drug
Cell Syst. 2017 Sep; 5:237-250.e8. doi: 10.1016/j.cels.2017.07.005


Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Rode I, Klapproth K, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T, Rodewald HR
Polylox barcoding reveals hematopoietic stem cell fates realized in vivo
Nature. 2017 Aug;548:456-460. doi: 10.1038/nature23653.


Höfer T, Rodewald HR
Output without input: the lifelong productivity of hematopoietic stem cells
Curr Opin Cell Biol. 2016 Dec;43:69-77. doi: 10.1016/j.ceb.2016.08.003


Busch K, Rodewald HR
Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different
Curr Opin Hematol. 2016 Jul;23:295-303. doi: 10.1097/MOH.0000000000000250.


Höfer T, Barile M, Flossdorf M
Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system
Curr Opin Biotechnol. 2016 Jun;39:150-6. doi: 10.1016/j.copbio.2016.04.001


Klapproth K, Lasitschka F, Rodewald HR
Multilayered ancestry of arterial macrophages
Nat Immunol. 2016 Feb;17:117-8. doi: 10.1038/ni.3374.


Höfer T, Busch K, Klapproth K, Rodewald HR
Fate Mapping and Quantitation of Hematopoiesis In Vivo
Annu Rev Immunol. 2016 May; 34: 449–478. doi: 10.1146/annurev-immunol-032414-112019


Rode I, Martins VC, Küblbeck G, Maltry N, Tessmer C, Rodewald HR
Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
J Immunol. 2015 Dec 15;195(12):5678-87. doi: 10.4049/jimmunol.1502010


Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Freire Valls A, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG
The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells
Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024


Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T and Rodewald HR
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo
Nature. 2015 Feb 26;518(7540):542-6. doi: 10.1038/nature14242


Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F and Rodewald HR
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Nature. 2015 Feb 26;518(7540):547-51. doi: 10.1038/nature13989


 

B12 Thomas Greb

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T
Bifacial stem cell niches in fish and plants
Curr Opin Genet Dev. 2017 Aug;45:28-33. doi: 10.1016/j.gde.2017.02.002


Brackmann K, Qi J, Gebert M, Jouannet V, Qi J, Schlamp T, Grünwald K, Wallner ES, Novikova DD, Levitsky VG, Agusti J, Sanchez P, Lohmann J, Greb T
Spatial specificity of auxin responses coordinates wood formation
bioRxiv online May 27,2017. doi: https://doi.org/10.1101/142885


Greb T, Lohmann JU
Plant Stem Cells
Curr Biol. 2016 Sep; 26(17):R816-R821. doi: 10.1016/j.cub.2016.07.070.


Wallner ES, López-Salmerón V, Greb T
Strigolactone versus gibberellin signaling: reemerging concepts?
Planta. 2016 Jun. doi: 10.1007/s00425-016-2478-6


Gursanscky NR, Jouannet V, Grünwald K, Sanchez P, Laaber-Schwarz M, Greb T
MOL1 is required for cambium homeostasis in Arabidopsis
Plant J. 2016 May; 86(3):210–220. doi: 10.1111/tpj.13169


 

B13 Marieke Essers, Michael Milsom

Prendergast ÁM, Kuck A, van Essen M, Haas S, Blaszkiewicz S, Essers MA
IFNa-mediated remodeling of endothelial cells in the bone marrow niche
Haematologica. 2017 Mar; 102: 445–453. doi: 10.3324/haematol.2016.151209


p> Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann W-K, Ho AD, Huber W, Trumpp A, Essers MAG, Steinmetz LM
Human haematopoietic stem cell lineage commitment is a continuous process
Nat Cell Biol. 2017 Apr;19:271-281. doi: 10.1038/ncb3493


p> Hirche C, Frenz T, Haas S, Döring M, Borst K, Tegtmeyer P, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U
Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo
Cell Rep. 2017 Jun; 19:2345-2356. doi: 10.1016/j.celrep.2017.05.063


p> Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
Nature. 2015 Apr;520:549-52. doi: 10.1038/nature14131


p> Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA
Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors
Cell Stem Cell. 2015 Oct;17:422-34. doi: 10.1016/j.stem.2015.07.007


p> Kaschutnig P, Bogeska R, Walter D, Lier A, Huntscha S, Milsom MD
The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells
Cell Cycle. 2015 Jul;14:2734-42. doi: 10.1080/15384101.2015.1068474


p> Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis
Cell Stem Cell. 2014 Oct;15:507-522. doi: 10.1016/j.stem.2014.07.005


p> Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C
Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfate sequencing
Cell Cycle. 2014;13:3476-87. doi: 10.4161/15384101.2014.973334


p> Essers MAG, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A
IFNa activates dormant HSCs in vivo
Nature. 2009 Apr;458:904-8. doi: 10.1038/nature07815


 

B14 Carmen Ruiz de Almodóvar

Paredes I, Himmels P, Ruiz de Almodóvar C
Neurovascular Communication during CNS Development
Dev Cell. 2018 Apr;45:10-32. doi: 10.1016/j.devcel.2018.01.023


Wang X, Freire Valls A, Shermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C
YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis
Dev Cell. 2017 Sep;42:462-478.e7. doi: 10.1016/j.devcel.2017.08.002


Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A
CNS Macrophages Control Neurovascular Development via CD95L
Cell Rep. 2017 May;19:1378-1393. doi: 10.1016/j.celrep.2017.04.056


Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar;8:14583. doi: 10.1038/ncomms14583


Lange C, Storkebaum E, Ruiz de Almodóvar C, Dewerchin M, Carmeliet P
Vascular endothelial growth factor: a neurovascular target in neurological diseases
Nat Rev Neurol. 2016 Aug;12:439-54. doi: 10.1038/nrneurol.2016.88


 

Z02 Volker Eckstein, Carsten Müller-Tidow

Wang W, Stiehl T, Raffel S, Hoang VT, Hoffmann I, Poisa-Beiro L, Saeed BR, Blume R, Manta L, Eckstein V, Bochtler T, Wuchter P, Essers M, Jauch A, Trumpp A, Marciniak-Czochra A, Ho AD, Lutz C
Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia
Haematologica. 2017 May. 102, 1567-1577. pii: haematol.2016.163584. doi: 10.3324/haematol.2016.163584


Wang W, Bochtler T, Wuchter P, Manta L, He H, Eckstein V, Ho AD, Lutz C
Mesenchymal stromal cells contribute to quiescence of therapy resistant leukemic cells in acute myeloid leukemia
Eur J Haematol. 2017 Nov;99:392-398. doi: 10.1111/ejh.12934


Wang W, Foerner E, Buss E, Jauch A, Eckstein V, Wuchter P, Ho AD, Lutz C
Hematopoietic stem cells can be separated from leukemic cells in a subgroup of adult acute lymphoblastic leukemia patients
Leuk Lymphoma. 2017 Jun;58:1446-1454. doi: 10.1080/10428194.2016.1236378


Drachsler M, Kleber S, Mateos A, Volk K, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz C R, Mueller W, Synowitz M, Martin-Villalba A
CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
Cell Death Dis. 2016 Apr;7:e2209. doi: 10.1038/cddis.2016.102.


Hoang VT, Buss EC, Wang W, Hoffmann I, Raffel S, Zepeda-Moreno A, Baran N, Wuchter P, Eckstein V, Trumpp A, Jauch A, Ho AD, Lutz C
The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients
Int J Cancer. 2015 Aug 1;137(3):525-36. doi: 10.1002/ijc.29410


Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD
Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells
Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370


Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A
Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
Cell Stem Cell. 2015 Sep; 17, 329-340 doi: 10.1016/j.stem.2015.07.002


Petersen HO, Höger SK, Looso M, Lengfeld T, Kuhn A, Warnken U, Nishimiya-Fujisawa C, Schnölzer M, Krüger M, Özbek S, Simakov O and Holstein TW
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration
Mol Biol Evol. 2015 Aug;32(8):1928-47. doi: 10.1093/molbev/msv079


 

Z03 Ulrike Engel


Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C
Stk33 is required for spermatid differentiation and male fertility in mice
Dev Biol. 2018 Jan ;433: 84-93. doi: 10.1016/j.ydbio.2017.11.007


Beretta CA, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez-Triana JA, Paolini A, Poggi L, Falk J, Ryu S, Kapsimali M, Engel U, Carl M
Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting
Curr Biol. 2017 Jan;27:270-278. doi: 10.1016/j.cub.2016.11.038


Engel U
Four-Channel Super-Resolution Imaging by 3-D Structured Illumination
Methods Mol Biol. 2017;1663:79-94. doi: 10.1007/978-1-4939-7265-4_7


Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar; 8: 14583. doi: 10.1038/ncomms14583


Seleit A, Kramer I, Riebesehl BF, Ambrosio EM, Stolper JS, Lischik CQ, Dross N, Centanin L
Neural stem cells induce the formation of their physical niche during organogenesis
Elife. 2017 Sep;6. pii: e29173. doi: 10.7554/eLife.29173


Seleit A, Krämer I, Ambrosio E, Dross N, Engel U, Centanin L
Sequential organogenesis sets two parallel sensory lines in medaka
Development. 2017 Feb; 144: 687-697. doi: 10.1242/dev.142752


Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C
YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
Dev Cell. 2017 Sep;42:462-478.e7. doi: 10.1016/j.devcel.2017.08.002


Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
J Cell Sci. 2016 Feb 1;129(3):621-36. doi: 10.1242/jcs.179713


Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain
Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033


Inoue S, Frank V, Hörning M, Kaufmann S, Yoshikawa HY, Madsen JP, Lewis AL, Armes SP and Tanaka M
Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
Biomater Sci. 2015 Dec;3(12):1539-44. doi: 10.1039/c5bm00205b


Marx A, Godinez WJ, Tsimashchuk V, Bankhead P, Rohr K, Engel U
Xenopus cytoplasmic linker-associated protein 1 (XCLASP1) promotes axon elongation and advance of pioneer microtubules
Mol Biol Cell. 2013 May; 24: 1544–1558. doi: 10.1091/mbc.E12-08-0573


 

Z04 Jan Lohmann, Henrik Kaessmann


Blume R, Rempel E, Manta L, Saeed BR, Wang W, Raffel S, Ermakova O, Eckstein V, Benes V, Trumpp A, Ho AD, Lutz C
The molecular signature of AML with increased ALDH activity suggests a stem cell origin
Leuk Lymphoma. 2018 Jan 16:1-10. doi: 10.1080/10428194.2017.1422862


Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodóvar C
Motor neurons control blood vessel patterning in the developing spinal cord
Nat Commun. 2017 Mar; 8, 14583. doi: 10.1038/ncomms14583


Papagiannouli F, Tamirisa S, Rempel E, Ermakova O, Trost N, Zhou J, Mundorf J, Brunel S, Ruhland N, Boutros M, Lohmann JU, Lohmann I
Decoding the regulatory logic of the Drosophila male stem cell system
BioRxiv doi.org/10.1101/227876


Augustin I, Dewi DL, Hundshammer J, Rempel E, Brunk F, Boutros M
Immune cell recruitment in teratomas is impaired by increased Wnt secretion
Stem Cell Res. 2016 Nov; 17, 607-615. doi: 10.1016/j.scr.2016.10.010


Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, Lohmann JU
Integration of light and metabolic signals for stem cell activation at the shoot apical meristem
Elife. 2016 Jul 11. doi: 10.7554/eLife.17023



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