CRC 873Seminars

Research in Progress and Seminar Series

The SFB873 organizes two alternating series of monthly seminars for internal progress report (Research in Progress) and high-profile external speakers (Seminar Series) , respectively.
They are held every other Friday at noon, followed by a common lunch, to facilitate exchange of ideas and informal interactions among members of the SFB and the Heidelberg life-science community.

Research in Progress

12:00-13:00 Seminar Room ZMBH


15 JAN (A03)

05 FEB (A11)

04 MAR (B03)(A12)

08 APR (A01) (A14)

13 MAY (B07) (B08)

03 JUN (A02)

01 JUL (B01)

29 JUL (B04)

16 SEP (B11)

07 OCT (A06)

11 NOV (B03)

02 DEC (A12)


09 JAN Thomas Stiehl (B08) “Feedback Signal Myelodysplastic Syndromes - Insights from Mathematical Modeling”
Georgis Kalamakis (B09) “The aging subventricular zone”

06 FEB Cornelia Monzel (B07) “Molecular Cues controlling Hematopoietic Stem Cell Adhesion and Migration in Model Bone Marrow Niche”
Georgis Kalamakis (B09) “The aging subventricular zone”
Methods: Stephan Kirchmaier (A03) “(Sub)cloning, Methods+Tricks”

06 MAR Juan Luis Mateo Cerdan (A03) “Characterisation of the neural stem cell gene regulatory network”
Marc Thier (B04) “Rolling the Dice for pluripotency: Implication of small non-coding RNAs for iPSC induction”
Methods: Daniel Klimmeck (B04) “Proteome”

17 APR Beate Scholz (B06) "Endothelial RSPO3 controls vascular stability and pruning through non canonical WNT/Ca2+/NFAT signaling/quot;
Jinyi Xiang (A02) “Regulation of String during Drosophila intestinal stem cell proliferation”
Methods: Michael Gebert (B01) “INTACT”

08 MAY Anne Pfeiffer (B01) “The Arabidopsis TOR Kinase, an Integrator of Light Derived Signals that Controls Plant Stem Cell Activation”
Jun Zhou (A06) “ATF3 acts as a rheostat to control JNK signaling in intestinal regeneration and inflammation”
Methods: Mahak Singhal (B06) and Andrej Miotk (B01) “RNA-seq”

12 JUN Stefan Koch (B03) “Post-transcriptional Wnt signaling governs epididymal sperm maturation”
Katrin Busch (B11)“Fate Mapping of Hematopoietic Stem Cells in situ”
Methods: cancelled

10 JUL Isabel Krämer (A11) “Proliferative heterogeneities among stem cells in vivo”
Enric Llorens Bobadilla (B09) “Single cell transcriptomics reveals dormant neural stem cells that respond to brain injury”
Methods: Peer Wünsche (A12) “Lineage analysis 'barcoding'”

07 AUG Sebastian Sorge (B02) “Cooperation between Notch signaling and mitochondrial dysfunction drives overproliferation in Drosophila”
Bahtiyar Kurtulmus (A14) “Analysis of centrosome asymmetries in stem cells”
Methods: Mahak Singhal (B09) and Lisa Paleske (B04) “FACS”

18 SEP (B07) and Leila Martins (A12)
Methods: Maria de Sol (A11) “CRISPR / CAS”

02 OCT (A01) and Borhan Saeed (A13)
Methods: Andrej Miotk (B01), Nina Cabezas (B04) and Daniel Klimmeck (B04) “Data Mining”

13 NOV (B04) and (B06)
Methods: Nina Cabezas (B04) and Enric Llorens Bobadilla (B09) “Single-CellTechniques / Microfluidics”

04 DEC (A02) and (B01)
Methods: Florian Heigwer (A06) “CRISPR / CAS web tool”


10 JAN Shayda Hemmati (A07) “Identification of Key Regulations of Post-embryonic Hematopoiesis”
Beate Scholz (B06) “The role of Wnt signaling in the regulation of blood vessel remodeling”

07 FEB Simon Raffel (B04) “Protoemic and Transcriptomic Profiling of Acute Myeloid Leukemia Stem Cells”
Katharina Nöske (B10) “Asymmetic cell division in human epidermis”

07 MAR Fani Papagiannouli (B02) “Hox genes as micromanagers of the Drosphilia male stem cell niche”
Cristina Sirrenberg- Cruciat (B03) “Regulation of Casein kinase 1 by Wnt/beta-catenin signaling”

04 APR Robert Reinhard (A03) “Transkriptional control of stemness in the retina”
Thomas Stiehl (B08) “Impact of Leukemic Stem Cell Properties on Clinical Course and Patient Prognosis - Insights from Mathematical Modeling”

09 MAY Iris Augustin (A06) “Mouse embryonic stem cell need Wnts for survival and lieage differentiation”
Enric Llorens Bobadilla (B09) “Injury-induced fate plasticity in neural stem cells”

06 JUN Marta Galach (A08) “Efficient generation of early epithelial cells from hiPSCs”
Gabor Daum (B01) “Cell-to-cell movement of a stem cell inducing transcription factor in plants”

04 JUL Oleg Simakov (A01) “Genomic signatures and stem cells in hydra regeneration”
Simon Haas (B05) “Inflammation-driven fast-track differentiation of HSCs into the megakaryocytic lineage”

01 AUG Yinhua Jin (A02) “EGFR / RAS / MAPK Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua and its target, Pointed”
Alexandra Burk & Van Hoang (B07) “Quantifying Adhesion Mechanisms of Human Hematopoietic Stem and Progenitor Cell on In Vitro Bone Marrow Niche Models”

05 SEP Susanne Bartels (B06) “Angiopoietin-2 as therapeutic target for GvHD”
Nina Cabezas (B04) “Identification of Regulatory Networks in HSCs and their Immediate Progeny Via Integrated Proteome, Transcriptome and DNA Methylome Analysis”

10 OCT Fani Papagiannouli (B02) “Stage-specific control of niche architecture in the Drosophila testis by the posterior Hox gene Abd-B”
Arturo Gutierrez (A03) “Vertebrate retinal stem cells: Towards dissecting the genetic network mediated by Rx2 in Medaka”

07 NOV Sergio P. Acebron (B03) “WNT-dependent stabilization of proteins (WNT/STOP) in mitosis promotes growth and cell cycle progression”
Fabian Graf (A06) “Mesenchymal stem cells mediate prostate cancer cell migration via diffusible extracellular matrix proteins”

05 DEC Christian Wenzl (B01) “Using 3D-microscopy to study environmental impact on stem cell homeostasis in plants”
Frederik Ziebell (B08) “Mathematical Modelling of Neural Stem Cell Dynamics in the Adult Hippocampus”


11 JAN Devanjali Dutta (A02) “Transcriptome profiling of Drosophila intestinal cell populations by RNA Sequencing”
Susanne Bartels (B06) “Angiopoietin-2 is a facilitator of hematopoietic stem and progenitor mobilization”

01 FEB Matthias Bernhardt (A08) “Reprogramming of human melanoma cells towards induced pluripotency”
Damian Wollny (B09) “Homeostasis and Cancer Initiation in the Adult Pancreas”

01 MAR Melania Tesio (B04) “The deubiquitinase CYLD controls hematopoietic stem cells dormancy via the NEMO kinase”
Cristina Sirrenberg-Cruciat (B03) “RNA Helicase DDX3 is a Regulatory Subunit of Casein Kinase 1 in Wnt/beta-catenin Signaling”

05 APR Burkhard Höckendorf (A03) “A quantitative clonal analysis of the growing fish retina”
Frederik Ziebell (B08) “Mathematical modelling of adult neurogenesis”

03 MAY Fabian Graf (A06) “Mesenchymal stromal cells: Possible mediators of bone metastasis?”
Julieta Maldera (A02) “Identifying factors required for Drosophila intestinal stem cell response to tissue damage”

07 JUN Fani Papagiannouli (B2) “Hox genes as micromanagers of the Drosophila male stem cell niche”
Judith Schlupf (A09) “Expression anf function of the IGF family during extra-embryonic endoderm differentiation”

05 JUL Lionel Larribere (A08) “Human iPSCs-based model of Neurofibromatosis type I”
Daniel Espadinha (B5) “Targeting quiescent leukemic stem cells through a combined treatment strategy”

02 AUG Sergio Perez Acebron (B03) “Wnt-mediated stabilization of mitotic proteins regulates cell growth and proliferation”
Robert Hermann (B09) “Regulation of Neural Progenitor Proliferation by Ankhd1”

06 SEP Aine Prendergast (B05) “The stress response of the hematopoietic stemm cell niche”
Felix Oppel (A07) “Clonal Dynamics and Phenotypic Plasticity within the Pancreatic Tumor-Initiating Cell Compartment”

11 OCT Philipp Scholz (B10) “Stem Cells in Skin Wound Healing”
Lisa Dohrn (B04) “Defining a Long-Range Enhancer that regulates c-Myc in Hematopoietic Stem Cells”

08 NOV Joachim Forner (B01) “Counting the Number of Stem Cells in the Shoot Apical Meristem of Arabidopsis thaliana”
Monika Petersson (A02) “Delineating steps of tumor progression of intestinal stem cell-derived precursors in the adult fly”

06 DEC Hendrik Petersen (A01) “Head regeneration in Hydra: A Quantitative Proteomic and Phosphoproteomic Approach”
WenWen Wang (B07) “Clonal Heterogeneity in Leukemic and 'Pre-leukemic' in Stem Cells”


13 JAN Stefanie Thamm (B05) “LPS induced activation of hematopoietic stem cells”
Rainer Saffrich (B07) “MSC 3D culture systems as model of the hematopoietic stem cell niche”

03 FEB Enric Llorens (B09) “Induction of alternative fate choices in adult NSCs”

02 MAR Robert Reinhard (A03) “Deciphering the retinal stem cell-specific gene regulatory network in O.latipes”

30 MAR Shayda Hemmati (A07) “Control of Stem Cell Fate by Key Regulators of Post-embryonic Hematopoiesis”
Thomas Stiehl (B08) “Can Mathematical Models Help to Understand Qualitative Behaviour of Leukemia Initiating Cells?”

04 MAY Hind Medyouf (B04) “Chracterization of malignant hematopoietic stem cells from patients with myelodysplastic syndrome (MDS) in a xenograft model”
Joachim Forner (B01) “Counting the Number of Stem Cells in Shoot Apical Meristem of Arabidopsis thaliana”

01 JUN Michael Suchanek (A06) “Screening in primary human mesenchymal stem cells”
Lionel Larribere (A08) “Diffentiation of human iPS cells into melancytes”

06 JUL Armin Ehninger (B04) “The role of SPARC and Tenascin C in HSC seeding, engraftment and hemotopoietic regeneration”
Jerome Korzelius (A02) “Studying the dynamics of Rbf/dE2F transcriptional regulation in the Drosophila midgut by tissue-specific ChIP-Seq”

03 AUG Elisa Specker (B10) “The Epidermal Stem Cell - A new approach to identify stem cells a viable label-retaining cells”
Eva-Maria Hartinger (A07) “Proliferative and Cell Cycle Activity of Transplantable Colon Cancer Initiaating Cells”

07 SEP Moritz Drachsler (B09) “The role of CD95 in Glioblastoma initiation”
Hanna Uckelmann (B05) “The role of Sca-1 in IFNalpha induced activation of HSCs”

05 OCT Iris Augustin (A06) and Anna Medzihradzky (B01)

09 NOV Katrin Schrenk-Siemens (B07) “hES cell-derived neural crest cells: a tool to study epithelial-mesenchymal transition (EMT)”
Larissa Carnevalli (B04) “Role of Granzyme B in hematpoietic stem cell homeostasis and activation”

07 DEC Isabel Hofmann (B07) “Shear stress regulates adhesion and rolling of CD44+ leikemic and hematopoietic progenitor cells on hyluronic acid”
Leonard Nevaril (B10) “The role of stroma for long-term epidermal regeneration”


04 FEB Patrick Wuchter (B07) and Zhong Zao (B01) and Alexander Kohlmaier (A02)

04 MAR Stephan Wurzer (B05) and Desiree Glagow (B09) and Susanne Bartels (B06)

01 APR Fani Papagianoulli (B02) and Thomas Stiehl (B08) and Berit Falkowska-Hansen (B10)

06 MAY Daniel Nowak (A08) and Eike Buss (B07) and Lazaro Centanin (A03)

03 JUN Judith Schlupf (A09) and Gerit Erdmann (A06) and Robert Hermann (B09)

01 JUL Christopher Hoffmann (A07) and Melania Tesio (B04) and Andrey Glinka (B03)

05 AUG Daniel Klimmeck (B04) and Friederike Herbst (A07) and Parthive Patel (A02)

07 OCT Roberta Scognamiglio (B04) and Claudia Korn (B06)

04 NOV Jinyi Xiang (A02) and Ines Brückmann (B04) and Christian Volz (A06)

02 DEC Marta Galach (A08) and Thomas Kaindl (B07) and Andrej Miotk (B01)

Seminar Series

12:00-13:30 Seminar Room ZMBH


23 JAN Thomas Laux
Institute of Biology III, University of Freiburg, Freiburg, Germany
“Initiation of the embryo body axis in Arabidopsis thaliana”

20 FEB Colette Dehay
CNRS (Centre Nacional de la Recherche Scientifique), Department of Embryonic Stem Cell and Cortical Development, Bron Cedex, France
“A primate-specific cellular and molecular logic for OSVZ expansion”

20 MAR Steven Pollard
MRC Centre for Regenerative Medicine
The University of Edinburgh, Edinburgh, Great Britain
“Programming and reprogramming brain tumour stem cells”

24 APR Henrik Kaessmann
Center for Integrative Genomics, UNIL, Lausanne, Switzerland
“Functional evolution of mammalian genomes”

22 MAY Alexander Aulehla
EMBL, Heidelberg, Germany
“Self-organization of genetic oscillators during mouse embryo development”

26 JUN Heinrich Reichert
Biozentrum of the University of Basel, Switzerland
“From neural stem cell to brain tumor: a genetic analysis in Drosophila”

24 JUL Veronika Sexl
Institute of Pharmacology and Toxicology, University of Veterinary Medicine of Vienna, Austria
“CDK6: new story from an old kinase”

25 SEP Carien M. Niessen
Department of Dermatology and CECAD,
University of Cologne, Cologne, Germany

09 OCT Carmen Ruiz de Almodóvar
Heidelberg University,
Biochemistry Center (BZH), Heidelberg, Germany

16 OCT Bertie Göttgens
Cambridge University Department of Haematology, Cambridge Institute for Medical Research & Wellcome Trust and MRC Stem Cell Institute, Cambridge, UK

20 NOV Simón Méndez Ferrer
Fundación CNIC Carlos III - Centro Nacional de
Investigaciones Cardiovasculares, Madrid, Spain

18 DEC Michael Wegner
Institute of Biochemistry, Erlangen, Germany


24 JAN Dirk Strunk
Paracelsus Medical University Salzburg, Salzburg, Austria
“HuNiche: A novel humanized bone and marrow niche formation mouse model”

21 MAR Juan Manuel Encinas
Achucarro Basque Center for Neuroscience, Zamudio, Spain
“Reactive Neural Stem Cells and Impairment of Neurogenesis in the Adult Hippocampus”

25 APR Phil Jones
MRC Cancer Unit, University of Cambridge, Cambridge, UK
“How oncogenic mutation alters progenitor cell behaviour in squamous carcinogenesis”

23 MAY Gian-Paolo Dotto
University of Lausanne Epalinges, Lausanne, Switzerland
“Multifactorial Notch and ER control of field cancerization and squamous carcinoma development”

27 JUN Albrecht Müller,
Institut für medizinische Strahlenkunde und Zellforschung im ZEMM, Würzburg, Germany
“Getting to the root of Polycomb function in ESCs and HSCs”

19 SEP Heinrich Jasper ,
The Buck Institute for Research on Aging, Novato, CA, USA
“Stem cells and aging: lessons from Drosophila”

21 NOV András Simon
Karolinska Institutet, Stockholm, Sweden
“Salamandar regeneration: regulation and evolution”


18 JAN Magdalena Götz
Helmholtz Zentrum München, Munich, Germany
“A new source of Neural Stem Cells After Brain Injury”

15 FEB Michael A. Rieger
Loewe Center for Cell and Gene Therapy Frankfurt, University Hospital Frankfurt, Frankfurt, Germany
“Continous single cell observation of hematopoietic stem cell fate decisions”

15 MAR Marcos Vidal The Beatson Institute for Cancer Research, Glasgow, UK
“Intestinal Stem Cells in self-renewal, regeneration and tumorigenesis in Drosophila”

19 APR Axel Behrens
Cancer Research UK ,London, UK
“Stem Cell regulation and cancer”

17 MAY Dominique Bonnet
London Research Institute, London, UK
“New heterogeneity of Leukaemic stem cells: implications for therapy”

21 JUN Anne-Claude Gavin
EMBL, Heidelberg, Germany
“Systematic screen reveals new function for a family oxysterol-binding proteins”

20 SEP Allsion Bardin
BDD - Institut Curie, Paris, France
“Controls of tissue specific stem cells: from cell-cell signaling to chromatin remodeling”

18 OCT Catherin Niemann
CMMC at the University of Cologne, Cologne, Germany
“Molecular mechanisms in stem cell-driven skin tumor initiation”

22 NOV Cristiona lo Celso
Imperial College London, London, UK
“In vivo imaging of nomral and malignant hematopoiesis in mouse bone marrow”


20 JAN Leanne Jones
Salk Institute, San Diego, USA
“Mechanisms regulating maintenance of stem cells and the stem cell niche”

17 FEB Halyna Shcherbata
Max Planck Institute for biophysical Chemistry, Göttingen, Germany
“Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in Drosophila learning centers ”

16 MAR Owen Sansom
The Beatson Institute for Cancer Research, Glasgow, UK
“Investigating Wnt signalling, intestinal stem cells and cancer in vivo”

27 APR Rüdiger Simon
Heinrich Heine University Düsseldorf, Düsseldorf, Germany
“Stem cell regulation by peptides and receptors in plants”

25 MAY Hartmut Geiger
Ulm University, Department of Dermatology and Allergic Diseases, Ulm, Germany
“Hematopoietic stem cell rejuvenation, polarity and Cdc42”

15 JUN Joachim Wittbrodt
Centre for Organismal Studies (COS), Heidelberg, Germany
“The retinal stem cell niche and its regulatory features”

20 JUL Christoph Lutz
Heidelberg University Hospital, Heidelberg, Germany
“Phenotypic and Genetic Heterogeneity in Childhood Acute Lymphoblastic Leukaemia”

17 AUG Walter Birchmeier
Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany
“Wnt/?-catenin signaling in stem and cancer stem cells”

21 SEP Axel Behrens
London Research Institute, London, UK

19 OCT Petri Salven
University of Helsinki, Department of Pathology, Helsinki, Finland
"Adult vascular endothelial stem cells (VESCs)“

23 NOV Phillippe Jay
Institute for Functional Genomics, Montpellier, France
“Quiescent stem cells and the immortal:DNA strand in the intestinal epithelium: Rest in peace?”


21 JAN Hans- Reimer Rodewald
DKFZ, Cellular Immunology, Heidelberg, Germany
“Origin and Transformation of T-Cell Progenitors”

18 FEB Michael A. Milsom
DKFZ and HI-Stem GmbH, Heidelberg, Germany
“Lost in transplantation: Fanconi anemia as a model of defective hematopoietic stem cell maintenance”

18 MAR Karl Lenhard Rudolph
University of Ulm, Ulm, Germany
“Batf defines a differentiation checkpoint limiting hematopoietic stem cell self renewal in response to DNA damage”

20 MAY Takashi Hiiragi
MPI Münster and EMBL Heidelberg, Germany
“Stochastic processes in the developmentof pluripotency in vivo”

17 JUN Andreas Wodarz
University of Göttingen, Göttingen, Germany
“Molecular control of cell polarity in epithelia and stem cells”

15 JUL Lukas Sommer
University of Zürich, Zürich, Switzerland
“Neural Crest Stem Cells and Melanoma:a Likely Connection”

16 SEP Christian Buske
University of Ulm, Ulm, Germany
“Developmental genes in acute myeloid leukemia: lessons from mice”

21 OCT Robert Oostendorp
Klinikum rechts der Isar, München, Germany
“The intimate relationship between stem cells and their niche”

18 NOV Hitoshi Niwa
RIKEN Center for Developmental Biology, Minatojima Minamimachi Chuo-ku Kobe, Japan
“Molecular mechanism governing cellular pluripotency of mouse embryonic stem cells”