Platynereis worm SEM picture


Research Papers

Bezares-Calderón LA, Shahidi R, Jékely G. A ciliary photoreceptor-cell circuit mediates pressure response in marine zooplankton bioRxiv 2023.02.28.530398; https://doi.org/https://doi.org/10.1101/2023.02.28.530398 (preprint)

Verasztó C, Jasek S, Gühmann M, Shahidi R, Ueda N, Beard JD, Mendes S, Heinz K, Bezares-Calderón LA, Williams E, Jékely G. Whole-animal connectome and cell-type complement of the three-segmented Platynereis dumerilii larva. biorXiv (2020); https://doi.org/10.1101/2020.08.21.260984 (preprint)

Jasek S, Verasztó C, Brodrick E, Shahidi R, Kazimiers T, Kerbl A, Jékely G.. Desmosomal connectomics of all somatic muscles in an annelid larva. Elife. 2022 Dec 20;11:e71231. https://doi.org/10.7554/eLife.71231.

Yañez-Guerra LA, Thiel D, Jékely G. Pre-metazoan origin of neuropeptide signaling. Mol Biol Evol. (2022) msac051. https://doi.org/10.1093/molbev/msac051

Thiel D, Yañez Guerra L, Franz-Wachtel M, Hejnol A, Jékely G. Nemertean, brachiopod and phoronid neuropeptidomics reveals ancestral spiralian signalling systems. Mol Biol Evol. (2021) msab21. https://doi.org/10.1093/molbev/msab211

Benito Gutierrez E, Stemmer M, Rohr SD, Schumacher LN, Tang J, Marconi A, Jékely G, Arendt D. The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon. BMC Biol 19, 110 (2021). https://doi.org/10.1186/s12915-021-01045-w

Gintoli M, Mohanan S, Salter P, Williams EA, Beard JD, Jékely G, Corbett AD. Spinning Disk-Remote Focusing Microscopy. Biomed. Opt. Express 11(6), 2874-2888 (2020)

Quiroga Artigas G, Lapébie P, Leclère L, Bauknecht P, Uveira J, Chevalier S, Jékely G, Momose T, Houliston E. A G-protein-coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia. PLoS Biol. 2020 Mar 3;18(3):e3000614. https://doi.org/10.1371/journal.pbio.3000614.

Thiel D, Bauknecht P, Jékely G, Hejnol A. A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus. Frontiers in Zoology, 2019 Jul 10;16:28. https://doi.org/10.1186/s12983-019-0326-9

Bernardo-Garcia JF, Syed M, Jékely G*, Sprecher SG*. Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans. EvoDevo 2019; 10:4. https://doi.org/10.1186/s13227-019-0117-6.

Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G. Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance. eLife. 2018 Dec 14;7. pii: e36262. https://doi.org/10.7554/eLife.36262.

Chartier TF, Deschamps J, Duerichen W, Jékely G, Arendt D. Whole-head recording of chemosensory activity in the marine annelid Platynereis dumerilii. Open Biology, 2018, https://doi.org/10.1098/rsob.180139

Varoqueaux F, Williams EA, Grandemange S, Truscello L, Kamm K, Schierwater B, Jékely G*, Fasshauer D*. High cell diversity and complex peptidergic signalling underlie placozoan behaviour. Curr Biol. 2018 Nov 5;28(21):3495-3501.e2. https://doi.org/10.1016/j.cub.2018.08.067.

Verasztó, Gühmann M, Jia H, Rajan VBV, Bezares-Calderón LA, Lopez CP, Randel N, Shahidi R, Michiels NK, Yokoyama S, Tessmar-Raible K, Jékely G. Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton. eLife. 2018 May 29;7. pii: e36440. https://doi.org/10.7554/eLife.36440.

Schmidt A, Bauknecht P, Williams EA, Augustinowski K, Gründer S*, Jékely G*. Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis. FASEB J, 2018 Apr 24:fj201800274R. https://doi.org/10.1096/fj.201800274R.

Quiroga G, Lapébie P, Leclère L, Takeda N, Deguchi R, Jékely G, Momose T, Houliston E. A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia. eLife. 2018 Jan 5;7. pii: e29555. https://doi.org/10.7554/eLife.29555.

Williams EA, Verasztó C, Jasek S, Conzelmann M, Shahidi R, Bauknecht P, Jékely G. Synaptic and peptidergic connectome of a neurosecretory centre in the annelid brain. eLife 2017;6:e26349 https://doi.org/10.7554/eLife.26349

Thiel D, Bauknecht P, Jékely G, Hejnol A. An ancient FMRFamide-related peptide-receptor pair induces defense behavior in a brachiopod larva. Open Biol. 2017 Aug;7(8). pii: 170136. https://doi.org/10.1098/rsob.170136

Kerb A, Conzelmann M, Jékely G, Worsaae K. High diversity in neuropeptide immunoreactivity patterns among three closely related species of Dinophilidae (Annelida). J Comp Neurol. 2017 Jul 26. https://doi.org/10.1002/cne.24289.

Verasztó C, Ueda N, Bezares-Calderón LA, Panzera A, Williams EA, Shahidi R, Jékely G

Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva. eLife. 2017 May 16;6. pii: e26000. https://doi.org/10.7554/eLife.26000

Bauknecht P, Jékely G. Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in bilaterians. BMC Biology, 2017 Jan 30;15(1):6.

Shahidi R, Williams E, Conzelmann M, Asadulina A, Verasztó C, Jasek S, Bezares-Calderón LA, Jékely G. A Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes. eLife 2015;10.7554/eLife.11147.

Hanswillemenke A, Kuzdere T, Vogel P, Jékely G, Stafforst T. Site-directed RNA editing in vivo can be triggered by the light-driven assembly of an artificial riboprotein. J. Am. Chem. Soc., 2015 Nov 24; doi:10.1021/jacs.5b10216.

Gühmann M, Jia H, Randel R, Verasztó C, Bezares-Calderón LA, Michiels NK, Yokoyama S, Jékely G. Spectral tuning of phototaxis by a Go-opsin in the rhabdomeric eyes of Platynereis. Current Biology, 2015;25(17):2265-2271.

Asadulina A, Conzelmann M, Williams EA, Panzera A, Jékely G. Object-based representation and analysis of light and electron microscopic volume data using Blender. BMC Bioinformatics, 2015;16:229.

Bauknecht, P. Jékely, G. Large-scale combinatorial deorphanization of Platynereis neuropeptide GPCRs. Cell Reports, 2015;12(4):684-93.

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G. Inter-individual stereotypy of the Platynereis larval visual connectome. eLife. 2015;4. https://doi.org/10.7554/eLife.08069.

Williams EA, Conzelmann M, Jékely G. Myoinhibitory peptide regulates feeding in the marine annelid Platynereis. Frontiers in Zoology 2015, 12:1

Randel N, Asadulina A, Bezares-Calderón LA, Verasztó C, Williams EA, Conzelmann M, Shahidi R, Jékely G.Neuronal connectome of a sensory-motor circuit for visual navigation. eLife 2014;10.7554/eLife.02730

Conzelmann M, Williams EA, Krug K, Franz-Wachtel M, Boris Macek B, Jékely G. The neuropeptide complement of the marine annelid Platynereis dumerilii. BMC Genomics, 2013 Dec 20;14(1):906.

Doumpas N, Jékely G, Teleman AA. Wnt6 is required for maxillary palp formation in Drosophila. BMC Biology, 2013 Oct 3;11(1):104.

Randel N, Bezares L, Gühmann M, Shahidi R, Jékely G.Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae. Integrative & Comparative Biology, 2013 Jul;53(1):7-16.

Jékely G. Global view of the evolution and diversity of metazoan neuropeptide signaling. PNAS, 2013 May 21;110(21):8702-7.

Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G. Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. PNAS, 2013 May 14;110(20):8224-8229.

Holder T, Basquin C, Ebert J, Randel N, Jollivet D, Conti E, Jékely G*, Bono F*. Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability. Biology Direct, 2013, 8:2. *Co-corresponding

Asadulina A, Panzera A, Verasztó Cs, Liebig C, Jékely G. Whole-body gene expression pattern registration in Platynereis larvae. EvoDevo, 2012, 3:27.

Conzelmann M, Jékely G. Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox. EvoDevo, 2012 Oct 1;3(1):23.

Conzelmann M, Schilli S, Asadulina S, Keller T, Münch TA, Jékely G. Neuropeptides regulate swimming depth of Platynereis larvae. PNAS, 2011 Nov 15;108(46):E1174-83.

Jékely G*, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D*. Mechanism of phototaxis in marine zooplankton. Nature, 2008;456(7220):395-9.

Jékely G. Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell. Biology Direct, 2008;3:31.

Denes A*, Jékely G*, Steinmetz P, RaibleF, Snyman H, Prud’homme B, Ferrier D, Balavoine G, Arendt D.Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. Cell, 2007; 129(2):277-288.

Jékely G, Arendt D. Cellular resolution expression profiling using confocal detection of NBT-BCIP precipitate by reflection microscopy. BioTechniques, 2007; 42(6): 751-755.

Jékely G. Origin of phagotrophic eukaryotes as cheaters in microbial biofilms. Biology Direct, 2007;2(2):3

Jékely G, Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. BioEssays, 2006;28(2):191-8.

Jékely G, Sung H, Luque CM, Rørth P. Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration. Developmental Cell, 2005;9(2):197-207.

Jékely G, Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep, 2003;4(12):1163-8.

Jékely G. Small GTPases and the evolution of the eukaryotic cell. Bioessays, 2003;25(11):1129-38.

Farkas A, Tompa P, Schád E, Sinka R, Jékely G, Friedrich P. Autolytic activation and localization in Schneider cells (S2) of calpain B from Drosophila. Biochem J. 2004;378(Pt 2):299-305.

Schád E, Farkas A, Jékely G, Tompa P, Friedrich P. A novel human small subunit of calpains. Biochem J. 2002;362(Pt 2):383-8.

Duchek P, Somogyi K, Jékely G, Beccari S, Rørth P. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell, 2001;107(1):17-26.

Szabo K, Jékely G, Rørth P. Cloning and expression of sprint, a Drosophila homologue of RIN1. Mech Dev, 2001;101(1-2):259-62.

Jékely G, Pinter M, Friedrich P. Drosophila calpains. Purification of a calpain-like enzyme from fruit flies, and expression in Escherichia coli. Methods Mol Biol, 2000;144:67-74.

Jékely G, Friedrich P. Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB. J Biol Chem, 1999;274(34):23893-900.

Jékely G, Friedrich P. The evolution of the calpain family as reflected in paralogous chromosome regions. J Mol Evol, 1999;49(2):272-81.

Pintér M, Jékely G, Szepesi RJ, Farkas A, Theopold U, Meyer HE, Lindholm D, Nässel DR, Hultmark D, Friedrich P. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago. Insect Biochem Mol Biol. 1998;28(2):91-8.


Concept papers, reviews and dispatches

Gründer S, Ramírez AO, Jékely G. Neuropeptides and degenerin/epithelial Na+ channels: a relationship from mammals to cnidarians. J Physiol. 2022 Nov 22. https://doi.org/10.1113/JP282309.

Williams AE and Jékely G. Nervous systems: Neuropeptides define enigmatic comb-jelly neurons. Curr Biol. 2021 Dec 6;31(23):R1515-R1517.

Brodrick E and Jékely G. Flatworm behaviour: Pieces behaving like wholes. Curr Biol. 2021 Nov 22;31(22):R1472-R1474

Burkhardt P and Jékely G. Evolution of Synapses and Neurotransmitter Systems: the Divide-and-Conquer Model for Early Neural Cell-Type Evolution. Current Opinion in Neurobiology, Vol. 71, 2021 Dec, 127-138

Ozpolat D, Randel N, Williams EA, Bezares-Calderón LA, Andreatta G, Balavoine G, Bertucci PY, Ferrier DEK, Gambi MC, Gazave E, Handberg-Thorsager M, Hardege J, Hird C, Hsieh Y, Hui Y, Mutemi KN, Schneider SQ, Simakov O, Vergara HM, Vervoort M, Jékely G, Tessmar-Raible K, Raible F, Arendt D. The Nereid on the Rise: Platynereis as a Model System. Evodevo 2021 Sep 27;12(1):10.

Jékely G, Budd GE. Animal Phylogeny: Resolving the Slugfest of Ctenophores, Sponges and Acoels? Curr Biol. 2021 Feb 22;31(4):R202-R204.

Jékely G, Godfrey Smith P, Keijzer F. Reafference and the origin of the self in early nervous system evolution. Phil. Trans. R. Soc. B 20190764. 2021 https://doi.org/10.1098/rstb.2019.0764

Jékely G. The chemical brain hypothesis for the origin of nervous systems. Phil. Trans. R. Soc. B 2021, 20190761. https://doi.org/10.1098/rstb.2019.0761.

Jékely G, Wan KY. Origins of eukaryotic excitability. Phil. Trans. R. Soc. B 2021, 376: 20190758. https://doi.org/10.1098/rstb.2019.0758.

Marinković M, Berger J, Jékely G. Neuronal coordination of motile cilia in locomotion and feeding. Philos Trans R Soc Lond B Biol Sci, 2020 Feb 17;375(1792):20190165. https://doi.org/10.1098/rstb.2019.0165.

Bezares-Calderón LA, Berger J, Jékely G. Diversity of cilia-based mechanosensory systems and their functions in marine animal behaviour. Philos Trans R Soc Lond B Biol Sci, 2020 Feb 17;375(1792):20190376. https://doi.org/10.1098/rstb.2019.0376.

Wan KY, Jékely G. On the unity and diversity of cilia. Philos Trans R Soc Lond B Biol Sci. 2020 Feb 17;375(1792):20190148. https://doi.org/10.1098/rstb.2019.0148. (Editorial)

Jékely G. Evolution: How Not to Become an Animal. Curr Biol 2019; 29:1240-1242.

Jékely G, Arnone MI. Editorial overview: Tissue-level dynamics in development and evolution. Current Opinion in Genetics and Development 2019, 57, doi.org/10.1016/j.gde.2019.09.003

Buchholz TO, Krull A, Shahidi R, Pigino G, Jékely G, Jug F. Content-aware image restoration for electron microscopy. Methods in Cell Biology 2019; 152, 277-289.

Williams E and Jékely G. Neuronal cell types in the annelid Platynereis dumerilii. Current Opinion in Neurobiology. 2019 June 2019, 56;106-116.

Jékely G, Melzer S, Beets I, Grunwald Kadow IC, Koene J, Haddad S, Holden-Dye L. The long and the short of it: A perspective on peptidergic regulation of circuits and behaviour. J Exp Biol. 2018 Feb 8;221(Pt 3). pii: jeb166710.

Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R. Back to the Basics: Cnidarians Start to Fire. Trends Neurosci. 2016 Dec 29. pii: S0166-2236(16)30168-0.

Bezares-Calderón LA, Jékely G. Think small. eLife. 2016 Dec 6;5. pii: e22497.

Williams E, Jékely G. Towards a systems level understanding of development in the annelid Platynereis. Current Opinion in Genetics & Development, 2016 Aug 5;39:175-181.

Randel N, Jékely G. Phototaxis and the origin of visual eyes. Philos Trans R Soc Lond B Biol Sci, 2016 Jan 5;371(1685).

Jékely G, Keijzer F, Godfrey Smith P. An Option Space for Early Neural Evolution. Philos Trans R Soc Lond B Biol Sci, 2015 Dec 19;370(1684).

Jékely G, Jordi Paps J, Nielsen C. The phylogenetic position of ctenophores and the origin(s) of nervous systems. EvoDevo 2015, 6:1.

Jékely G. Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles. Cold Spring Harbor Perspectives, 2014, Sep 2;6(9).

Lapraz F, Rawlinson K, Girstmair J, Tomiczek B, Berger J, Jékely G, Telford M, Egger B. Put a tiger in your tank: the polyclad flatworm Maritigrella crozieri as a model for evodevo. EvoDevo, 2013 Oct 9;4(1):29.

Jékely G. Origin and early evolution of neural circuits for the control of ciliary locomotion. Proc Biol Sci. 2011;278:914-22.

Jékely G. Evolution of phototaxis. Philos Trans R Soc Lond B Biol Sci, 2009;364:2795-808.

Satir P, Mitchell DR, Jékely G. How did the cilium evolve? Current Topics in Dev Biol, 2008;85:63-82.

Arendt D, Denes AS, Jékely G, Tessmar-Raible K. The evolution of nervous system centralization. Philos Trans R Soc Lond B Biol Sci, 2008;363(1496):1523-8

Jékely G. Evolution of the Golgi complex. in The Golgi Apparatus editors: Mironov A, Pavelka M. 2008 SpringerWienNewYork

Jékely G. Origin of eukaryotic endomembranes: a critical evaluation of different model scenarios. Adv Exp Med Biol, 2007;607:38-51.

Jékely G. Did the last common ancestor have a biological membrane? Biology Direct, 2006;1(1):35

Fritzsch B, Piatigorsky J, Tessmar-Raible K, Jékely G, Guy K, Raible F, Wittbrodt J, Arendt D. Ancestry of Photic and Mechanic Sensation? Science, 2005;308(5725):1113-1114.

Jékely G. Glimpsing over the event horizon: evolution of nuclear pores and envelope. Cell Cycle, 2005;4(2):297-9.

Jékely G. Evolution in a nutshell. EMBL PhD student symposium on evolution. EMBO Rep, 2002;3(4):307-11.


Jékely G. The Story of Genetics, Development and Evolution: A Historical Dialogue
World Scientific Publishing, London, 2017; ISBN-13: 978-1786342539
First published in Hungarian, Kalligram: Bratislava 2006 ISBN 80-7149-844-0

Eukaryotic Membranes and Cytoskeleton: Origins and Evolution. Edited by Jékely G. Landes Bioscience 2007.