Modelling of Biological ProcessesDr. Nadine Veith

Current Research

  • investigation of metabolic pathways using ODE-based, dynamic models
  • reconstruction and analyses of microbial genome-scale metabolic models
  • using constraint- based modelling techniques



Anna Feldman-Salit*, Nadine Veith*, Markus Wirtz, Rüdiger Hell, Ursula Kummer. Distribution of control in the sulfur assimilation in Arabidopsis thaliana depends on environmental conditions. New Phytologist, 222(3):1392-1404. Doi: 10.1111/nph.15704.

*equal contribution


Luis Aguilera, Frank T. Bergmann, Giovanni Dalmasso, Sinan Elmas, tobias Elsässer, Ruth Grosseholz, Pascal Holzheu, Riyata Kalra, Ursula Kummer, Sven Sahle, Nadine Veith. Robustness of frequency vs. Amplitude coding of calcium oscillations during changing temperatures. Biophysical Chemistry, 245: 17-24, 2019. Doi: 10.1016/j.bpc.2018.11.003.


Ruth Grosseholz*, Ching-Chiek Koh*, Nadine Veith*, Tomas Fiedler, Madlen Strauss, Brett Olivier, Ben C Collins, Olga T Schubert, Frank Bergmann, Bernd Kreikemeyer, Ruedi Aebersold, and Ursula Kummer. Integrating highly quantitative proteomics and genome-scale metabolic modeling to study pH adaptation in the human pathogen Enterococcus faecalis. NPJ Systems Biology and Applications, 2:16017, 2016. doi:10.1038/npjsba.2016.17

*equal contribution


Jennifer Levering, Tomas Fiedler, Antje Sieg, Koen W A van Grinsven, Silvio Hering, Nadine Veith, Brett G Olivier, Lara Klett, Jeroen Hugenholtz, Bas Teusink, Bernd Kreikemeyer, Ursula Kummer. Genome-scale reconstruction of the Streptococcus pyogenes M49 metabolic network reveals growth requirements and indicates potential drug targets. Journal of Biotechnology, 23: 225-37, August 2016. doi: 10.1016/j.jbiotec.2016.01.035


Nadine Veith. Metabolic properties of the human pathogen Enterococcus faecalis V583 investigated by computational modelling. Dissertation. Ruprecht-Karls-Universität Heidelberg Nov. 2015.


Nadine Veith*, Margrete Solheim*, Koen W A van Grinsven, Brett G Olivier, Jennifer Levering, Ruth Grosseholz, Jeroen Hugenholtz, Helge Holo, Ingolf Nes, Bas Teusink, and Ursula Kummer. Using a Genome-Scale Metabolic Model of Enterococcus faecalis V583 to Assess Amino Acid Uptake and Its Impact on Central Metabolism. Applied and Environmental Microbiology, 81(5):1622-33, March 2015. doi: 10.1128/AEM.03279-14

*equal contribution


Nadine Veith, Anna Feldman-Salit, Vlad Cojocaru, Stefan Henrich, Ursula Kummer, and Rebecca C Wade. Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria. PloS Computational Biology, 9(7):e1003159, January 2013. doi: 10.1371/journal.pcbi.1003159


Anna Feldman-Salit, Silvio Hering, Hanan L Messiha, Nadine Veith, Vlad Cojocaru, Antje Sieg, Hans V Westerhoff, Bernd Kreikemeyer, Rebecca C Wade and Tomas Fiedler. Regulation of the activity of lactate dehydrogenase from four lactic acid bacteria. The Journal of Biological Chemistry, 288(29):21295-306, Juli 2013. doi: 10.1074/jbc.M113.458265