Holstein labProf. Suat Özbek
Our research is focused on structure/function relationships and the evolution of extracellular matrix and signaling molecules. In particular, we are interested in the evolution of complex features, as of organelles, and of early extracellular matrix. In our research we are applying biochemical, microscopic and structural techniques as well as systems biology approaches using functional genomics and proteomics.
Our model organism is the cnidarian Hydra, which represents one of the most basal metazoan animals. Hydra has been a model for cell biology and regeneration for decades and the availability of genome data and of transgenic animals has opened up new systematic and functional approaches. The simplicity, evolutionary impact and regenerative capacity of Hydra offer fundamental research possibilities with important implications for higher metazoans, including humans.
Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.
Tursch A, Mercadante D, Tennigkeit J, Gräter F and Özbek S.
Sci Rep. 2016 May 11; 6:25709.
The nematocyst: a molecular map of the cnidarian stinging organelle.
Beckmann A, Özbek S.
Int J Dev Biol. 2012 56(6-8):577-82.
Proteome of Hydra nematocyst.
Balasubramanian PG, Beckmann A, Warnken U, Schnölzer M, Schüler A, Bornberg-Bauer E, Holstein TW and Özbek S.
J Biol Chem. 2012 Mar 23;287(13):9672-81.
Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin.
Eriksson M, Hassan S, Larsson R, Linder S, Ramqvist T, Lövborg H, Vikinge T, Figgemeier E, Müller J, Stetefeld J, Dalianis T and Özbek S.
Anticancer Res. 2009 Jan;29(1):11-8.