Rüdiger Hell Publications
Since 2022
Sun, S., Hell, R., Wirtz, M. (2026) The chloroplast cysteine synthase complex in guard cells is critical for stress-induced stomatal closure. Plant Physiol. 201:kiag263. doi: 10.1093/plphys/kiag263.
Tremblay, B. J.-M., Adeel, S.A., Saechao, M. C., Dong, Y., Andrianasolo, E., Steele, J.M., Traa, A., Yogadasan, N., Waduwara-Jayabahu, I., Katzenback, B. A., Hell, R., Wirtz, M., Moffatt, B. A. (2026) Methylthioadenosine-driven rewiring of sulfur assimilation lowers the methyl index and fertility in Arabidopsis. J. Exp. Bot., erag135. doi: 10.1093/jxb/erag135
Sun, S., Hell, R., Wirtz, M. (2026) Emerging functions of cysteine synthase complexes in plants. J. Exp. Bot., erag115, doi: 10.1093/jxb/erag115
Sun, S., Hell, R., Wirtz, M. (2026) Tansley insight: Novel roles of sulfur metabolism in stress-controlled stomata aperture regulation. New Phytol. 250: 1460–1467. doi: 10.1111/nph.71048
Gong, X., Pożoga, M., Boyer, J.-B., Xue, X., Meinnel, T., Bange, T., Giglione, C., Hell, R., Wirtz, M. (2026) The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons. Nat. Comm., 31: 3116. doi: 10.1038/s41467-026-71208-2
Hankofer, V., Ghirardo, A., Obermaier, L., Poschet, G., Suresh Kumar, S., Gross, I., Durner, J., Rychlik, M., Wirtz, M., Hell, R., Schnitzler, J.-P., Groth, M. (2026) Photorespiration is linked to DNA methylation by formate as a one-carbon source. Nat. Plants 12: 653–664.https://doi.org/10.1038/s41477-026-02222-x
Sun, S.-K., Ahmad, N., Callenius, H., Rajab, H., Vural Uslu, V., Rey Cruz Cruz, J., Zhao, F.-J., Wirtz, M., Hell, R. (2025) The plastid cysteine synthase complex regulates ABA biosynthesis and stomatal closure in Arabidopsis. Nat. Commun. 16, Article nr.: 8960. doi: 10.1038/s41467-025-64705-3
Sulaj, A., Nguyen, P.B.H., Poschet, G., Kliemank, E., Fleming, T., Henke, L., Neibig, W., Kopf, S., Hell, R., Longo, V.D., Herzig, S., Nawroth, P.P., Menden, M.P., Szendroedi, J. (2025) Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes. Mol. Metab. 102 :102257. doi: 10.1016/j.molmet.2025.102257
Liu, H., Tang, Y., Singh, A., Vong, J., Cordero, J., Mathes, A., Gao, R., Jia, Y., Garvalov, B., Acker, T., Poschet, G, Hell, R., Schneider, M. A., Heineke, J., Wieland, T., Barreto, G., Cerwenka, A., Potente, M., Bibli, S.-I., Savai, R., Dobreva, G. (2025) RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α. Nat. Commun., 16:4929-4950. doi: 10.1038/s41467-025-60223-4
Xu, X., Sun, S.K., Gao, A., Huang, X.Y., Wirtz, M., Hell, R., Zhao, F.J. (2024) Biofortifying multiple micronutrients and decreasing arsenic accumulation in rice grain simultaneously by expressing a mutant allele of OAS-TL gene. New Phytol. 244: 2382-2395. doi: 10.1111/nph.20168.
Bröker-Lai, J., Terol, J. R., Richter, C., Mathar, I., Wirth, A., Kopf, S., Moreno-Pérez, A., Büttner, M., Tan, L. L., Makke, M., Poschet, G., Hermann, J., Tsvilovskyy, V., Haberkorn, U., Wartenberg, P., Susperreguy, S., Berlin, M., Ottenheijm, R., Philippaert, K., Wu, M., Wiedemann, T., Herzig, S., Belkacemi, A., Terral, R. L., Agarwal, N., Camacho Londoño, J. E., Klebl, B., Dinkel, K., Zufall, F., Nussbaumer, P., Boehm, U., Hell, R., Nawroth, P., Birnbaumer, L., Leinders-Zufall, T., Kuner, R., Zorn, M., Bruns, D., Schwarz, Y., Freichel, M. (2024) TRPC5 controls the adrenaline-1 mediated counter regulation of hypoglycemia. EMBO J. 43: 5813-5836. doi: 10.1038/s44318-024-00231-0
Gegner, H.M., Naake, T., Aljakouch, K., Dugourd, A., Kliewer, G., Müller, T., Schilling, D., Schneider, M.A., Kunze-Rohrbach, N., Grünewald, T.G.P., Hell, R., Saez-Rodriguez, J., Huber, W., Poschet, G., Krijgsveld, J. (2024) A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens. Clin. Proteomics 21: 4 9, 10.1186/s12014-024-09501-9
Armbruster, L., Pozoga, M., Wu, Z., Eirich, J., Thulasi, K., Kumar, D., de la Torre, C., Miklankova, P., Huber, M., Bradic, F., Poschet, G., Weidenhausen, J., Merker, S., Ruppert, T., Sticht, C., Sinning, I., Finkemeier, I., Li, X., Hell, R., Wirtz, M. (2024) The Nα-acetyltransferase NAA50 mediates plant immunity independent of the NatA complex. Plant Physiol., doi: 10.1093/plphys/kiae200
Pfeffer, T., Schürfeld, R., Colbatzky, F., Kracke, T., Kirschner, P., Medert, R., Freichel, M., Schumacher, D., Bartosova, M., Zarogiannis, S. G., Muckenthaler, M., Altamura, S., Krug, S. M., Pezer, S., Volk, N., Schwab, C., Duensing, S., Fleming, T., Heidenreich, E., Poschet, E., Hell, R., Schmitt. C. P., Peters. V. (2024) Knock-out of dipeptidase CN2 in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para- and transcellular solute transport. Acta Physiologica 240(4):e14126. doi: 10.1111/apha.14126
Gong, X., Boyer, J.B., Gierlich, S., Pożoga, M., Weidenhausen, J., Sinning, I., Meinnel, T., Giglione, C., Wang, Y., Hell, R., Wirtz, M. (2024) HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana. Cell Reports 43: 113768, https://doi.org/10.1016/j.celrep.2024.113768
Pfaff, D. H., Poschet, G., Hell, R., Szendrödi, J., Teleman, A. A. (2023) Walking 200 min per day keeps the bariatric surgeon away. Heliyon 9: e16556. https://doi.org/10.1016/j.heliyon.2023.e16556
Coppa, E., Vigani, G., Aref, R., Savatin, D., Bigini, V., Hell, R., Astolfi, S., (2023) Differential modulation of Target of Rapamycin (TOR) activity under single and combined iron and sulfur deficiency in tomato plants. Plant J. 115: 127–138. doi: 10.1111/tpj.16213
Wirtz, M., Leehuis, W., Hell, R. (2023) Dynamic association of the plastid localized cysteine synthase complex is vital for efficient cysteine production, photosynthesis, and grana thylakoid formation in transgenic tobacco. J. Exp. Bot. 74:3379-3394. doi: 10.1093/jxb/erad099.
Gegner, H.M., Naake, T., Dugourd, A., Müller, T., Czernilofsky, F., Kliewer, G., Jäger, E., Helm, B., Kunze-Rohrbach, N., Klingmüller, U., Hopf, C., Müller-Tidow, C., Dietrich, S., Saez-Rodriguez, J., Huber, W., Hell, R., Poschet, G., Krijgsveld, J. (2022) Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis. Front. Mol. Biosci. 9:961448, https://doi.org/10.3389/fmolb.2022.961448
Khan, M.S., Soyk, A., Wolf, I., Peter, M., Meyer, A.J., Rausch, T., Wirtz, M., Hell, R. (2022) Discriminative long-distance transport of selenate and selenite triggers glutathione oxidation in specific subcellular compartments of root and shoot cells in Arabidopsis. Front. Plant Sci. 13: doi:10.3389/fpls.2022.894479
Dong, Y., Aref, R., Forieri, I., Schiel, D., Leemhuis, W., Meyer, C., Hell, R.1, Wirtz, M. (2022) The plant TOR kinase tunes autophagy and meristem activity for nutrient stress-induced developmental plasticity. Plant Cell 34: 3814-3829. doi: 10.1093/plcell/koac201.
Miklánková, P., Linster, E., Boyer, J.-B., Weidenhausen, J., Mueller, J., Armbruster, L., Lapouge, K., De La Torre, C., Bienvenut, W., Sticht, C., Mann, M., Meinnel, T., Sinning, I., Giglione, C., Hell, R., Wirtz, M. (2022) HYPK promotes the activity of the N-acetyltransferase A complex to determine proteostasis of nonAc-X/N-degron containing proteins. Science Advances 8 (24):eabn6153. doi: 10.1126/sciadv.abn6153
Gegner, H. M., Mechtel, N., Heidenreich, E., Wirth, A., Garcia Cortizo, F., Bennewitz, K., Fleming, T. H., Andresen, C., Freichel, M., Teleman, A. A., Kroll, J., Hell, R., Poschet, G. (2022) Deep metabolic profiling assessment of tissue extraction protocols for three model organisms. Front. Chem. 10: 869732. doi: 10.3389/fchem.2022.869732
Linster E, Forero Ruiz FL, Miklánkova P, Ruppert T, Mueller J, Armbruster L, Gong X, Serino G, Mann M, Hell R, Wirtz M. (2022) Cotranslational N-degron masking by acetylation promotes proteome stability in plants. Nat Commun. 13(1): 810. doi: 10.1038/s41467-022-28414-5.
Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J. Fleming, T., Sticht, C., Hausser, I., Hell. R., Hammes, H.-P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology, 50: 102249, doi: 10.1016/j.redox.2022.102249
Huber, M., Armbruster, L., Etherington, R. D., De La Torre, C., Hawkesford, M. J., Sticht, C., Gibbs, D. G., Hell, R., Wirtz, M. (2022) Disruption of the Nα-acetyltransferase NatB causes sensitivity to reductive stress. Front. Plant Sci. 12:799954, doi.org/10.3389/fpls.2021.799954