Developmental Biology/PhysiologyDr. Thomas Thumberger

??/?? T cell lineage outcome is regulated by intrathymic cell localization and environmental signals

Aghaallaei N, Dick AM, Tsingos E, Inoue D, Hasel E, Thumberger T, Toyoda A, Leptin M, Wittbrodt J, Bajoghli B.

Sci Adv

2021

Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

Zilova L, Weinhardt V, Tavhelidse T, Schlagheck C, Thumberger T, Wittbrodt J.

Elife

2021

A patient-based medaka alg2 mutant as a model for hypo-N-glycosylation

Gücüm S, Sakson R, Hoffmann M, Grote V, Becker C, Pakari K, Beedgen L, Thiel C, Rapp E, Ruppert T, Thumberger T, Wittbrodt J.

Development

2021

The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development

Cirksena K, Hütte HJ, Shcherbakova A, Thumberger T, Sakson R, Weiss S, Jensen LR, Friedrich A, Todt D, Kuss AW, Ruppert T, Wittbrodt J, Bakker H, Buettner FFR.

Mol Cell Proteomics

2021

A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease

Mederer T, Schmitteckert S, Volz J, Martínez C, Röth R, Thumberger T, Eckstein V, Scheuerer J, Thöni C, Lasitschka F, Carstensen L, Günther P, Holland-Cunz S, Hofstra R, Brosens E, Rosenfeld JA, Schaaf CP, Schriemer D, Ceccherini I, Rusmini M, Tilghman J, Luzón-Toro B, Torroglosa A, Borrego S, Sze-Man Tang C, Garcia-Barceló M, Tam P, Paramasivam N, Bewerunge-Hudler M, De La Torre C, Gretz N, Rappold GA, Romero P, Niesler B.

PLoS Genet

2020

Genetic and functional insights into the fractal structure of the heart

Meyer HV, Dawes TJW, Serrani M, Bai W, Tokarczuk P, Cai J, de Marvao A, Henry A, Lumbers RT, Gierten J, Thumberger T, Wittbrodt J, Ware JS, Rueckert D, Matthews PM, Prasad SK, Costantino ML, Cook SA, Birney E, O'Regan DP.

Nature

2020

Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish

Bosze B, Ono Y, Mattes B, Sinner C, Gourain V, Thumberger T, Tlili S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S.

Histochem Cell Biol

2020

Swift Large-scale Examination of Directed Genome Editing

Hammouda OT, Böttger F, Wittbrodt J, Thumberger T.

PLoS One

2019

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus

Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M.

iScience

2018

Efficient single-copy HDR by 5' modified long dsDNA donors

Gutierrez-Triana JA, Tavhelidse T, Thumberger T, Thomas I, Wittbrodt B, Kellner T, Anlas K, Tsingos E, Wittbrodt J.

Elife

2018

Correction: Dynamics of in vivo ASC speck formation

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M.

J Cell Biol

2017

Dynamics of in vivo ASC speck formation

Kuri P, Schieber NL, Thumberger T, Wittbrodt J, Schwab Y, Leptin M.

J Cell Biol

2017

Correction: CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL.

PLoS One

2017

Bifacial stem cell niches in fish and plants

Shi D, Tavhelidse T, Thumberger T, Wittbrodt J, Greb T.

Curr Opin Genet Dev

2017

A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse

Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, Campione M, Deißler K, Lewandoski M, Thumberger T, Schweickert A, Fainsod A, Steinbeißer H, Blum M.

Sci Rep

2017

Leftward Flow Determines Laterality in Conjoined Twins

Tisler M, Thumberger T, Schneider I, Schweickert A, Blum M.

Curr Biol

2017

Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses

Inoue D, Stemmer M, Thumberger T, Ruppert T, Bärenz F, Wittbrodt J, Gruss OJ.

Nat Commun

2017

Cilia are required for asymmetric nodal induction in the sea urchin embryo

Tisler M, Wetzel F, Mantino S, Kremnyov S, Thumberger T, Schweickert A, Blum M, Vick P.

BMC Dev Biol

2016

An eye on light-sheet microscopy

Kromm D, Thumberger T, Wittbrodt J.

Methods Cell Biol

2016

Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish

Bert B, Chmielewska J, Bergmann S, Busch M, Driever W, Finger-Baier K, Hößler J, Köhler A, Leich N, Misgeld T, Nöldner T, Reiher A, Schartl M, Seebach-Sproedt A, Thumberger T, Schönfelder G, Grune B.

EMBO J

2016

Noninvasive In Toto Imaging of the Thymus Reveals Heterogeneous Migratory Behavior of Developing T Cells

Bajoghli B, Kuri P, Inoue D, Aghaallaei N, Hanelt M, Thumberger T, Rauzi M, Wittbrodt J, Leptin M.

J Immunol

2015

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL.

PLoS One

2015

The evolution and conservation of left-right patterning mechanisms

Blum M, Feistel K, Thumberger T, Schweickert A.

Development

2014

A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles

Walentek P, Bogusch S, Thumberger T, Vick P, Dubaissi E, Beyer T, Blum M, Schweickert A.

Development

2014

Ciliogenesis and cerebrospinal fluid flow in the developing Xenopus brain are regulated by foxj1

Hagenlocher C, Walentek P, M Ller C, Thumberger T, Feistel K.

Cilia

2013

Ciliary and non-ciliary expression and function of PACRG during vertebrate development

Thumberger T, Hagenlocher C, Tisler M, Beyer T, Tietze N, Schweickert A, Feistel K, Blum M.

Cilia

2012

Quantitative analysis of embryogenesis: a perspective for light sheet microscopy

Höckendorf B, Thumberger T, Wittbrodt J.

Dev Cell

2012

Connexin26-mediated transfer of laterality cues in Xenopus

Beyer T, Thumberger T, Schweickert A, Blum M.

Biol Open

2012

ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development

Walentek P, Beyer T, Thumberger T, Schweickert A, Blum M.

Cell Rep

2012

Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus

Beyer T, Danilchik M, Thumberger T, Vick P, Tisler M, Schneider I, Bogusch S, Andre P, Ulmer B, Walentek P, Niesler B, Blum M, Schweickert A.

Curr Biol

2012

Linking early determinants and cilia-driven leftward flow in left-right axis specification of Xenopus laevis: a theoretical approach

Schweickert A, Walentek P, Thumberger T, Danilchik M.

Differentiation

2012

The nodal inhibitor Coco is a critical target of leftward flow in Xenopus

Schweickert A, Vick P, Getwan M, Weber T, Schneider I, Eberhardt M, Beyer T, Pachur A, Blum M.

Curr Biol

2010

Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow

Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB.

Development

2009

Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis

Vick P, Schweickert A, Weber T, Eberhardt M, Mencl S, Shcherbakov D, Beyer T, Blum M.

Dev Biol

2009

Xenopus, an ideal model system to study vertebrate left-right asymmetry

Blum M, Beyer T, Weber T, Vick P, Andre P, Bitzer E, Schweickert A.

Dev Dyn

2009

Evolution of leftward flow

Blum M, Weber T, Beyer T, Vick P.

Semin Cell Dev Biol

2009

Cilia-driven leftward flow determines laterality in Xenopus

Schweickert A, Weber T, Beyer T, Vick P, Bogusch S, Feistel K, Blum M.

Curr Biol

2007