AG HolsteinVeröffentlichungen

Holstein TW, Watanabe H, Ozbek S. (1. Curr Top Dev Biol. 2011;97:137-77.). Signaling pathways and axis formation in the lower metazoa. 1. Curr Top Dev Biol. 2011;97:137-77.

Nakamura Y, Tsiairis CD, Özbek S, Holstein TW. (2011). Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer. Proc Natl Acad Sci U S A.108(22):9137-42.

Hwang JS, Takaku Y, Momose T, Adamczyk P, Özbek S, Ikeo K, Khalturin K, Hemmrich G, Bosch TC, Holstein TW, David CN, Gojobori T. (2010). Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra. Proc Natl Acad Sci U S A.107(43):18539-44.

Holstein TW, Hess MW, Salvenmoser W. ( 4. Methods Cell Biol. 2010;96:285-306. ). Preparation techniques for transmission electron microscopy of Hydra. 4. Methods Cell Biol. 2010;96:285-306. Pubmed

Gurley KA, Elliott SA, Simakov O, Schmidt HA, Holstein TW, Sánchez Alvarado A. (2010). Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol.347(1):24-39. Pubmed

Adamczyk P, Zenkert C, Balasubramanian PG, Yamada S, Murakoshi S, Sugahara K, Hwang JS, Gojobori T, Holstein TW, Ozbek S. (2010). A non-sulfated chondroitin stabilizes membrane tubulation in cnidarian organelles. J Biol Chem.285(33):25613-23.

Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam D, Disbennett K, Pfannkoch C, Sumin N, Sutton GG, Viswanathan LD, Walenz B, Goodstein DM, Hellsten U, Kawashima T, Prochnik SE, Putnam NH, Shu S, Blumberg B, Dana CE, Gee L, Kibler DF, Law L, Lindgens D, Martinez DE, Peng J, Wigge PA, Bertulat B, Guder C, Nakamura Y, Ozbek S, Watanabe H, Khalturin K, Hemmrich G, Franke A, Augustin R, Fraune S, Hayakawa E, Hayakawa S, Hirose M, Hwang JS, Ikeo K, Nishimiya-Fujisawa C, Ogura A, Takahashi T, Steinmetz PR, Zhang X, Aufschnaiter R, Eder MK, Gorny AK, Salvenmoser W, Heimberg AM, Wheeler BM, Peterson KJ, Böttger A, Tischler P, Wolf A, Gojobori T, Remington KA, Strausberg RL, Venter JC, Technau U, Hobmayer B, Bosch TC, Holstein TW, Fujisawa T, Bode HR, David CN, Rokhsar DS, Steele RE. (2010). The dynamic genome of Hydra. Nature.464(7288):592-6.

Dürrnagel S, Kuhn A, Tsiairis CD, Williamson M, Kalbacher H, Grimmelikhuijzen CJ, Holstein TW, Gründer S. (2010). Three homologous subunits form a high affinity peptide-gated ion channel in Hydra. J Biol Chem.285(16):11958-65.

Watanabe H, Hoang VT, Mättner R, Holstein TW. (2009). Immortality and the base of multicellular life: Lessons from cnidarian stem cells. Semin Cell Dev Biol.20(9):1114-25.

Watanabe H, Fujisawa T, Holstein TW. (2009). Cnidarians and the evolutionary origin of the nervous system. Dev Growth Differ.51(3):167-83.

Ozbek S, Balasubramanian PG, Holstein TW. (2009). Cnidocyst structure and the biomechanics of discharge. Toxicon.54(8):1038-45.

Philipp I, Aufschnaiter R, Ozbek S, Pontasch S, Jenewein M, Watanabe H, Rentzsch F, Holstein TW, Hobmayer B. (2009). Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra. Proc Natl Acad Sci U S A.106(11):4290-5.

Lengfeld T, Watanabe H, Simakov O, Lindgens D, Gee L, Law L, Schmidt HA, Ozbek S, Bode H, Holstein TW. (2009). Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev Biol.330(1):186-99.

Wheeler BM, Heimberg AM, Moy VN, Sperling EA, Holstein TW, Heber S, Peterson KJ. (2009). The deep evolution of metazoan microRNAs. Evol Dev.11(1):50-68.

Bode H, Lengfeld T, Hobmayer B, Holstein TW. ( 15. Methods Mol Biol. 2008;469:69-84. ). Detection of expression patterns in Hydra pattern formation. 15. Methods Mol Biol. 2008;469:69-84.

Holstein TW. ( 16. Methods Mol Biol. 2008;469:47-54. ). Wnt signaling in cnidarians. 16. Methods Mol Biol. 2008;469:47-54.

David CN, Ozbek S, Adamczyk P, Meier S, Pauly B, Chapman J, Hwang JS, Gojobori T, Holstein TW. (2008). Evolution of complex structures: minicollagens shape the cnidarian nematocyst. Trends Genet.24(9):431-8.

Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bächinger HP, Holstein TW, Ozbek S. (2007). Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts. J Mol Biol.376(4):1008-20.

Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein TW, Grimmelikhuijzen CJ, Gründer S. (2007). A peptide-gated ion channel from the freshwater polyp Hydra. J Biol Chem.282(48):35098-103.

Meier S, Jensen PR, Adamczyk P, Bächinger HP, Holstein TW, Engel J, Ozbek S, Grzesiek S. (2007). Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall. J Mol Biol.368(3):718-28.

Rentzsch F, Guder C, Vocke D, Hobmayer B, Holstein TW. (2007). An ancient chordin-like gene in organizer formation of Hydra. Proc Natl Acad Sci U S A.104(9):3249-54.

Meier S, Jensen PR, David CN, Chapman J, Holstein TW, Grzesiek S, Ozbek S. (2007). Continuous molecular evolution of protein-domain structures by single amino acid changes. Curr Biol.17(2):173-8. Pubmed

Guder C, Philipp I, Lengfeld T, Watanabe H, Hobmayer B, Holstein TW. (2006). The Wnt code: cnidarians signal the way. Oncogene.25(57):7450-60.

Rentzsch F, Anton R, Saina M, Hammerschmidt M, Holstein TW, Technau U. (2006). Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning. Dev Biol.296(2):375-87.

Hellstern S, Stetefeld J, Fauser C, Lustig A, Engel J, Holstein TW, Ozbek S. (2006). Structure/function analysis of spinalin, a spine protein of Hydra nematocysts. FEBS J.273(14):3230-7.

Nüchter T, Benoit M, Engel U, Ozbek S, Holstein TW. (2006). Nanosecond-scale kinetics of nematocyst discharge. Curr Biol.16(9):R316-8.

Guder C, Pinho S, Nacak TG, Schmidt HA, Hobmayer B, Niehrs C, Holstein TW. (2006). An ancient Wnt-Dickkopf antagonism in Hydra. Development.133(5):901-11.

Technau U, Rudd S, Maxwell P, Gordon PM, Saina M, Grasso LC, Hayward DC, Sensen CW, Saint R, Holstein TW, Ball EE, Miller DJ. (2005). Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians. Trends Genet.21(12):633-9.

Philipp I, Holstein TW, Hobmayer B. (2005). HvJNK, a Hydra member of the c-Jun NH2-terminal kinase gene family, is expressed during nematocyte differentiation. Gene Expr Patterns.5(3):397-402.

Kusserow A, Pang K, Sturm C, Hrouda M, Lentfer J, Schmidt HA, Technau U, von Haeseler A, Hobmayer B, Martindale MQ, Holstein TW. (2005). Unexpected complexity of the Wnt gene family in a sea anemone. Nature.433(7022):156-60.

Rentzsch F, Hobmayer B, Holstein TW. (2005). Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis. Dev Biol.278(1):1-12.

Ozbek S, Pokidysheva E, Schwager M, Schulthess T, Tariq N, Barth D, Milbradt AG, Moroder L, Engel J, Holstein TW. (2004). The glycoprotein NOWA and minicollagens are part of a disulfide-linked polymer that forms the cnidarian nematocyst wall. J Biol Chem.279(50):52016-23.

Pokidysheva E, Milbradt AG, Meier S, Renner C, Häussinger D, Bächinger HP, Moroder L, Grzesiek S, Holstein TW, Ozbek S, Engel J. (2004). The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall. J Biol Chem.279(29):30395-401.

Lindgens D, Holstein TW, Technau U. (2004). Hyzic, the Hydra homolog of the zic/odd-paired gene, is involved in the early specification of the sensory nematocytes. Development.131(1):191-201.

Holstein TW, Hobmayer E, Technau U. (2003). Cnidarians: an evolutionarily conserved model system for regeneration? Dev Dyn.226(2):257-67.

Engel U, Ozbek S, Streitwolf-Engel R, Petri B, Lottspeich F, Holstein TW. (2002). Nowa, a novel protein with minicollagen Cys-rich domains, is involved in nematocyst formation in Hydra. J Cell Sci.115(Pt 20):3923-34. Pubmed

Hobmayer B, Rentzsch F, Holstein TW. (2001). Identification and expression of HySmad1, a member of the R-Smad family of TGFbeta signal transducers, in the diploblastic metazoan Hydra. Dev Genes Evol.211(12):597-602.

Engel U, Pertz O, Fauser C, Engel J, David CN, Holstein TW. (2001). A switch in disulfide linkage during minicollagen assembly in Hydra nematocysts. EMBO J.20(12):3063-73.

Hobmayer B, Snyder P, Alt D, Happel CM, Holstein TW. (2001). Quantitative analysis of epithelial cell aggregation in the simple metazoan Hydra reveals a switch from homotypic to heterotypic cell interactions. Cell Tissue Res.304(1):147-57.